National Capability Grant - National Avian Research Facility
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This facility provides underpinning funding the National Avian Research Facility (NARF), a joint venture of The Roslin Institute (RI) and The Pirbright Institute (PI). The facility forms a national resource centre for experimental science of poultry and model avian species. The NARF, based at RI will comprise new Specified-Pathogen-Free and conventional avian facilities. This facility will provide specialist resources for avian biology research, ranging from basic developmental biology to research of direct value to the poultry breeding and production industry, and of benefit to human health through reducing food-borne zoonoses. At RI, our vision is to develop a research resource centre that will maintain and provide access to inbred and transgenic lines, transgenic and germ cell preservation technologies alongside genetic/genomic and gene expression analytical resources. This centre will be not just a unique resource centre for the UK, but a unique and world- leading centre, because of the wide range of facilities we will bring together. These resources will be available to the relevant UK research communities and also for international collaborations. NARF will benefit from input from ARK Genomics, as a centre for genomics and transcriptomics of a wide range of bird species, including inbred chicken lines, commercial poultry species and breeds and other key avian species of research interest. It will also integrate provision of other resources, for example the Chicken Gene Expression Atlas that is being developed with BBSRC funding, currently specifically to support developmental biology research. There are two components of the facility for which this NCG provides funding for: (1) support for the Transgenic Chicken Facility (TCF), including opportunities to work with the TCF to generate novel transgenic chickens and for access to material from established transgenic lines and (2) the infrastructure to maintain 8 inbred lines of chickens (although the cost of maintaining these lines will come from PI ISP/NCG funds), each of a single MHC haplotype, for studying basic immunology, vaccinology and the genetic contribution to traits of economic importance, particularly those associated with resistance and susceptibility to disease. These two aspects will also coincide in providing opportunities for generating transgenic birds in the specific genotypes of the inbred lines.
Planned Impact
unavailable
Organisations
- University of Edinburgh (Lead Research Organisation)
- UNIVERSITY COLLEGE LONDON (Collaboration)
- Cobb Vantress (Collaboration)
- Purdue University (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- Cherry Valley Farms (Collaboration)
- Aviagen Group (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- Fight for Sight (Collaboration)
- École Normale Supérieure, Paris (Collaboration)
- UNIVERSITY OF SHEFFIELD (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- University of Dundee (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- Charoen Pokphand Group (Collaboration)
- Royal Hospital for Sick Children Edinburgh (Collaboration)
- Albert Ludwig University of Freiburg (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- The Pirbright Institute (Collaboration)
People |
ORCID iD |
| David Hume (Principal Investigator) |
Publications
Alber A
(2019)
Dose-dependent differential resistance of inbred chicken lines to avian pathogenic Escherichia coli challenge.
in Avian pathology : journal of the W.V.P.A
Alber A
(2019)
Avian Pathogenic Escherichia coli (APEC) Strain-Dependent Immunomodulation of Respiratory Granulocytes and Mononuclear Phagocytes in CSF1R-Reporter Transgenic Chickens.
in Frontiers in immunology
Andersen JP
(2013)
No protection in chickens immunized by the oral or intra-muscular immunization route with Ascaridia galli soluble antigen.
in Avian pathology : journal of the W.V.P.A
Bailey IE
(2014)
Physical cognition: birds learn the structural efficacy of nest material.
in Proceedings. Biological sciences
Bain MM
(2013)
Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition.
in Animal genetics
Balic A
(2014)
Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage.
in Development (Cambridge, England)
Balic A
(2019)
Antigen Sampling CSF1R-Expressing Epithelial Cells Are the Functional Equivalents of Mammalian M Cells in the Avian Follicle-Associated Epithelium
in Frontiers in Immunology
Ballantyne M
(2021)
Avian Primordial Germ Cells Are Bipotent for Male or Female Gametogenesis.
in Frontiers in cell and developmental biology
| Description | National Avian Research Facility NCG. Objectives of this NCG were to develop conventional and specified pathogen-free (SPF) facilities to supply inbred and transgenic poultry, develop genomic resources for birds, and to preserve genetic resources via development of a frozen aviary. Both building phases were completed on time within budget. Inbred and outbred layer lines have been re-derived to SPF status at Roslin, enabling closure of the Compton laboratory. Such lines remain valuable resources to define the genetic and immunological basis of resistance to key avian and zoonotic pathogens and underpinned substantial uplift funding. Established transgenic lines (e.g. cytoplasmicGFP and membraneGFP) were supplied to over 24 laboratories all over the world resulting in over 50 papers in the reporting period. In collaboration with ISP2, NARF also supported the production of novel transgenic lines, including MacReporter chickens, ubiquitous TdTomato for transplantation studies, lox-stop-loxGFP for CRE recombinase-activated lineage tracing and splitGFP to trace virus infection by delivery of a complementary peptide by viruses that leads to GFP fluorescence in infected cells. Genome sequence data for 46 avian species has been made publicly available via the NARF website through in-house databases, together with re-sequencing, extensive RNA-Seq, SNP genotype and copy number variation data on all the lines held. To preserve genetic resources we have further developed primordial germ cell (PGC) technology and semen-freezing methods with support from ISP2. PGCs from inbred lines, rare breeds, and commercial stock have been successfully frozen and proven to be germline competent on implantation of thawed cells into embryos. Together with ISP2, NARF has supported the development of efficient methods for mutagenesis and transgenesis in PGCs and implantation into sterile recipients. NCG funding of the NARF has supported >100 publications since 2012. |
| Exploitation Route | The National Avian Research Facilities (NCG) continues to play a key role in our research to define the genetic and immunological basis of resistance to avian and zoonotic pathogens and in providing genome-engineered animals to study development and gene function (with ISP1 & ISP2). Many of the Avian resources developed during the NCG support continue to be maintained and used in collaborative projects within the Institute and wider in the research community (as evidenced by the extensive collaborations). The national flock of inbred lines housed within the NARF SPF unit (The Bumstead Building) provide a unique resource for the investigation of response to avian and zoonotic diseases. The facilities are imperative for continued core elements of Roslin research. Specific highlights of work supported by the NARF are the development of key transgenic lines. In transgenic MacReporter (CSF1R-reporter) chickens expression of the reporter gene provided a defined marker for chicken macrophage, monocytes and dendritic cells-lineage cells, identifying the earliest stages in the yolk sac, throughout embryonic development and in all adult tissues. Chickens lack lymph nodes and lymphoid tissues with equivalent function are difficult to visualise and isolate, which has made the isolation of cells and analysis of local immune responses especially difficult. The brightness and specificity of the CSF1R-reporter gene expression gives a unique macroscopic view of the organisation and extent of chicken lymphoid tissues, enabling simple identification of immune tissues and isolation of immune cells.The MacReporter chickens have been used extensively within the institute, and we are now in the process of developing this avian resource to make it available for wider use. Our second highlighted genetically modified line has been developed to facilitate both the development of gene edited or genetically modified chickens in addition to providing a key resource to enable the revival of cryopreserved chicken breeds. We used precision gene editing tools to produce a chicken with a mutation in the gene DDX4. When bred to homozygosity, the chicken does not produce any eggs. This sterile chicken can be used as a host recipient for the transplantation of oocytes from other breeds of chicken or modified primordial germ cells. When stem cells are transplanted into embryos from this chicken, the offspring produced will be from the stem cell host which can be either of a rare breed of chicken or genetically modified/gene edited. We have communicated these results to researchers maintaining poultry facilities in Europe and elsewhere to keep them abreast of these novel developments. In addition to the avian resources and facilities the NARF provides a defined hub for nationally-unique expertise in primordial germ cell technology and procedures for gene editing/genetic modification in poultry. |
| Sectors | Agriculture Food and Drink |
| Description | The development of technology around the cryopreservation of avian material or "the frozen aviary" has tremendous impact scientifically but equally important non-academic impacts in terms of preservation and regeneration of rare or "at risk" avian breeds. We have developed a genetically modified chicken that can be used to revive cryopreserved chicken breeds. Using precision gene editing tools we produced a chicken with a mutation in the gene DDX4. When an individual carries two copies of the mutant DDX4 gene it does not produce any of its own eggs. However, if we introduce primordial germ cells (PGCs) from a donor rare breed to a developing DDX4 embryo, the mature female will lay eggs from the donor rare breed. In conjunction with our ability to cryopreserve PGCs we have produced methods to cryopreserve and revive rare or "at risk" avian breeds. These development have been widely reported in the UK national press. Technology was further developed with the generation of a novel inducibly sterile surrogate host chicken. Introducing donor genome edited primordial germ cells into the sterile male and female host embryos produces adult chicken carrying only exogenous germ cells. Subsequent direct mating of the surrogate hosts, Sire Dam Surrogate (SDS) mating, recreates the donor chicken breed carrying the edited allele in a single generation. Our work with a large proportion of the major global avian breeding companies has enabled the development of tools and methodologies with the potential to complement and advance progress within commercial animal breeding programmes. These activities include the development of methods to explore the genetic basis of Avian Influenza and Salmonella Typhimurium susceptibility/resistance in collaboration with Hy-Line International; exploring methods to determine eggshell cuticle quality with Lohmann tierzucht/Aviagen Ltd "Cute-Egg, improvement of eggshell cuticle quality to reduce vertical transmission of zoonotic and pathogenic organisms"; understanding the genetic basis of campylobacter infection in broilers with Aviagen Ltd "A systems-wide approach to the control of Campylobacter in the food chain: exploiting genetic variation" and "Mapping resistance to Campylobacter in the chicken"; and understanding resistance to Eimeria infections in collaboration with Cobb-Vantress "Understanding resistance and differential vaccine responses to Eimeria in the chicken - novel biomarkers and genetic control." and "The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken". These collaborative projects have the potential to improve animal health, welfare and productivity, grow UK business and because of the scale of the international companies we collaborate with, these projects have the potential to elicit a significant impact on the global avain food safety and security. |
| First Year Of Impact | 2014 |
| Sector | Agriculture, Food and Drink,Environment |
| Impact Types | Societal Economic |
| Description | FAO: methods paper on Biobanking of Livestock animals |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://www.fao.org/documents/card/en/c/cc3078en |
| Description | WPSA European Federation Working Group - WG3 Breeding and Genetics |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.wpsa.com/index.php/breeding-and-genetics-wg-3 |
| Description | 100 years of Animal Genetics - Engagement across Scotland |
| Amount | £35,137 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 12/2018 |
| Description | ANIHWA call 2: Better bone quality in laying hens |
| Amount | £836,262 (GBP) |
| Funding ID | BB/M028291/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 10/2018 |
| Description | ANIHWA call1 TURKEYWELFARE |
| Amount | £75,281 (GBP) |
| Funding ID | BB/L012022/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 02/2016 |
| Description | Accelerating advances in animal welfare |
| Amount | $486,594 (USD) |
| Funding ID | 550396 |
| Organisation | Foundation for Food and Agriculture Research |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2018 |
| End | 03/2022 |
| Description | Agri-tech Catalyst |
| Amount | £850,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 01/2018 |
| Description | An Institute Strategic Support Fund (ISSF3). |
| Amount | £35,000 (GBP) |
| Funding ID | ISSF3 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | BBSRC - Responsive mode research grants |
| Amount | £590,000 (GBP) |
| Funding ID | BB/R003653/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 11/2020 |
| Description | BBSRC ANIWHA call 2 |
| Amount | £428,690 (GBP) |
| Funding ID | BB/M028305/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | BBSRC Industrial Partnering Award |
| Amount | £1,500,000 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 09/2020 |
| Description | BBSRC Industrial Partnering Award Scheme |
| Amount | £516,308 (GBP) |
| Funding ID | BB/J015296/1 (Role of AKT1 & SIVA1 in resistance to avian salmonellosis) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2015 |
| Description | BBSRC LINK with AB Vista |
| Amount | £830,000 (GBP) |
| Funding ID | BB/M020738/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 08/2018 |
| Description | BBSRC Responsive mode |
| Amount | £450,000 (GBP) |
| Funding ID | BB/K005642/1 (A novel bacterial defence system against antimicrobial peptides: Implications for host colonisation in the foodborne pathogen Campylobacter jejuni) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 12/2016 |
| Description | BBSRC Sparking Impact & AB Vista |
| Amount | £14,765 (GBP) |
| Funding ID | The development of novel egg peptides as antimicrobial feed additives for poultry |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2013 |
| Description | BBSRC Strategic LoLa scheme |
| Amount | £5,700,000 (GBP) |
| Funding ID | BB/N001591/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2021 |
| Description | BBSRC-NIFA |
| Amount | £417,191 (GBP) |
| Funding ID | BB/M028208/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | BBSRC-NIFA scheme for UK-US collaboration on animal diseases |
| Amount | £800,000 (GBP) |
| Funding ID | BB/M028208/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | British Society for Developmental Biology PI Award |
| Amount | £1,000 (GBP) |
| Organisation | British Society for Developmental Biology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 04/2017 |
| Description | British Society for Developmental Biology Travel Award |
| Amount | £1,000 (GBP) |
| Organisation | British Society for Developmental Biology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 04/2017 |
| Description | British Society for Developmental Biology Travel Award |
| Amount | £500 (GBP) |
| Organisation | British Society for Developmental Biology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 04/2017 |
| Description | British Society for Surgery of the Hand Research Grant |
| Amount | £2,000 (GBP) |
| Organisation | British Society for Surgery of the Hand (BSSH) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 08/2016 |
| Description | Company of Biologist Small Meeting Grant |
| Amount | £3,000 (GBP) |
| Organisation | Company of Biologists |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 07/2017 |
| Description | Cute-Egg, improvement of eggshell cuticle quality to reduce vertical transmission of zoonotic and pathogenic organisms |
| Amount | £603,775 (GBP) |
| Funding ID | BB/K007092/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 09/2016 |
| Description | Edinburgh Gallus Genome and Embryonic Development Workshops (EGGED Workshops) |
| Amount | £14,941 (GBP) |
| Funding ID | 1933 |
| Organisation | Royal Society of Edinburgh (RSE) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2023 |
| Description | Edinburgh Gallus Genome and Embryonic Development Workshops (EGGED Workshops) Small Meeting Grant |
| Amount | £4,000 (GBP) |
| Organisation | Company of Biologists |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2022 |
| End | 08/2022 |
| Description | Flexible Talent Mobility Award collaboration on poultry welfare traits |
| Amount | £4,000 (GBP) |
| Funding ID | R46184 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2020 |
| Description | GENE-SWitCH |
| Amount | € 5,999,886 (EUR) |
| Funding ID | SEP-210522342 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 06/2019 |
| End | 06/2023 |
| Description | Gene targeting of primordial germ cells using TALEN technology to generate the first knockout transgenic chickens |
| Amount | £102,263 (GBP) |
| Funding ID | BB/L018063/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 09/2015 |
| Description | Genome-wide mapping and identification of genes controlling resistance to Marek's Disease virus infection in commercial layer chickens |
| Amount | £637,160 (GBP) |
| Funding ID | BB/K006916/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2013 |
| End | 10/2016 |
| Description | ISSF3- "The control of tempo during embryonic development: insights from hybrid vertebrates" |
| Amount | £30,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 06/2020 |
| Description | Investigating how the type and quantity of food affect foraging behaviour and the neural circuits controlling feeding in broiler breeder chickens |
| Amount | £195,449 (GBP) |
| Funding ID | BB/L000199/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Macrophage Biology and Disease Susceptibility in Poultry |
| Amount | £761,555 (GBP) |
| Funding ID | BB/M011925/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 11/2018 |
| Description | Novel approaches to define tissue fusion mechanisms in embryonic development |
| Amount | £874,217 (GBP) |
| Funding ID | MR/S033165/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 08/2023 |
| Description | Responsive Mode - Adam Balic - Exploitation of new technologies to advance understanding of avian dendritic cell biology |
| Amount | £589,932 (GBP) |
| Funding ID | BB/R003653/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2020 |
| Description | Rooney Foundation Grant |
| Amount | £1,000 (GBP) |
| Organisation | William Rooney Plastic Surgery & Burns Research Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 08/2016 |
| Description | Scottish Government RESAS initiative |
| Amount | £900,000 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Sex-determining mechanisms in the chick |
| Amount | £454,406 (GBP) |
| Funding ID | BB/N018672/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2020 |
| Description | Society Development Biology Meeting Award |
| Amount | $4,000 (USD) |
| Organisation | Society-Developmental Biology |
| Sector | Learned Society |
| Country | United States |
| Start | 06/2017 |
| End | 07/2017 |
| Description | Sub-award from ISCF Transforming Food Production Seeding Award (ISCF-TFP-SA-Edinburgh). Dr Adam Balic 'Generation of a Cas9 chicken as a platform to identify causative production alleles for application in breeding programmes;. |
| Amount | £17,848 (GBP) |
| Funding ID | ISCF-TFP-SA-Edinburgh |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 02/2019 |
| Description | The evolution and diversity of endogenous retroviral genomes in chicken brown and while egg layer populations |
| Amount | £93,520 (GBP) |
| Funding ID | BB/K010964/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2017 |
| Description | Understanding resistance and differential vaccine responses to Eimeria in the chicken - novel biomarkers and genetic control. |
| Amount | £379,303 (GBP) |
| Funding ID | BB/L004003/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 08/2017 |
| Description | Whitaker International Program |
| Amount | $100,000 (USD) |
| Organisation | Whitaker International Program |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 04/2016 |
| End | 04/2018 |
| Description | he role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken. |
| Amount | £1,144,442 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 12/2020 |
| Title | A sterile surrogate host chicken that can be used to revive cryopreserved chicken breeds |
| Description | We have developed a genetically modified chicken that can be used to revive cryopreserved chicken breeds. We used precision gene editing tools to produce a chicken with a mutation in the gene DDX4. When bred to homozygosity, the chicken does not produce any eggs. This sterile chicken can be used as a host recipient for the transplantation of oocytes from other breeds of chicken. When stem cells from a rare chicken breed are transplanted into embryos from this chicken, the offspring produced will be from the rare breed of chicken. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This research has led to a publication in a major scientific journal. Many press articles reported this discovery and reported the positive uses of gene editing technology for preserving rare breeds of chicken. We have communicated these results to our Japanese partner of our Japan Partner Award. This chicken is currently being used tested in an Innovate UK project to develop and resurrect a rare breed of chicken. |
| URL | https://www.theguardian.com/science/2017/feb/17/sterile-genetically-modified-chickens-protect-rare-b... |
| Title | Antibody - Tim4 antibody |
| Description | A monoclonal antibody directed against chicken TIM4, a receptor for phosphatidylserine. Phosphatidylserine is expressed on the surface of apoptotic cells. Therefore this monoclonal antibody stains cells that interact with apoptotic cells. |
| Type Of Material | Antibody |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | In liver, highly-phagocytic TIM4hi cells shared many transcripts with mammalian Kupffer cells and were associated with uptake of apoptotic cells. TIM4 is associated with phagocytes that eliminate apoptotic cells in the chick. In the liver, TIM4 and CSF1R reporters distinguished Kupffer cells from an abundant population of DC-like cells. |
| URL | http://www.jimmunol.org/content/early/2019/01/08/jimmunol.1800504 |
| Title | Chicken line for investigating sex determination |
| Description | chicken line with edited sex-determining gene |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | N/A |
| Title | Flt3 antibody |
| Description | A monoclonal antibody against chicken Flt3. Flt3 is the receptor for the major dendritic cell growth factor Flt3 ligand. |
| Type Of Material | Antibody |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Publication near completion. Antibody will be made available to other researchers upon publication |
| Title | High speed integrated spectrophotometer and analysis tool, eCutimeter |
| Description | Custom designed system for the rapid assessment of cuticle deposition using spectrophotometry. The final 'production' prototype was capable of rapid measurement across a range of wavelengths but was designed principally for high throughput reflectance measurement of eggs which would be used for cuticle measurement by staining. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The machine is in trial at breeding organisations with a view to assessing its incorporation into breeding practice. |
| Title | Lines of edited PGCs for investigating germ cell development |
| Description | Lines of edited PGCs for investigating germ cell development |
| Type Of Material | Cell line |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | N/A |
| Title | prototype egg cuticle measurement device |
| Description | Device to hold rotate and measure surface fluorescence of an egg |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Ability to conduct measurements for genetic evaluation . |
| Title | Avianbase: a community resource for bird genomics |
| Description | The Avianbase Project is an initiative led by the Roslin Institute in collaboration with the Avian Phylogenomics Consortium and Ensembl to make the initial sequence and annotation available for 48 bird species within the Ensembl framework. The Avianbase Project is using the Ensembl infrastructure to share data brought together by the Avian Phylogenomics Consortium (as part of the Avian Genome Consortium) for 48 birds. Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | The Avianbase project was overviewed in the paper of 2015 (Lél Eöry, M Thomas P Gilbert, Cai Li, Bo Li, Alan Archibald, Bronwen L Aken, Guojie Zhang, Erich Jarvis, Paul Flicek and David W Burt (2015) Avianbase: a community resource for bird genomics. Genome Biology 16:21) which has been sited by over 18 times. It provides a valuable one-stop-shop to access a wealth of Avian genomic information to allow easy interrogation of genotype across species. |
| URL | http://avianbase.narf.ac.uk/index.html |
| Title | Development of an in vivo radiographic method with potential for use in improving bone quality and the welfare of laying hens through genetic selection. |
| Description | Citation Dunn, Ian; Wilson, Peter; McCormack, Heather. (2022). Development of an in vivo radiographic method with potential for use in improving bone quality and the welfare of laying hens through genetic selection., 2018-2019 [dataset]. University of Edinburgh, The Roslin Institute. https://doi.org/10.7488/ds/3484. Data from the measurement of bone density of laying hens using post mortem density and quasi static material testing and live bird x-ray derived density estimates. This is for the validation of live bird x-ray as a potential tool for genetic selection. A reproducability/repeatability study and a manipulation of skeletal quality experiment are included and a SOP for the performance of the technique to allow replication and to give more data than in the paper this accompanies. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Further grant funding and the methodology is used for genetic appraisal. |
| URL | https://doi.org/10.7488/ds/3484 |
| Description | Aviagen |
| Organisation | Aviagen Group |
| Country | United States |
| Sector | Private |
| PI Contribution | As a former Aviagen employee I continue to engage with current members of Aviagen's R&D group. Together we have partnered on one unsuccessful research application which would have utilized the NARF avian resources and facilities. |
| Collaborator Contribution | Working with key members of the R&D team at Aviagen, we are able to access commercial know-how and the considerable IP associated with commercial genetic resources. |
| Impact | Grant application BB/R003467/1 |
| Start Year | 2016 |
| Description | Aviagen |
| Organisation | Aviagen Group |
| Country | United States |
| Sector | Private |
| PI Contribution | We are working with Aviagen to explore the role of the chicken gut microbiome in performance of their chickens in diverse environments. So far this includes the placement of one of their staff members in my group for a short period of time for training and development |
| Collaborator Contribution | Aviagen provide access to large commercial flocks of chickens under both controlled and natural environments |
| Impact | No outputs so far |
| Start Year | 2017 |
| Description | Charoen Pokphand (CP) group |
| Organisation | Charoen Pokphand Group |
| Country | Thailand |
| Sector | Private |
| PI Contribution | Charoen Pokphand (CP) group are a large Asian conglomerate with an interest in farming, food production and feed additives. They have placed one of their staff members with me for PhD training, fully funded by them. We are training the staff member in laboratory and bioinformatics techniques related to microbiome research in chickens. |
| Collaborator Contribution | CP provide access to large chicken flocks both in at their farms and in their production facility. This enables us to study chicken breeds in the actual environments in which they live throughout Asia. |
| Impact | This is a multi-disciplinary project involving both laboratory and computational techniques. The major outcome so far include a review paper (http://aem.asm.org/content/early/2018/01/29/AEM.02627-17.abstract) and the technology transfer from our group into the commercial partner. |
| Start Year | 2017 |
| Description | Cherry Valley Farms |
| Organisation | Cherry Valley Farms |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | There has been an ongoing partnership to develop genomic breeding programme for Cherry Valley Farms (CVF) including strategies to improve the genomic assembly for the Pekin Duck. This collaboration has led to one current grant application (successful Innovate UK) and other planned applications in the future. |
| Collaborator Contribution | Cherry Valley Farms have provided genomic material from within all their current selection lines to enable the analyses of genetic diversity in Pekin Ducks which supply a significant proportion of global commercial duck production. |
| Impact | Generation of significant genomic information; development and production of low density SNP panel; successful Innovate UK funding application. |
| Start Year | 2016 |
| Description | Cobb-Vantress Roslin partnership agreement |
| Organisation | Cobb Vantress |
| Country | United States |
| Sector | Private |
| PI Contribution | Continued grant meetings reporting project results to Cobb-Vantress. Discussions on publishing and filing patent applications. |
| Collaborator Contribution | Continued grant meetings reporting project results to Cobb-Vantress. Discussions on publishing and filing patent applications. |
| Impact | Publications, press releases, student training, postdoctoral training. webinars. |
| Start Year | 2014 |
| Description | Collaboration with Aviagen Ltd |
| Organisation | Aviagen Group |
| Country | United States |
| Sector | Private |
| PI Contribution | The project was funded via the BBSRC LINK scheme and involved a close collaboration with Aviagen Ltd, part or the Erich Wesjohann Group and a major global breeder of poultry. In broad terms, the project sought to define the genetic basis of avian resistance to Campylobacter colonisation. This involved genome-wide association studies using the progeny of crosses of inbred lines that differ in heritable resistance to Campylobacter (specifically backcross and advanced inter-cross populations derived from lines 6 and N), and identified quantitative trait loci (QTL) associated with resistance (Psifidi et al. 2016). The project also involved a genome-wide association study using over 3000 Aviagen broilers in a simulated field context. High quality genotypes and Campylobacter colonisation phenotypes were identified for 2750 broilers and QTL associated with resistance were identified, two of which were shared with the study using inbred lines (manuscript in preparation). Studies to validate QTL and understand how they exert their effect are ongoing with core funding from the BBSRC and a grant from the Scottish Government. |
| Collaborator Contribution | As above. Aviagen provided access to its flocks and expertise, as well as costs for genotyping and validation of QTL. |
| Impact | See publications & additional funding sections of this return. By defining the genomic architecture of avian resistance to Campylobacter our studies will inform the scope to breed selectively for birds with improved control of an important zoonotic pathogen. Our studies show that a relatively modest proportion of the variation in the trait (caecal C. jejuni numbers) can be explained by bird genetics and that resistance-associated QTL are already prevalent in the commercial broiler line studied. Work is ongoing to validate the associations between QTL and Campylobacter levels, and understand how they exert their effect. There is scope for long-term societal gain from the research as chicken continues to be the primary reservoir of human campylobacteriosis. |
| Start Year | 2012 |
| Description | Collaboration with Brian Brooks - Director, National Eye Institute. NIH |
| Organisation | National Institutes of Health (NIH) |
| Department | National Eye Institute (NEI) |
| Country | United States |
| Sector | Public |
| PI Contribution | Establishing the use of chick as a model for vertebrate structural eye development. This is novel and complements other groups use of alternative models (zebrafish and mouse) for understanding human eye development. In particular, our strengths are the investigation of structural development, such as optic fissure closure and anterior segment and iris development. |
| Collaborator Contribution | Professor Brooks is the Director of The National Eye Institute. (NIH, US). His group is focused on the identification of mutations in genes that cause structural eye defects, and uses zebrafish to model genetic defects. |
| Impact | Currently we have a manuscript in preprint, detailing the identification of a novel coloboma associated gene and the transcriptional landscape of tissue fusion in the embryonic chicken eye. |
| Start Year | 2017 |
| Description | Collaboration with Dr Mark Fife at The Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was the lead applicant on this BBSRC proposal and the postdoctoral researcher deployed on the project was responsible for delivery of stated objectives. |
| Collaborator Contribution | Dr Fife was a co-Investigator in this proposal and has played the leading role in genome-wide association studies investigating the basis of avian resistance to fowl typhoid. This has involved investigation of two naturally-occurring outbreaks for which he attracted an additional funding from Hy-Line for genotyping. |
| Impact | We have been invited to submit a manuscript to Frontiers in Genetics in Spring 2018 related to the genome-wide association studies to map quantitative trait loci for fowl typhoid resistance in commercial layers. |
| Start Year | 2011 |
| Description | Collaboration with Mariya Moosajee |
| Organisation | University College London |
| Department | Institute of Ophthalmology UCL |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are identifying novel genes expressed during tissue fusion through combining transcriptomic datasets from multiple vertebrates. We are using Spatial gene expression in chicken embryos. |
| Collaborator Contribution | Acquisition and analysis of transcriptome data from zebrafish eye tissues. Variant searching in 100,000 genomes project. Spatial gene expression in zebrafish embryos. |
| Impact | None yet |
| Start Year | 2020 |
| Description | Collaboration with Prof. Jim Kaufman |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A long term collaboration where I bring expertise of the structure and understanding of commercial breeding programmes. |
| Collaborator Contribution | With focus on the MHC, JK has helped with understanding the basis of MHC haplotype in existing bird lines. General understanding of MHC in avians. |
| Impact | Generation of data and papers in draft. |
| Start Year | 2016 |
| Description | Collaboration with Prof. Marco Prinz |
| Organisation | Albert Ludwig University of Freiburg |
| Department | Institute of Neuropathology |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Collaboration with Marco Prinz, Professor of Neuropathology at the University of Freiburg, Germany. |
| Collaborator Contribution | Cross-species analysis of gene expression in microglia, the brain-resident macrophage population. We isolated and generated data on chicken microglia. Our partners combined these resources with that of many other species to perform a large scale analysis of gene expression in microglia. |
| Impact | Geirsdottir et al., Cell. 2019. 179(7):1609-1622.e16. PMID: 31835035 |
| Start Year | 2018 |
| Description | Collaboration with Professor Dave Kelly, University of Sheffield |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a joint project led by Professor Dave Kelly at the University of Sheffield. Our component involved testing the ability of Campylobacter mutant strains lacking specific genes to colonise the intestines of chickens relative to the parent strain. Additionally, we established a Galleria mellonella 3R model to evaluate virulence of the strains. |
| Collaborator Contribution | Provision of strains & expertise. |
| Impact | Phenotypes for a series of mutant strains lacking specific genes, singly and in combinations, from chicken and Galleria models. |
| Start Year | 2012 |
| Description | Collaboration with RVC - Eimeria |
| Organisation | Royal Veterinary College (RVC) |
| Department | Pathobiology and Population Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaborative projects to explore the genetic/phenotypic basis of response to Eimeria challenge in poultry. Our expertise is in basic poultry biology and analysis of data to determine the underlying genetic basis of response. |
| Collaborator Contribution | Our partners at RVC have in depth understanding of the pathogen Eimeria and how this impacts the bird. In addition they have technical expertise in managing challenge experiments. |
| Impact | To date there has been publications and generation of significant data. |
| Start Year | 2017 |
| Description | Collaboration with United States Department of Agriculture |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | USDA are partners in this BBSRC US-UK Partnering Award related to Salmonella and E. coli infections in food-producing animals. We have shared expertise, ideas & materials. A co-Investigator at the Roslin Institute (Professor John Hopkins) visited USDA researchers to transfer his expertise in surgical cannulation of lymphatic vessels, to allow the team to gain access to Salmonella and immune cells as they migrate from the intestines of cattle. |
| Collaborator Contribution | Shared expertise, ideas & materials. |
| Impact | Not at this stage. |
| Start Year | 2014 |
| Description | Collaboration with United States Department of Agriculture |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | USDA are partners in this BBSRC US-UK Partnering Award related to Salmonella and E. coli infections in food-producing animals. We have shared expertise, ideas & materials. A co-Investigator at the Roslin Institute (Professor John Hopkins) visited USDA researchers to transfer his expertise in surgical cannulation of lymphatic vessels, to allow the team to gain access to Salmonella and immune cells as they migrate from the intestines of cattle. |
| Collaborator Contribution | Shared expertise, ideas & materials. |
| Impact | Not at this stage. |
| Start Year | 2014 |
| Description | Developmental basis of Radial Aplasia |
| Organisation | Royal Hospital for Sick Children Edinburgh |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | My research team at The Roslin Institute are developing an animal model of radial aplasia. We provide unique transgenic animal facilities, specialist skills in embryonic manipulation and the majority of intellectual contribution, understanding the developmental basis of congential radial aplasia. |
| Collaborator Contribution | Mr W L Lam provides the insight of human congenital limb abnormalities |
| Impact | As a result of this collaboration I have be invited to speak at several major limb surgical conferences, which has improved the communication between the clinical and scientific fields. Following this Mr WL Lam (consultant plastic surgeon, limb surgery) and myself (lead scientist) organised the first 'Clinical Workshop' at the 14th International Conference on Limb Development and Regeneration Meeting 2017 to formalize the links between the Developmental biology and Clinical Limb Surgery fields. We have established that the Clinical field lacks understanding of genetic diagnosis and fundamental biology underpinning congenital limb malformations so at this conference we including world leading leading speakers on genetic diagnosis of human congenital diseases. We have obtained funding from the British Society for Developmental Biology, The British Society for Surgery of the Hand and The Rooney Foundation to develop this project. This is a reflection on the increasing importance this collaboration has for clinical understanding of congenital disorders. We have joint published a book chapter on limb development. We have published a joint paper proposing a model to explain the developmental basis of radial aplasia. |
| Start Year | 2015 |
| Description | Donna Fekete. Purdue University, Indiana, US. |
| Organisation | Purdue University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I share resources, methodologies and data pertaining to the delivery of exogenous gene constructs into the developing chicken embryo, and details of their impact on embryonic tissue fusion events. |
| Collaborator Contribution | They reciprocally share resources, methodologies and data pertaining to the delivery of exogenous gene constructs into the developing chicken embryo, and details of their impact on embryonic tissue fusion events. |
| Impact | None as yet. |
| Start Year | 2019 |
| Description | Elucidating the mechanisms of optic fissure closure and human coloboma with Joe Rainger, Fight for Sight Fellow |
| Organisation | Fight for Sight |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Dr Joe Rainger developed this project in collaboration with the Davey Lab, moving from understanding the mechanisms of optic fissure closure in mammals to chicken. Dr Rainger has undertaken the fellowship with the Davey group and with technical and intellectual support from Megan Davey, who also provides training for Dr Rainger and his student as well as providing space and equipment. |
| Collaborator Contribution | Dr Rainger brings expertise in mechanism of embryonic eye growth and development, elucidation of novel loci causing coloboma and knowledge of the Actin cytoskeleton. Dr Davey provides mentoring, training in chicken developmental techniques and |
| Impact | • Rainger J, Williamson KA, Soares DC, Truch J, Kurian D, Gillessen-Kaesbach G, Seawright A, Prendergast J, Halachev M, Wheeler A, McTeir L, Gill AC, van Heyningen V, Davey MG; UK10K, FitzPatrick DR.(2017) A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. PMID: 28493397. We have secured funding for a joint PhD student. We have co-organised an international developmental biology meeting (Joint BSDB/Nordic Conference on Developmental Biology and Regeneration 2017). |
| Start Year | 2015 |
| Description | Evaluation and validation of membraneGFP transgenic embryos for in vivo imaging |
| Organisation | University of Dundee |
| Department | School of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed a lentiviral vector to deliver a transgene designed to express membrane-localised Green Fluorescent Protein (GFP) ubiquitously in chicken embryos. We generated a transgenic line carrying this vector and provided chicken embryos to the Weijer lab for them to evaluate and develop in vivo imaging technologies. |
| Collaborator Contribution | The Weijer lab advised on transgene design and developed in vivo imaging using light sheet microscopy. |
| Impact | This collaboration lead to a publication Rozbiki et al. (2015) Nature Cell Biology 17, 397-408 and the use of this research tool in the Weijer lab is ongoing, funded by new grants. |
| Start Year | 2012 |
| Description | Evaluation of Notch-reporter transgenic embryos |
| Organisation | École Normale Supérieure, Paris |
| Department | Institute of Biology |
| Country | France |
| Sector | Academic/University |
| PI Contribution | We developed a line of transgenic chickens carrying a transgene that would express green fluorescent protein as a reporter of notch signalling activity. |
| Collaborator Contribution | The partners utilised embryos from this line to exemplify its utility in experiments to understand vertebrate embryo development. |
| Impact | A paper has been published. |
| Start Year | 2016 |
| Description | ILRI |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | We work with ILRI on all aspects of genomics and data science, including whole genome sequencing of multiple African animals, data recording and database design, web and web content development, and bioinformatics training. |
| Collaborator Contribution | We work with ILRI on all aspects of genomics and data science, including whole genome sequencing of multiple African animals, data recording and database design, web and web content development, and bioinformatics training. |
| Impact | So far we have sequenced the genomes of approx 800 African farm animals from diverse breeds and ecotypes |
| Start Year | 2016 |
| Description | Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided avian material to support the research efforts across multiple groups at the Pirbright institute. The Director of the NARF attends poultry user meetings at the Pirbright to ensure we are able to continue to support ongoing research needs. |
| Collaborator Contribution | The recipients of material provide feedback on the quality and performance of the avian materials to help us ensure continued quality. We are in close contact regarding the development of future avian resources to specifically support the Pirbright research requirements. |
| Impact | Supply of avian material to support ongoing research! |
| Start Year | 2012 |
| Title | Addition of new gene associated with eye disorder into molecular diagnostic screening panel in scottish NHS |
| Description | Identification of mutations in ACTG1 gene led to its inclusion in medical diagnostic screens for patients with inherited eye malformations |
| Type | Management of Diseases and Conditions |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2017 |
| Development Status | Closed |
| Impact | Refinement of known disease genes for ocular birth defects |
| Company Name | Roslin Technologies |
| Description | Roslin Technologies utilises biotechnology to develop sustainable food products, to combat the issues of food security, animal health and environmental change. |
| Year Established | 2016 |
| Impact | Roslin Technology (commercial partner of Roslin Institute) is currently offering a commercial biobanking service to the poultry industry to biobank commercial chicken flocks using the technology partially developed in this grant. The commercial partner of this grant, Cobb Vantress, Inc, has granted Roslin Technology the right to commercially exploit the non-patentable IP from this project and has made use of this commercial biobanking service offered by Roslin Technology. I, Mike McGrew, am a consultant for the commercial biobanking service. |
| Website | http://www.roslintech.com |
| Description | "Application of proteins to chicken embryos via beads", Avian Research Symposium, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented work of ISP1/2 highlighting novel transgenic chicken lines produced at The Roslin Institute |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Birds have dinosaur feet- why counting toes matters", TAMU, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented research from ISP1/2 highlighting the novel transgenic chicken resources developed at The Roslin Insitute |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Determining the Interacting Network of TALPID3 through Proteomic Studies" Cold Spring Harbour Centrosome Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A description of work discovering the fundamental proteins involved in action of the centrosome via chicken mutants |
| Year(s) Of Engagement Activity | 2017 |
| Description | "Fate mapping the limb using Chameleon"- Julia Oh 14th ICLDR |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk describing the use of The Roslin Institute transgenic bird lines and their uses. |
| Year(s) Of Engagement Activity | 2017 |
| Description | "From Barnyard to Bedside- A modern age story of genomics and genome engineering" Royal Society of Biology Annual Teacher's Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | I presented the novel work undertaken in ISP1/2 including new genome engineering approaches used at The Roslin Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | "How Do Fingers and Toes Grow?", Biomedical and Life Sciences, Lancaster University, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented work of ISP1/2 highlighting novel transgenic chicken lines produced at The Roslin Institute |
| Year(s) Of Engagement Activity | 2021 |
| Description | "New Tools and New Ideas for a Classic Model System", EMBO Workshop: Limb Development and Regeneration Conference, Spain |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited talk at International Limb Development and Regeneration Meeting at which I presented work based on novel transgenic chicken lines |
| Year(s) Of Engagement Activity | 2019 |
| Description | "Spots, Stripes and Rainbows" Avian Systems Meeting 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk describing the use of The Roslin Institute chicken transgenic lines to a scientific audience |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Using the developing choroid plexus to explore cilia transcriptomics" Cold Spring Harbour |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk to 120 scientists about the use of transcriptomics to understanding ciliogenesis |
| Year(s) Of Engagement Activity | 2017 |
| Description | "Walking with the Feet of Dinosaurs" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | 40 undergraduate students from the University of Edinburgh Zoological Club attended the talk. Subsequently students came to undertake research at The Roslin Institute |
| Year(s) Of Engagement Activity | 2017 |
| Description | "Where did the 5th Toe Go" University of Basel |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk describing the use of The Roslin Institute transgenic bird lines and their uses. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Where did the 5th Toe Go?" 14th ICLDR |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk describing the use of The Roslin Institute transgenic bird lines and their uses. |
| Year(s) Of Engagement Activity | 2017 |
| Description | 24th Annual Meeting of Biology Teachers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A forward looking discussion on the role of genetic selection and genome engineering in order to update biology teachers on new technologies |
| Year(s) Of Engagement Activity | 2019 |
| Description | 32nd Leeds Symposium on Food History and Traditions, York, UK( April 2017) "Birds for the Table", I presented a lecture entitled "Chykenns in cawdel to KFC: development of the modern broiler chicken". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I organised the theme and guest list for the 32nd Leeds Symposium on Food History and Traditions, York, UK ( April 2017) "Birds for the Table". I also presented a lecture entitled "Chykenns in cawdel to KFC: development of the modern broiler chicken. The purpose of this talk was to communicate how the modern broiler chicken was developed from earlier chickens and red jungle fowl ancestors; and how modern broiler production is managed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | ARS 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Jacqueline Smith presented a keynote talk at the Avian Researc Symposium 2023 (Edinburgh) - 'The avian genome: the current state of play' |
| Year(s) Of Engagement Activity | 2023 |
| Description | BUAS Schools Countryside Day 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Primary 5 children and teachers from the entire Scottish Borders region. Ran activities around the cuticle and its importance. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.flickr.com/photos/scottishborderscouncil/albums/72177720308337706/ |
| Description | Biobanking in Southeast Asia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation by my post-doctoral scientist (Jun Hu) on this research project and adapting the results for use in Southeast Asia |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ilri-org.zoom.us/webinar/register/WN_Rq8re9lqTG6Twgd08Ll-Vw |
| Description | Cafe Scientifique, Brighton Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk in the Brighton Science Festival October 27 2018, "Genome editing in agriculture - a new apprpach or still GM?". Broad audience of engaged public including students from an access course, who engaged in long question/answer and discussion session after talk. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.brightonscience.com/events/genome-editing-in-agriculture/ |
| Description | Communicating science to lay audiences |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Pint of Science: Why eye can see. Described birth defects affecting the eyes and how they can arise and how we are able to genetically diagnose them, with a view to opportunities for disease management and potential therapies. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://pintofscience.co.uk/event/why-eye-can-see |
| Description | Conference Organiser- The 14th Limb Development and Regeneration Meeting Clinical Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | As an addition to the 14th Limb Development and Regeneration Conference, I organised a Clinical Workshop to engage the specialist discipline of congenital hand/foot surgeons, to better integrate the clinical aspects of limb development with the developmental biology. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ed.ac.uk/igmm/news-and-events/events/latest-events/limb-development-2017 |
| Description | Edinburgh scientists working to create safer eggs |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | News coverage of egg cuticle story. 'Cute egg' |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-43605254 |
| Description | Evonik research day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I presented my work on precision analysis of microbiomes to Evonik, an international company with over 13000 employees and with interests in chemical and food production. This was part of a one day workshop with Evonik, hosted by Roslin and focused on microbiomes |
| Year(s) Of Engagement Activity | 2018 |
| Description | Fast embryos- slow embryos. Understanding 'developmental tempo' using chickens", Incubation and Fertility Research Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The Keynote talk at the international Incubation and Fertility Research Group - an industry based conference in avian production, which increased awareness of embryonic development traits which could form breeding strategies |
| Year(s) Of Engagement Activity | 2021 |
| Description | Feature for BBC2 Food Detectives programme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Stevens took part in a BBC2 Food Detectives programme which featured Campylobacter in chickens. He helped to design a survey of Campylobacter contamination in a sample of fresh chicken obtained from Scottish retailers and interpret the findings. This were close to Food Standards Agency findings, which were broadcast as part of an interview with Prof. Alice Roberts. The interview took place at The Roslin Institute and included a lay description of Campylobacter, the importance of chickens as a reservoir of infection and strategies by which consumers can protect themselves. It also highlighted BBSRC-funded work at Roslin to mitigate the problem based on genetic selection (this project) and vaccines (other BBSRC projects held by Prof. Stevens). |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b077rgd4 |
| Description | Interview for international news_The Atlantic |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press interview on a recent publication that was printed in the online magazine, The Atlantic. The reach of this journal is international and substantial |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.theatlantic.com/science/archive/2019/10/frozen-aviary/600271/ |
| Description | Invited lecture at MSD-Animal Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited lecture at MSD-Animal Health in Boxmeer the Netherlands, with WebEx connection to all other location o MSD -AH around the world. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecture at the annual BSI meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave an invited lecture in the session Immune surveillance and lymphoid tissue architecture at the annual BSI congress in Liverpool. It sparked questions and request fo further info and collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bsicongress.com/sessionspeakers |
| Description | Invited speaker - Avian Genetics and Immunity Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research on Avian Genetics and Immunity (RAGI) has been established to strengthen global partnerships and links between academic researchers, students and the poultry professionals working on the genetics of avian immunity. The purpose of the symposium was to provide a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities in ultimately dealing emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health. The purpose of KW talk was to overview the current situation in industry for breeding for disease resistance and introduce the NARF. The overview of NARF included a review of facilities, lines available and current work being carried out using NARF avian lines. The presentation stimulated significant discussion. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://geneticsandimmunity.com/ |
| Description | Invited speaker - society of feed technologists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Society of Feed Technologists (SFT), provides a forum open to those interested in the production and welfare of farmed livestock. The group was multi-disciplinary and included animal nutritionists, feed technologists, recipe formulators, academics, pharmacologists, veterinary surgeons, geneticists, feed mill managers and farm advisers. KW was invited to speak at their 50th Anniversary Celebration to discuss the role of genetics in current developments in pig and poultry production "Genetic developments and their future application to pig and poultry production". The presentation precipitated a wealth of discussions the current and future developments for Europe's poultry production industry. |
| Year(s) Of Engagement Activity | 2007 |
| URL | https://sft.uk.com/events-conferences/past-test-event/ |
| Description | Invited talk University of Guelph, The 'Who ate all the pies gene', University of Guelph, 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the Animal Science department of the University of Guelph |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://animalbiosciences.uoguelph.ca/events/2018/07/who-ate-all-pies-gene-and-its-implications |
| Description | Invited talk at the 17th Intl. Conference on Production Diseases in Farm Animals. Phenotypes and genotypes for Bone Quality, Bern, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The audience was a new one for me and it allowed access to veterinarians and others studying production diseases. The sessions were mixed but the theme of skeletal health and particularly keel bone damage was a theme through the different sessions |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.icpd2019.unibe.ch/ |
| Description | Keynote at Avian Research Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at the Avian Research Symposium (online) in March 2023. Talk entitled: The Avian Genome: the current state of play |
| Year(s) Of Engagement Activity | 2023 |
| Description | New Tools and New Ideas for a Classic Model System |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A talk at the EMBO Workshop 'Limb Development and Regeneration- New Tools for a Classic Model System' to 100+ international scientists |
| Year(s) Of Engagement Activity | 2019 |
| Description | News artcile on BBC news website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release was developed relating to our publication in BMC Biotechnology describing production and purification of bioactive proteins in the eggs of transgenic hens. This article was written by Pallab Ghosh of BBC and attracted a lot of attention and other news articles across the world. Contacts have been received from interested businesses. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/news/uk-scotland-47022070 |
| Description | Oral presentation at the XVIth Avian Immunology Research Group at the university of Delaware, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation by ECR Dr Kate Sutton at the AIRG, entitled CSF2 & IL4- & CSF2-dependent Chicken Bone Marrow Cultures Represent Cells of the Macrophages Lineage |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ud-pcs.idloom.events/2022-airg-conference |
| Description | Oral presentation at the XVIth Avian Immunology Research Group at the university of Delaware, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation by ECR Dr Kate Sutton at the AIRG, presentation entitled The Conservation of Mammalian M cell Gene Signatures in Chicken CSF1R-transgene Antigen-Sampling M cells |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ud-pcs.idloom.events/2022-airg-conference |
| Description | Oral presentation at the XVIth Avian Immunology Research Group at the university of Delaware, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation by ECR Dr Kate Sutton at the AIRG, entitled Differential Innate Immune Responses of Chicken 3D and 2D Enteroids to Salmonella Typhimurium Infection |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ud-pcs.idloom.events/2022-airg-conference |
| Description | Poster Presentation by K Sutton at the British Society for Immunology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation by ECR Dr Kate Sutton at the BSI in Liverpool presenting a poster entitled: Differential Innate Immune Responses of Chicken 3D and 2D Enteroids to Salmonella Typhimurium Infection. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/thome.csp?pageID=7351&eventID=10&CSPCHD=0000010000001vS... |
| Description | Poster presentation by K Sutton at the British Society for Immunology Congress 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation by ECR Dr Kate Sutton at the annual meeting of the BSI in Liverpool, entitled: The Conservation of Mammalian M cell Gene Signatures in Chicken CSF1R-transgene Antigen-Sampling M cells |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/thome.csp?pageID=7351&eventID=10&CSPCHD=0000010000001vS... |
| Description | Presentation to Gates Foundation and DfID |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Mick Watson presented work on African farm animal genomics and data science to attendees from the Bill and Melinda Gates Foundation (BMGF) and the department for international development (DfID) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Press coverage of new NC3R grant to biobank chicken breeds: poultry world |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Coverage of our awarded grant to reduce numbers of chickens used in research |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.poultryworld.net/poultry/chicken-biobank-to-cut-numbers-of-birds-for-research/ |
| Description | Press coverage of new bio banking technique Poultry world |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The poultry community (researchers, breeders and commercial companies) were informed of our new bio banking technique through press coverage of our new publication |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.poultryworld.net/poultry/genetics/safeguarding-genetic-diversity-of-indigenous-chickens/ |
| Description | Press coverage: Gene editing to enhance production in developing nations Poultry world |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Gene editing to enhance production in developing nations: magazine coverage of our research in Poultry World Magazine |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.poultryworld.net/Genetics/Articles/2021/2/Gene-editing-to-enhance-production-in-developi... |
| Description | Public lecture entitled Confronting the Microbial Menace in Our Food'. Professor Mark Stevens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The inaugural lecture of Professor Mark Stevens was held on 30 October 2017 on his BBSRC-funded research to identify bacterial and host factors influencing the ability of Salmonella, Campylobacter and E. coli to colonise farm animals and cause disease. It was attended by children from local schools, members of the public, students at The Roslin Institute and wider University of Edinburgh and posted online. |
| Year(s) Of Engagement Activity | 2017,2018 |
| URL | https://media.ed.ac.uk/media/Inaugural+lectureA+Confronting+the+microbial+menace+in+our+food/1_x5k5e... |
| Description | Public lecture on Campylobacter in chickens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public talk on 'Chickens and the enemy within' at The Roslin Institute Open Doors Day in 2012. This highlighted the problem of Campylobacter infections in people, the role of poultry as a reservoir, and research at Roslin to control the problem via genetic selection and vaccination in poultry and to understand the molecular basis of virulence of the organism. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Published article received press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Published article discussed in public online forum |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-39006713 |
| Description | Published article receiving press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press article in the Telegraph describing biobanking of chicken breeds using GM chicken hosts in a positive light |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.telegraph.co.uk/news/2017/02/17/rarechickensbrought-back-brink-extinction-edinburgh-unive... |
| Description | Published article receiving press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press article on gene targeted chicken used to study germ cell development and to develop surrogate host chickens for rare breed conservation |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ft.com/content/10000b26-f52c-11e6-8758-6876151821a6 |
| Description | Radio interview arising from publication |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | I was interviewed following my research paper publication, on the Royal National Institute of Blind People (RNIB) Connect Radio programme. This interview was to raise awareness of the birth defect Coloboma, and to disseminate the successful identification of new coloboma-causing mutations and my research program working towards improving our understanding of the causes of the condition. |
| Year(s) Of Engagement Activity | 2017 |
| Description | STAR Lecture 2019- provided material for lecture/podcast |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Provided video material of developing embryos for the Royal Society Christmas lectures (in Singapore) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.mewatch.sg/en/series/star-lecture-2019/ep1/840029 |
| Description | Talk to Aviagen regarding Embryonic Tempo |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | A talk at Aviagen regarding the detection and selection of pre-hatch traits in chicken breeding strategies |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk to patient group for Primary Ciliay Dyskinesia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | To mark PCD Awareness Day I talked on my models for PCD and the potential for large animal models using genome engineering |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Avian Immunology Research Group (AIRG) 2018 meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation "Identification and characterisation of avian conventional dendritic cells" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Understanding Human Birth Defects in the Genomic Age, Company of Biologists Workshop, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A talk at the Company of Biologists Workshop on 'Understanding Human Birth Defects in the Genomic Age' |
| Year(s) Of Engagement Activity | 2019 |
| Description | Visit by Bill Gates and the Secretary of State for the Department of International Development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Gates and the Secretary of State for the Department of International Development (DfID; Rt Hon Penny Mordaunt) visited The Roslin Institute on 26 January 2018. This involved separate sessions with the Gates Foundation and DfID to learn about the research undertaken by the Centre for Tropical Livestock Genetics & Health (CTLGH), in which the Roslin Institute is a major partner and researchers in the Institute Strategic Programmes are heavily involved. DfID announced £4m of funding for the CTLGH, adding to £10m already received from the Gates Foundation. In the presence of the Principal of the University of Edinburgh, Bill Gates and the Rt Hon Penny Mordaunt formally opened the Global Academy for Agriculture & Food Security which will provide undergraduate and postgraduate training in sustainable agriculture. The event took place in the new Campus Innovation Building (which received BBSRC strategic funding). The University of Edinburgh press office tracked the following activity related to the visit, in which many participants in the ISPs were involved: • 109 individual articles and broadcast pieces that mentioned the University with regards to the visit, with an estimated potential reach of more than 7 million people. • Of these, more than half of the coverage mentioned one of more of the Global Academy of Agriculture & Food Security, the Centre for Tropical Livestock Genetics & Health, SEBI, the Royal (Dick) School of Veterinary Studies, Roslin or the Easter Bush Campus in addition to name checking the University. • In addition to the UK, we also attracted press coverage in the USA, France, New Zealand, China, Zimbabwe, South Africa, Botswana, Taiwan and Egypt. • Across social media, we reached more than 1.4 million people with 14k+ engagements (likes, shares, retweets etc). Of these, 99.8% were positive. • The Facebook Live streaming alone reached more than 100k people. More than 18k people have watched the video. • Our news videos have garnered more than 35k views across platforms. • We tracked a spike in traffic to the Global Academy website on the day of the visit - 1405 visits (11 times the average for the previous month). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit of Bill Gates |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Bill Gates and Penny Mordaunt visited the Easter Bush campus to open the new Global Academy for Food Security. At that event, I presented our work on african farm animal genomes and programme 5 of the CTLGH. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.gov.uk/government/speeches/penny-mordaunt-speech-at-edinburgh-university-with-bill-gates |
| Description | XIXth European Symposium on the Quality of Eggs and Egg products, 7-9 September, Krakow, Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation to industry and scientist interested in egg quality Does oviposition interval affect the deposition of cuticle on the eggshell? |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://eggmeat2023.com/ |
| Description | editorial on uses of GM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Presented to reporters at AAAS, Boston USA |
| Year(s) Of Engagement Activity | 2017 |