Tissue damage and repair - Animal Diseases, Genetically Modified Organisms, Regenerative Medicine, Underpinning Cancer Research, Stem Cells
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
We will study the molecular players involved in disease that are often the same as those required for normal growth and development but are inappropriately activated or mutated. In addition, we will exploit this knowledge to develop new and better disease intervention strategies for application in both animal and human health. The objectives of the theme are: To assess role of bone mineralisation and growth in relation to skeletal disease. To characterise novel mediators of vascular calcification. To characterise role of stem cells in tissue repair. To develop animal models of disease. To identify genes characteristic of mesenchymal cells and the factors which regulate them.
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Christopher Whitelaw (Principal Investigator) |
Publications
Arends MJ
(2016)
Animal and cellular models of human disease.
in The Journal of pathology
Boesze Zsuzsanna
(2008)
Producing recombinant human milk proteins in the milk of livestock species
in BIOACTIVE COMPONENTS OF MILK
Breton A
(2013)
Derivation and characterization of induced pluripotent stem cells from equine fibroblasts.
in Stem cells and development
Bruce A
(2013)
Novel GM animal technologies and their governance.
in Transgenic research
Burkard C
(2018)
Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection.
in Journal of virology
Bösze Z
(2008)
Producing recombinant human milk proteins in the milk of livestock species.
in Advances in experimental medicine and biology
Capocefalo A
(2009)
p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication.
in Journal of virological methods
Carlson DF
(2012)
Efficient TALEN-mediated gene knockout in livestock.
in Proceedings of the National Academy of Sciences of the United States of America
Chang SP
(2013)
Relative transgene expression frequencies in homozygous versus hemizygous transgenic mice.
in Transgenic research
Clark EL
(2017)
A high resolution atlas of gene expression in the domestic sheep (Ovis aries).
in PLoS genetics
| Description | A strategic approach to identifying and combating porcine reproductive and respiratory syndrome virus outbreaks and other porcine viral diseases |
| Amount | £787,016 (GBP) |
| Funding ID | BB/R013187/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | General Scheme - Bruce Whitelaw - Editing RELA S531P |
| Amount | £30,000 (GBP) |
| Organisation | Genus plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 12/2019 |
| Description | General Scheme - Christine Tait-Burkard - PRRSV study at Moredun to evaluate CD163 edited pigs |
| Amount | £48,812 (GBP) |
| Organisation | Genus plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2017 |
| Description | Research Grant - Christine Tait-Burkard - Nanobodies as antiviral PRRSV agents |
| Amount | £59,802 (GBP) |
| Organisation | Eco Animal Health Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | Research Grant - Simon Lillico - Application of genome editors for improved bioreactor productions - goats |
| Amount | £34,929 (GBP) |
| Organisation | BioSourcing SA |
| Sector | Private |
| Country | Belgium |
| Start | 03/2018 |
| End | 12/2018 |
| Description | Research Grant Simon Lillico - Application of genome editors for improved bioreactor production |
| Amount | £31,675 (GBP) |
| Organisation | BioSourcing SA |
| Sector | Private |
| Country | Belgium |
| Start | 05/2017 |
| End | 05/2018 |
| Description | Responsive Mode - Christine Tait-Burkard - Understanding the CD163 - PRRS virus interaction to improve genetic engineering for resistance |
| Amount | £674,353 (GBP) |
| Funding ID | BB/R004463/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2020 |