Ageing Research Translation (ART) of Healthy Ageing Network

Lead Research Organisation: Newcastle University
Department Name: Translational and Clinical Res Institute

Abstract

The global population is ageing - more people are living longer lives and a greater proportion of the population are aged 65 and over than at any time in the past. This is clearly good news, however improvements in healthspan (that is, the number of years people spend in good health, living independently) have not kept pace with improvements in lifespan (the number of years people live for). This means that the additional years of life are not always lived in good health.

To address this, the UK government has set the ambitious target of ensuring that people can enjoy at least five additional healthy, independent years of life by 2035. However, a recent House of Lords Science and Technology Committee report on healthy ageing has concluded that this target is unlikely to be met unless we develop new ways to research ageing that lead to the identification of effective methods to promote healthy ageing across life. In particular, the House of Lords committee noted the need to join up different areas of ageing research to make sure that discoveries in the laboratory are followed up by studies in people.

The aim of the Ageing Research Translation (ART) of Healthy Ageing Network is to address this scientific challenge. Our Network will create links between laboratory research, detailed studies in humans, and existing sets of information on health, illness and lifestyle. We will combine these areas of expertise to build a unique Translational Platform (a series of studies with standardised protocols, shared recruitment methods and shared outcome measures) for Healthy Ageing across the Life Course to test ways to improve people's health and wellbeing from birth to old age. To achieve this vision, the Network will bring together researchers from different academic disciplines across the UK and beyond, including people with expertise in the biology of ageing, epidemiology, patient care, physiology, clinical research studies including trials, mathematics, statistics and data science along with members of the public and representatives from charities, policymakers and industry.

Through their involvement in the Network and the wide range of activities organised, members will be supported to work together to find new ways to study underlying biological processes of ageing in humans and, to use the evidence generated from this research to develop and test interventions that promote healthy ageing. We will hold a series of stakeholder meetings and conferences to bring people together to form new links and share knowledge. Importantly, we will nurture the careers of new researchers. The ART of Healthy Ageing Network will provide the training and opportunities that they need to build successful careers in translational ageing research and work successfully with a broad range of colleagues. Finally, the ART of Healthy Ageing Network will promote opportunities for closer working through a series of pilot projects, enabling different groups of researchers to start solving problems and overcoming technical, ethical and organisational barriers to make sure that we can build this UK-wide platform to conduct ageing studies in humans.

The activities of the ART of Healthy Ageing Network will deliver a growing interdisciplinary network of researchers, a thriving community of early career researchers with interdisciplinary training, a broad and engaged stakeholder community, a clear road map for growing the Network and developing UK infrastructure, and projects showing initial proof-of-concept for our Translational Platform for Healthy Ageing across the Life Course. It will generate new collaborations between researchers with the critical mass necessary to develop credible applications for further funding. By delivering additional funding and hence capacity to do more research, our ART of Healthy Ageing Network will accelerate translational Ageing research in the UK and internationally to deliver the goal of improving healthspan for all.

Technical Summary

The UK government has set the ambitious target of ensuring that people can enjoy at least five additional healthy, independent years of life by 2035 and that the gap between the experience of the richest and poorest is reduced. A recent House of Lords Science and Technology Committee report on healthy ageing makes it clear that these targets will not be met with current approaches to research, policy and service delivery. The scientific challenge is to identify novel approaches to research on ageing across the life course with clear pathways to translation.

The ART of Healthy Ageing Network will meet this challenge by catalysing ever-closer working relationships across three key areas of research activity: a) large population-based and routine data cohorts, b) deep-phenotyped life course ageing cohorts with human tissue samples, and c) centres of excellence in the biology of ageing. The Network will bring together a broad range of academic disciplines and stakeholders representing the public, policy and industry. It will build the capacity, knowledge and resources needed to drive forward discovery science in human biological ageing, and a Translational Platform for Healthy Ageing across the Life Course to test interventions to improve healthspan.

The activities of the ART of Healthy Ageing Network will deliver a growing interdisciplinary network of researchers, a thriving community of early career researchers with interdisciplinary training, a broad and engaged stakeholder community, a clear road map for growing the Network and developing UK infrastructure, and initial proof-of-concept for our Translational Platform for Healthy Ageing across the Life Course. It will generate new collaborations with the critical mass to develop credible bids for future funding calls. These synergies will deliver additional funding and hence capacity to accelerate translational Ageing research in the UK and internationally with the ultimate goal of improving healthspan for all.

Publications

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Bellfield RAA (2022) The Athlete's Heart and Machine Learning: A Review of Current Implementations and Gaps for Future Research. in Journal of cardiovascular development and disease

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Vinciguerra M (2022) New use for an old drug: Metformin and atrial fibrillation. in Cell reports. Medicine

 
Description The purpose of this funding award is to develop the ART of Healthy Ageing Network. The objectives of this Network are to:
1) Deliver a growing interdisciplinary network of researchers with a focus on addressing novel questions on underlying biological processes of ageing that are tractable and translating these into trials of interventions in humans
2) Grow a thriving community of early career researchers (ECR) with access to interdisciplinary training opportunities across multiple research organisations
3) Support a broad and engaged stakeholder community who are actively involved in both shaping the research agenda and in knowledge transfer
4) Produce a clear road map and initial proof-of-concept for a Translational Platform for Healthy Ageing across the Life Course integrating UK infrastructure for studying human ageing biology and testing interventions
In year 1 we have focused on the first two of these objectives.
Key achievements include building an engaged network of over 140 members from ~40 institutions with wide geographical coverage, representing multiple disciplines and all career stages.
Work to build our Network has been facilitated by the recruitment of a Network Manager with extensive experience who has helped to develop and deliver a clear communications plan focused on raising the Network's profile and engaging new Network members. We have also attracted Network members by publicising it widely via conference presentations, launch events, Twitter, our website and a Nature Aging correspondence piece.
Through our work to build the Network, we have achieved the aim of growing a thriving community of early career researchers; a total of 71 early career researchers are Network members and have indicated that they are keen to pursue interdisciplinary research on ageing with a translational focus.
The Network Management Group's ECR leads have worked closely with this ECR community to establish their met and unmet development needs. An online survey had 69 responses and findings from this survey and follow-up focus groups have allowed us to set priorities for future events and training opportunities that we will deliver to support our ECR community in the second year of the grant.
To help establish the building blocks for a translational platform for healthy ageing, we have overseen an open competition for pump-priming funding. We were pleased to receive 10 high quality applications all of which demonstrated clear alignment with the overall objectives of the Network. We were able to make four awards within our funding envelope, three of which are led by ECR and all of which provided a clear demonstration of their commitment to interdisciplinary collaboration and research capacity development.
Alongside our work to build the Network we are also currently working to build connections with a range of relevant stakeholders and have already received endorsement from the British Geriatrics Society (clinical community) and the British Society for Research into Ageing (Biology of Ageing community).
Exploitation Route By joining our Network, contributing to our activities and applying for our pump-priming funding awards, Network members are benefiting from opportunities to develop new and existing interdisciplinary research collaborations focused on translational ageing research.
The ultimate focus of the ART of Healthy Ageing Network is to enable research teams to move seamlessly from discovery science to effective, efficient intervention testing to improve healthy lifespan. To achieve this, the Network needs to bring together a broad range of interdisciplinary researchers in an effective way, and provide them with the tools, resources and infrastructure needed to deliver translational ageing research.
We are already leveraging the range of expertise within our Network to develop a roadmap specifying how we will develop and deliver a translational research platform; such a platform needs to accommodate the needs of research at each point of the translational circle - from discovery science and epidemiology, through experimental medicine, clinical trials, and implementation into policy and practice. We will then use the expertise within our Network to develop the building blocks that this translational ageing research platform requires. We are scoping out what resources are already in place, developing curated lists of other resources and asking our Network members and broader stakeholders what resources and infrastructure would be most helpful to them in delivering translational research.
We plan to develop a series of further discrete pieces of work to develop other building blocks - a process that will rely heavily on bringing together different disciplines working together within our Network.
The overall impact of this work will be that more innovations are able to move from the laboratory or desktop, through to human testing, clinical trials, and implementation in policy and practice, with consequent improvements in healthy life expectancy.
Sectors Digital/Communication/Information Technologies (including Software),Education,Healthcare

URL https://research.ncl.ac.uk/artofhealthyageing
 
Description ART of Healthy Ageing Network Early Career Researcher online survey
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact One of the unmet needs identified by our work with the ECR community is additional support for researchers keen to work across disciplines in breaking down some of the barriers to interdisciplinary working; an in person ECR event is planned in 2023 which will include a session on how to learn each other's languages with a view to begin addressing this.
 
Description Putting health at the heart of a new Ageing Workforce Strategy
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
URL https://www.physoc.org/events/how-can-we-develop-a-national-ageing-workforce-strategy/
 
Description ART (Ageing Research Translation) of Healthy Ageing Network 
Organisation Liverpool John Moores University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network Management Group supported by the Network Manager are responsible for delivering a growing interdisciplinary network of researchers with a focus on addressing novel questions on underlying biological processes of ageing that are tractable and translating these into trials of interventions in humans.
Collaborator Contribution The Network Management Group comprises academics from multiple disciplines and career stages all of whom contribute knowledge and insights from their own complementary areas of expertise. All members of the Network Management Group contribute to monthly meetings and activities focused on achieving the objectives of the Network. Drawing on established links within the Network Management Group, we have received endorsement from the British Geriatrics Society (clinical community) and the British Society for Research into Ageing (Biology of Ageing community), with initial conference engagement events already held and more planned.
Impact In the first year, we have built a network of over 140 members from ~40 institutions with wide geographical coverage, representing multiple disciplines and all career stages. We have achieved excellent levels of engagement with our Network members including over 70 early career researchers who are keen to pursue interdisciplinary research on ageing with a translational focus. Excellent levels of engagement are highlighted by good levels of attendance at our events and the fact that 9 of the 10 pump-priming funding applications we received were led by ECR and all 10 applications provided a clear demonstration of their intent to contribute to research capacity development.
Start Year 2022
 
Description ART (Ageing Research Translation) of Healthy Ageing Network 
Organisation Manchester Metropolitan University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network Management Group supported by the Network Manager are responsible for delivering a growing interdisciplinary network of researchers with a focus on addressing novel questions on underlying biological processes of ageing that are tractable and translating these into trials of interventions in humans.
Collaborator Contribution The Network Management Group comprises academics from multiple disciplines and career stages all of whom contribute knowledge and insights from their own complementary areas of expertise. All members of the Network Management Group contribute to monthly meetings and activities focused on achieving the objectives of the Network. Drawing on established links within the Network Management Group, we have received endorsement from the British Geriatrics Society (clinical community) and the British Society for Research into Ageing (Biology of Ageing community), with initial conference engagement events already held and more planned.
Impact In the first year, we have built a network of over 140 members from ~40 institutions with wide geographical coverage, representing multiple disciplines and all career stages. We have achieved excellent levels of engagement with our Network members including over 70 early career researchers who are keen to pursue interdisciplinary research on ageing with a translational focus. Excellent levels of engagement are highlighted by good levels of attendance at our events and the fact that 9 of the 10 pump-priming funding applications we received were led by ECR and all 10 applications provided a clear demonstration of their intent to contribute to research capacity development.
Start Year 2022
 
Description ART (Ageing Research Translation) of Healthy Ageing Network 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network Management Group supported by the Network Manager are responsible for delivering a growing interdisciplinary network of researchers with a focus on addressing novel questions on underlying biological processes of ageing that are tractable and translating these into trials of interventions in humans.
Collaborator Contribution The Network Management Group comprises academics from multiple disciplines and career stages all of whom contribute knowledge and insights from their own complementary areas of expertise. All members of the Network Management Group contribute to monthly meetings and activities focused on achieving the objectives of the Network. Drawing on established links within the Network Management Group, we have received endorsement from the British Geriatrics Society (clinical community) and the British Society for Research into Ageing (Biology of Ageing community), with initial conference engagement events already held and more planned.
Impact In the first year, we have built a network of over 140 members from ~40 institutions with wide geographical coverage, representing multiple disciplines and all career stages. We have achieved excellent levels of engagement with our Network members including over 70 early career researchers who are keen to pursue interdisciplinary research on ageing with a translational focus. Excellent levels of engagement are highlighted by good levels of attendance at our events and the fact that 9 of the 10 pump-priming funding applications we received were led by ECR and all 10 applications provided a clear demonstration of their intent to contribute to research capacity development.
Start Year 2022
 
Description Developing an implementation framework for stair falls interventions 
Organisation Liverpool John Moores University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network are funding this project via a pump-priming award.
Collaborator Contribution Stair falls cause many serious injuries in older adults. Improving home stair safety is vital to support healthy ageing. The Research to Improve Stair Climbing Safety (RISCS) group at Liverpool John Moores University have been leading efforts to improve stair safety. RISCS have designed ways to reduce stair falls in our state-of-the-art laboratory, but we do not yet know how these can be put into practice in real homes. To be effective, potential interventions must be acceptable and adopted by end users and professional stakeholders. The aim of the project is to create a multi-stakeholder framework to guide the implementation of stair fall interventions in older people's homes. The project will engage with a holistic network of stakeholders - including end users (older adults), service providers, housing providers, policy makers and regulatory bodies - to establish their attitudes, priorities and barriers towards the implementation of stair fall interventions in home settings.
Impact Award made in Jan 2023 with expectation of delivery by the end of 2023.
Start Year 2023
 
Description Developing non-invasive methods to measure muscle force, relaxation time and mitochondrial dysfunction in sarcopenia 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network are funding this project via a pump-priming award.
Collaborator Contribution Sarcopenia is the accelerated loss of muscle mass and function due to ageing. It leads to falls and reduced quality of life. Sarcopenia is very common affecting up to 10% of people over the age of 50. It can be diagnosed by a simple and inexpensive grip force test. However, this doesn't tell us about the cause of sarcopenia. One possible cause for sarcopenia is a problem with the mitochondria. Most of the energy in cells comes from mitochondria which are highly specialised energy powerhouses. Muscles need a lot of energy and so if there are problems with the mitochondria this can lead to sarcopenia. We will measure grip strength plus muscle relaxation time and muscle oxygen levels to see if we can detect problems with the mitochondria. This project aims to develop a simple, non-invasive test that can be used to reliably diagnose and monitor sarcopenia and mitochondrial dysfunction.
Impact Award made in Jan 2023 with expectation of delivery by the end of 2023.
Start Year 2023
 
Description Investigating the social and environmental contexts of habitual walking ACTIVities in older adult DYADs: A feasibility study 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network are funding this project via a pump-priming award.
Collaborator Contribution Staying physically active in older age is beneficial for physical capabilities and brain health but most older people do not meet physical activity recommendations. This may be due to clinical factors such as ill health, frailty, mobility issues or memory problems, but could also be due to social or environmental factors. For example, an individual's partner may encourage them to participate in walking activity by joining them on walks outside, or an individual may not want to walk outside if they don't feel the local area is safe. This study aims to explore how feasible and acceptable it is to use digital technology to continuously assess physical activity in older adult couples, and to identify key social and environmental factors which influence physical activity through a range of questionnaires, digital technology (i.e. activity monitors, GPS) and an activity diary kept over one week.
Impact Award made in Jan 2023 with expectation of delivery by the end of 2023.
Start Year 2023
 
Description Proteome dynamics to inform healthy muscle ageing 
Organisation Liverpool John Moores University
Country United Kingdom 
Sector Academic/University 
PI Contribution The ART of Healthy Ageing Network are funding this project via a pump-priming award.
Collaborator Contribution Most people over the age of 70 experience a progressive decline in the size and strength of their muscles. Often, the losses in strength are more pronounced than the reduction in muscle size. We aim to examine whether a decline in the quality of muscle proteins could explain this difference. Proteins are the workhorses within muscle and each muscle contains thousands of different proteins, collectively known as the proteome. Proteins must be regularly renewed to maintain muscle quality, and new proteins are produced all the time to replace old/damaged proteins. This study will be the first of its kind and will measure the dynamic renewal of proteins in the muscle of younger and older adults. Our project provides a diverse range of training for early-career researchers and our findings could help develop new treatments for maintaining muscle function in older adults by focusing on improving muscle protein quality.
Impact Award made in Jan 2023 with expectation of delivery by the end of 2023.
Start Year 2023
 
Description The UK Ageing Network (UKANet) 
Organisation United Kingdom Research and Innovation
Country United Kingdom 
Sector Public 
PI Contribution We have actively engaged in meetings and communications overseen by UKANet and have taken the opportunity to highlight the work of other networks in our external engagement activities.
Collaborator Contribution The UK Ageing Network (UKANet) coordinates communications across the 11 interdisciplinary ageing research networks, that each bring together researchers and stakeholders from different disciplines to better understand the biological mechanisms of ageing and their impact on human health.
Impact The ART of Healthy Ageing Network is promoted on the UKANet website as listed above.
Start Year 2022
 
Description ART of Healthy Ageing Network Early Career Researcher focus groups 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact We convened two ECR focus groups which were attended by a total of 12 ECR. The primary aim of these focus groups was to explore in more depth the findings from an online ECR survey (completed by 69 ECR) and to work together to identify priorities for future Network events and activities that could helpfully address the unmet needs of our ECR community.
We are currently developing plans for specific ART of Healthy Ageing Network organised events to be delivered in 2023 which will include an in-person event that addresses some of the unmet development needs of our ECR community.
Year(s) Of Engagement Activity 2022
 
Description ART of Healthy Ageing Network External Advisory Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The work of the ART of Healthy Ageing Network is overseen by an External Advisory Group (EAG) who we meet with every six months. The EAG comprises eight individuals (which includes two UKRI representatives), who provide a broad range of relevant expertise and perspectives from different disciplines and sectors - they are leading academic, policy and industry figures in ageing from the UK, US and Europe.
Year(s) Of Engagement Activity 2022,2023
 
Description ART of Healthy Ageing Network Newsletter - October 2022 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This newsletter was created for our External Advisory Group, Network members and Twitter followers to showcase what we had achieved since establishment of the Network in March 2022 and the important role the Network is beginning to play in bringing together people, knowledge, resources and infrastructure with a focus on effective translation of ageing research for patient and public benefit.
Year(s) Of Engagement Activity 2022
URL https://research.ncl.ac.uk/artofhealthyageing/newsletter/
 
Description ART of Healthy Ageing Network regional launch events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In 2022, we hosted two Network launch events. Our Newcastle University Launch event was held online on 18/5/2022 and was attended by 44 people. Our North West launch event was held online on 14/7/22 and was attended by 50 people. Their primary aim was to provide attendees with an overview of the Network's aims and encourage engagement and interdisciplinary collaboration between researchers from different academic institutions. Alongside talks from Network Management Group members we invited speakers with expertise in the biology of ageing to provide summaries of their research, highlight its translational potential and outline their views on opportunities for collaborative working across disciplines. Both events ended by highlighting what the Network hopes to provide for its members and what we hope members will contribute to the Network to ensure a healthy 2-way dialogue.
Year(s) Of Engagement Activity 2022
 
Description Presentation at British Geriatric Society (BGS) in November 2022 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Miles Witham and Prof Rachel Cooper delivered a talk 'Introducing the ART of Healthy Ageing Network'.
We used this opportunity to raise awareness of the Network to a clinical academic audience who can help us ensure that ageing research meets their needs and the needs of older people now and in the future.
This engagement led to new mailing list sign ups and Twitter followers.
Year(s) Of Engagement Activity 2022
URL https://twitter.com/GeriSoc/status/1593211979183050752/photo/1
 
Description Presentation at European Geriatric Medicine Society (EuGMS) in September 2022 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Miles Witham presented 'Introducing the ART (Ageing Research Translation) of Healthy Ageing Network: an exciting new opportunity to catalyse translational ageing research'
Year(s) Of Engagement Activity 2022