Using fish biodiversity to understand brain evolution
Lead Research Organisation:
King's College London
Department Name: Developmental Neurobiology
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Taylor R
(2024)
Optimized Primary Culture of Neuronal Populations for Subcellular Omics Applications.
in Methods in molecular biology (Clifton, N.J.)
| Description | Our interaction with the Currie Lab in Melbourne led to insights into the early stage of forebrain development and finding unexpected commonalities between shark and higher vertebrates (birds and mammals) in the process of forebrain neural plate closure and progenitor organisation. Key experiments will be done in September 2023 to complete the study. |
| Exploitation Route | Publication will come out of this collaboration as well as further funding application as sharks provide unprecedented source of information on the essential mechanisms of forebrain evolution and the collaboration of CH and PC labs is a unique engine to provide insights into these mechanisms. |
| Sectors | Education,Environment,Healthcare |
| Description | Human Dev. Neuro Collabortive Satellite |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | CH led an initiative to develop a collaborative research programme to understand the human property of early CNS development. This collaboration is embedded inside the partnership space of the FCI. The research programme is co-led by James Briscoe, Kate Storey and Francois Guillemot. The ambition proposed by CH is to form an internationally visible hub focused in early stages of human brain and spinal cord development. |
| Collaborator Contribution | Our partners at the FCI provide expertise and supervision time as well as equipment to articulate our collaborative objectives. |
| Impact | We have developed a new research direction in early human forebrain development and from the expertise acquired we have now two publications in prep and been asked to join the Wellcome trust funded HDBI (see further collab. and further funding) and got funding for two postdoctoral posts to further develop this direction of research. |
| Start Year | 2018 |
| Description | Linking cell behaviour to progenitor fate in the human embryonic telencephalon |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide our expertise in vertebrate telencephalon early development, intellectual input to the whole network and our long experience in training technicians and postdoctoral fellows. The collaboration includes training of two postdoctoral fellows. We give access to our human cell culture equipment and use of our scRNAseq facility. Our long-standing experience in the field of telencephalon early development from fish to mammals provide a unique evolutionary perspective to the work. |
| Collaborator Contribution | Our partners provide the human tissue (HDBR) without which such ambitious project could not be done and the HDBI provides the unique ability to put our findings in the perspective of human development as a whole. |
| Impact | Just starting. |
| Start Year | 2022 |
| Description | Linking cell behaviour to progenitor fate in the human embryonic telencephalon |
| Organisation | University College London |
| Department | MRC/Wellcome Trust Human Developmental Biology Resource |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We provide our expertise in vertebrate telencephalon early development, intellectual input to the whole network and our long experience in training technicians and postdoctoral fellows. The collaboration includes training of two postdoctoral fellows. We give access to our human cell culture equipment and use of our scRNAseq facility. Our long-standing experience in the field of telencephalon early development from fish to mammals provide a unique evolutionary perspective to the work. |
| Collaborator Contribution | Our partners provide the human tissue (HDBR) without which such ambitious project could not be done and the HDBI provides the unique ability to put our findings in the perspective of human development as a whole. |
| Impact | Just starting. |
| Start Year | 2022 |
| Description | Dev Neuro Academy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Organisation of a couple of weeks of interaction and research activities with school pupils under-represented at university level (schools having very few kids going to university). We make them familiar with university research and education and build their confidence in considering university education as attainable and interesting for them. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2022 |
| URL | https://devneuro.org/cdn/public-engagement-dna.php |