Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Potgieter M
(2015)
The dormant blood microbiome in chronic, inflammatory diseases.
in FEMS microbiology reviews
Koperdanova M
(2015)
Interpreting raised serum ferritin levels.
in BMJ (Clinical research ed.)
Pretorius E
(2016)
Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide.
in Journal of the Royal Society, Interface
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Pretorius E
(2016)
A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease.
in Journal of Alzheimer's disease : JAD
Kenny LC
(2017)
Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.
in Frontiers in medicine
Esteve C
(2017)
Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model.
in Biochimica et biophysica acta. Proteins and proteomics
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |