Canada Partnering Award: Revealing the biological and molecular functions of organelle contacts in mammalian cells
Lead Research Organisation:
University of Exeter
Department Name: Biosciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Carmichael R
(2023)
Organelle Membrane Extensions in Mammalian Cells
in Biology
Kors S
(2022)
VAP Proteins - From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal Disease.
in Frontiers in cell and developmental biology
Kors S
(2022)
Controlling contacts-Molecular mechanisms to regulate organelle membrane tethering.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Kors S
(2022)
Multiple Ways to Keep FFAT Under Control!
in Contact (Thousand Oaks (Ventura County, Calif.))
| Description | IB syllabus |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Description | Understanding the molecular mechanisms of organelle communication in the regulation of cellular lipid metabolism and developmental processes |
| Amount | £638,000 (GBP) |
| Funding ID | BB/W015420/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2022 |
| End | 09/2025 |
| Description | Organelle contacts and oxidative stress |
| Organisation | University of Leuven |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Analysis of the impact of oxidative stress on membrane contacts sites/organelle cooperation in human cells using molecular cell biology and ultrastructural studies/quantitative EM. |
| Collaborator Contribution | The partner generated samples using a sophisticated cell model generated by the partner, which allows generation of H202/oxidative stress in different cellular compartments. |
| Impact | The collaboration generated data for publication and upcoming grant proposals. It contributed to skills training and closer cooperation with the partner. This is a multi-disciplinary cooperation which combines biochemical and cell biological/ultrastructural approaches. |
| Start Year | 2021 |
| Description | Biosciences Research Conference 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Our research team participated in the Biosciences Research Conference (28-29 June 20220 at the University. The conference brought together the diverse and dynamic research that is done in the Biosciences department. BBSRC-funded researchers were selected for an oral presentation and talked about the ongoing research in our lab or presented posters. A BBSRC-funded PDRA from our team was also a member of the organising committee. This sparked questions and discussions afterwards, informed others about our BBSRC-funded research and resulted in requests for more information or collaboration. It supported networking activities and contributed to the skills training of the BBSRC-funded team members (e.g., organisation, oral and poster presentation, communication). |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press Release - regulation of organelle contact |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release to inform and increase awareness of new discoveries in molecular cell biology with link to biomedicine/human disease with respect to the regulation of organelle contacts and organelle cooperation. Our study has shed new light on how organelle contacts are regulated at the molecular level. It sparked questions and discussions, increased awareness and interest. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.exeter.ac.uk/research/news/articles/newdiscoveryonregulationo.html |
| Description | Zellweger Charity Event 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | A member of the Zellweger UK charity and parent/carer of a Zellweger patient informed UG/PG students and academic staff about the work and aims of the ZUK charity and the day-to-day life with a Zellweger patient. This patient-centred online session complemented learning activities on the underlying biological science and diagnostics. The session was very well received and sparked questions and discussions afterwards. It greatly increased awareness of organelle/peroxisome-based disorders and our BBSRC funded research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.zellweger.org.uk/ |