Capturing eukaryotic transporters in action
Lead Research Organisation:
Imperial College London
Department Name: Life Sciences
Abstract
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Publications
Cioccolo S
(2024)
The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs.
in RSC chemical biology
Woubshete M
(2024)
Advances in Membrane Mimetic Systems for Manipulation and Analysis of Membrane Proteins: Detergents, Polymers, Lipids and Scaffolds.
in ChemPlusChem
Woubshete M
(2024)
The dimer of human SVCT1 is key for transport function.
in Biochimica et biophysica acta. Biomembranes
| Description | Our data indicates that UapA, an integral membrane protein transporter adopts distinct conformational states as part of its function. We are currently working on the manuscript describing these findings. |
| Exploitation Route | Greater insight into the mechanism of action of transporters is likely to result in greater understanding of how these can be effectively used as drug targets. |
| Sectors | Education |
| Title | Dataset for Cioccolo et al, DOI: 10.1039/d4cb00110a |
| Description | All the background data for the published manuscript |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | None so far |
| URL | https://doi.org/10.6084/m9.figshare.26268325.v1 |
| Description | Collaboration with University of Manchester |
| Organisation | University of Manchester |
| Department | School of Biological Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are producing protein in a range of diffent conformational states for analysis by HDX-MS by our collaborators at University of Manchester |
| Collaborator Contribution | The Manchester group are carrying out the HDX-MS analysis |
| Impact | None as yet |
| Start Year | 2018 |