Sphingolipid biosynthesis in man and microbes
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
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Organisations
People |
ORCID iD |
Dominic Campopiano (Principal Investigator) |
Publications
Lowther J
(2011)
Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.
in FEBS letters
Lowther J
(2012)
Structural, mechanistic and regulatory studies of serine palmitoyltransferase.
in Biochemical Society transactions
Wadsworth JM
(2013)
The chemical basis of serine palmitoyltransferase inhibition by myriocin.
in Journal of the American Chemical Society
Beattie AE
(2013)
The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.
in BioMed research international
Description | We used this travel grant to send scientists from my group to a collaborating lab in Bethesda USA - Prof. Teresa Dunn. We developed structural and functional studies of the enzyme target. We also used this grant to collaborate and publish with a leading Japanese group. |
Exploitation Route | We also used the funding to attend Deater Family meetings - a family affected by a rare neuropathic disease HSN1. |
Sectors | Pharmaceuticals and Medical Biotechnology |
Description | This was a travel grant that allowed me to visit my USA collaborators in Washington DC and attend the key scientific meetings in the sphingolipid field. |
First Year Of Impact | 2008 |
Sector | Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal |