📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

Stem cell biology - Ageing, Developmental Biology, Genetically Modified Animals, Stem Cells, The 3Rs

Lead Research Organisation: University of Edinburgh
Department Name: The Roslin Institute

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

We aim to study the fundamental principles which control animal cell growth and diffrentiation. The experimental ability to investigate in vitro the molecular events determining and controlling cellular division and differentiation is extremely powerful in the study of biological function. In this regard, stem cells provide a unique experimental resource to tease apart the molecular mechanism controlling how a cell survives. In addition, intervention strategies based on stem cells have the potential to contribute new treatments of disease. The objectives of the theme are: To characterise signalling cross-talk in stem cell growth and differentiation. To derive ES/iPS cells from non-permissive species. To investigate germ cell development in vitro and in vivo.

Planned Impact

unavailable

Publications

10 25 50
publication icon
Arends MJ (2016) Animal and cellular models of human disease. in The Journal of pathology

publication icon
Boesze Zsuzsanna (2008) Producing recombinant human milk proteins in the milk of livestock species in BIOACTIVE COMPONENTS OF MILK

publication icon
Breton A (2013) Derivation and characterization of induced pluripotent stem cells from equine fibroblasts. in Stem cells and development

publication icon
Bruce A (2013) Novel GM animal technologies and their governance. in Transgenic research

publication icon
Burkard C (2018) Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection. in Journal of virology

publication icon
Bösze Z (2008) Producing recombinant human milk proteins in the milk of livestock species. in Advances in experimental medicine and biology

publication icon
Capocefalo A (2009) p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication. in Journal of virological methods

publication icon
Carlson DF (2012) Efficient TALEN-mediated gene knockout in livestock. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Chang SP (2013) Relative transgene expression frequencies in homozygous versus hemizygous transgenic mice. in Transgenic research

publication icon
Fahrenkrug SC (2010) Precision genetics for complex objectives in animal agriculture. in Journal of animal science

 
Description General Scheme - Bruce Whitelaw - Editing RELA S531P
Amount £30,000 (GBP)
Organisation Genus plc 
Sector Private
Country United Kingdom
Start 03/2017 
End 12/2019