Modulation of the gut microbes to promote health throughout life
Lead Research Organisation:
QUADRAM INSTITUTE BIOSCIENCE
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This theme focuses on the translational aspect of the Gut Microbes and Health programme, which will pursue ongoing applied work within the programme but will also identify additional targets based on the output of basic research outlined in themes 1 and 2, to strengthen and further develop strategies to promote health throughout life. Specifically, these will focus on developing bifidobacterial-based probiotics for infant supplements as well as lactic acid bacteria for animal feed to reduce the pathogen load in the food chain to reduce the incidents of food poisoning in humans.
Gut commensal organisms capable of efficient expression of specific enzyme and antimicrobial peptides to inhibit pathogens such as C. difficile, which affects the elderly, will be developed and tested. We also propose to identify carbohydrate-based mucosal barrier protectors as well as gut commensals and their products as therapeutics and for development of vaccines to promote gut health. We will explore strategies for modulation of the structure and function of the gut microbiome, including the application of faecal microbiota transplant, phage therapy and exploitation of the gut commensal eukaryotes (yeast and fungi) for restoration of gut microbiota homeostasis. We will utilise in-house facilities of tissue and organ cultures, in vitro colon models, animal models (including germ free mice) as well as human intervention studies to conduct proof-of-concept studies and demonstrate efficacy of the strategies developed.
Gut commensal organisms capable of efficient expression of specific enzyme and antimicrobial peptides to inhibit pathogens such as C. difficile, which affects the elderly, will be developed and tested. We also propose to identify carbohydrate-based mucosal barrier protectors as well as gut commensals and their products as therapeutics and for development of vaccines to promote gut health. We will explore strategies for modulation of the structure and function of the gut microbiome, including the application of faecal microbiota transplant, phage therapy and exploitation of the gut commensal eukaryotes (yeast and fungi) for restoration of gut microbiota homeostasis. We will utilise in-house facilities of tissue and organ cultures, in vitro colon models, animal models (including germ free mice) as well as human intervention studies to conduct proof-of-concept studies and demonstrate efficacy of the strategies developed.
Planned Impact
unavailable
Organisations
- QUADRAM INSTITUTE BIOSCIENCE (Lead Research Organisation)
- NutriLeads (Collaboration)
- St Mark's Academic Institute (Collaboration)
- University of Oxford (Collaboration)
- Clasado BioSciences (Collaboration)
- National Agri-Food Biotechnology Institute (Collaboration)
- UNIVERSITY OF KENT (Collaboration)
- Utrecht University (Collaboration)
- Korea National University of Transportation (Collaboration)
Publications
A James S
(2020)
Preterm Infants Harbour a Rapidly Changing Mycobiota That Includes Candida Pathobionts.
in Journal of fungi (Basel, Switzerland)
Acuna-Gonzalez A
(2023)
Bifidobacterium bacteraemia is rare with routine probiotics use in preterm infants: A further case report with literature review.
in Anaerobe
Adriaenssens EM
(2021)
Tracing the fate of wastewater viruses reveals catchment-scale virome diversity and connectivity.
in Water research
Adriaenssens EM
(2023)
Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification.
in Nature biotechnology
Adriaenssens EM
(2021)
Phage Diversity in the Human Gut Microbiome: a Taxonomist's Perspective.
in mSystems
Alba C
(2024)
Characterization of a Ligilactobacillus salivarius Strain Isolated from a Cheese Seal Which Was Last Used in 1936.
in Foods (Basel, Switzerland)
Alcon-Giner C
(2020)
Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.
in Cell reports. Medicine
| Title | Bifidobacterium bronze and perfume sculpture - Wellcome Collection (Being Human) |
| Description | Food historian and artist Tasha Marks of AVM Curiosities has developed a playful bronze and perfume sculpture which suggests the smell of breast milk and celebrates the microbiome and our symbiotic relationship with bacteria. This was in collaboration with Dr Lindsay J Hall |
| Type Of Art | Artwork |
| Year Produced | 2019 |
| Impact | This has enhanced the public's knowledge on the links between certain microbiota members i.e. Bifidobacterium and early life diet - breast milk. |
| URL | https://wellcomecollection.org/pages/XW5QMBEAACUAELBV |
| Title | Guardians of the Gut Exhibit |
| Description | "Guardians of the Gut": 6-meter-long, 2-meter-high gut, with internal game stations which allowed visitors to interact with their 'microbes |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2018 |
| Impact | This exhbit has been shown at the Royal Society Summer Exhibition and Norwich Science Festivals 2018 |
| Description | • We have developed new rapid sequencing approaches/software (MinION) that allows metagenomic analysis of preterm infant-associated multi-drug resistance bacteria in parallel with new lab-based methodologies (e.g. selective culturing of early-life microbiota from infant faecal samples, phenotypic diet-Bifidobacterium assays and in vivo models), short-and long-read protocols for optimal early-life microbiome sequencing, and crucial downstream tools for robust bioinformatics analysis (e.g. automated pipelines). • We have established an advanced model human colon system that enables experimental evaluation of competitive exclusion with pre, pro and postbiotics and mechanistic evaluation of diet microbiome interactions. • We have established advanced organ-on-chip technology at QIB, particularly gut organoids-on-chip models and during COVID-19, lung-on-chips were established; both alveolar- and airway-on-chips; these have been used to test Sars-Cov-2 (provided by UKHSA) in CL3 Lab at QIB. • Ageing is characterized by declining cell, tissue, and organ function and increasing susceptibility to chronic and debilitating diseases. Particularly vulnerable are tissues of the central nervous system (CNS) and the eye, which have high sensitivity to metabolic dysregulation, and the gastrointestinal (GI) epithelial barrier. These changes in the CNS and GIT are paralleled by changes in the community structure and function of the intestinal microbiota. Our FMT studies in a mouse model of ageing showed that the transfer of aged donor microbiota into young mice accelerated age-associated central nervous system (CNS) inflammation, retinal inflammation and cytokine signalling, and promoted loss a of key functional protein in the eye, effects coincident with increased intestinal barrier permeability. This provides direct evidence for the ageing gut microbiota driving detrimental changes in the gut-brain and gut-retina axes suggesting that microbial modulation could be of therapeutic benefit in preventing inflammation-related tissue decline in later life. • Our research developing unique mouse models to study autophagy 'in vivo' demonstrates that a domain within autophagy protein ATG16L1 that carries risk allele for Crohn's disease protects mice against cognitive decline, acute pancreatitis and cytokine storm associated with lethal influenza virus infection. This shows that a mutation commonly associated with inflammation of the gut, also affects inflammation in distal organs including the brain. These models will be used to study the effect of the gut microbiota and diet on cognitive decline during ageing. • We performed a detailed meta analysis of the microbiome of Parkinson's disease patients and found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities. • We developed diagnostic assays for detection of Sars-cov-2 in human stool samples • We applied machine learning to metagenomic of the gut microbiome of Parkinson's disease patients and discovered enhanced metabolic pathways associated with metabolism of xenobiotic compounds • We have established a broad and well-characterised phage collection for human gut associated bacteria that can become pathogenic, such as Klebsiella sp. and E.coli. • We developed better sequencing workflows using long and short-read sequencing to improve phage genomics. |
| Exploitation Route | The findings described can be utilised by others in the field diet gut microbiome and health. the results obtained will be taken forward for translational application for development of new diagnostics and therapeutics. |
| Sectors | Agriculture Food and Drink Creative Economy Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | We have increased fundamental understanding and progressed translation of new products, diagnostics and therapeutics with significant potential health impact nationally and internationally. Examples indicative of our impact pipelines include: Faecal Microbiota Transplants (FMT) and bacteriotherapy for persistent Clostridium difficile infections enabling patients to return to a normal quality of life; understanding the link between antibiotic use and rheumatoid arthritis has informed the advice given to patients at high risk; using commercially-produced human milk oligosaccharides as therapeutics for conditions linked to gut inflammation; biomarkers of health and diseases (e.g. fucosidase for the diagnosis of Maturity Onset Diabetes of the Young (MODY) and certain cancers); a new method for accelerating infection diagnosis in new-borns is under development and will inform treatment choices; biocontrol of pathogens such as C. perfringens and Campylobacter jejuni are under evaluation; revealing the role of molecular regulators in chronic liver disease; and we confirmed that changes in the gut microbiome are connected with Parkinson's disease and that an ageing gut microbiota drives detrimental changes in the gut-brain and gut-retina axes. Our work attracted industry interest and contracts managed by QIB-Extra. Our work has also led to new avenue of research to explore the potential link between specific groups of bacteria and Parkinson's disease and additional funding from charity associated with Parkinson's disease. We have contributed to the UK parliamentary inquiry by the Science, Technology and Innovation Committee into the use of bacteriophages to combat antimicrobial resistance. Our written evidence was cited multiple times in the parliamentary report and contributed to the recommendations made. |
| First Year Of Impact | 2023 |
| Sector | Agriculture, Food and Drink,Education,Healthcare |
| Impact Types | Cultural |
| Description | Membership of R&D Executive Committee influencing educational and research policy updated annually |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Description | Written response to government inquiry on bacteriophages |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://committees.parliament.uk/writtenevidence/114423/pdf/ |
| Description | An OMV-based SARS-CoV-2 (COVID-19) mucosal vaccine technology platform |
| Amount | £10,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 04/2021 |
| Description | BBSRC IAA The Quadram Institute |
| Amount | £300,000 (GBP) |
| Funding ID | BB/S506679/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2022 |
| Description | BBSRC IPA International Partnering Award |
| Amount | £30,582 (GBP) |
| Funding ID | BB/T020008/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2026 |
| Description | Bacterioph00ages for gut health |
| Amount | £614,467 (GBP) |
| Funding ID | BB/W015706/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 10/2025 |
| Description | Bacteriophages in the ageing gut as targeted therapeutics |
| Amount | £115,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2027 |
| Description | CARDING_Q20CASE: The gut microbiome and inflammaging |
| Amount | £150,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2024 |
| Description | CLRN Flexibility & Sustainability Research Funding |
| Amount | £55,975 (GBP) |
| Funding ID | RDFSF025 |
| Organisation | London North West Healthcare NHS Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 07/2019 |
| Description | CLRN Flexibility and Sustainability Research Funding |
| Amount | £53,698 (GBP) |
| Funding ID | RDFSF024 |
| Organisation | London North West Healthcare NHS Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 07/2018 |
| Description | Canada Partnering Award: A one health approach to understanding and using bacteriophages in the control of enteric pathogens |
| Amount | £33,838 (GBP) |
| Funding ID | BB/V018086/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 12/2023 |
| Description | Clinical seedcorn |
| Amount | £40,000 (GBP) |
| Organisation | Quadram Institute Bioscience |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 12/2024 |
| Description | Development of a Bacteriophage Based Solution for the Treatment of Implant Related Infections |
| Amount | £84,208 (GBP) |
| Funding ID | 42897000M |
| Organisation | Norfolk and Norwich University Hospital |
| Sector | Hospitals |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 01/2019 |
| Description | Evaluation of HMOs on gut barrier function |
| Amount | £200,000 (GBP) |
| Organisation | Glycom A/S |
| Sector | Private |
| Country | Denmark |
| Start | 01/2017 |
| End | 07/2019 |
| Description | Fermented seaweed based novel feed additives - SEAFEED |
| Amount | € 490,000 (EUR) |
| Organisation | European Institute of Innovation and Technology (EIT) |
| Sector | Public |
| Country | Hungary |
| Start | 01/2019 |
| End | 01/2020 |
| Description | HPRU GI infection |
| Amount | £5,600,000 (GBP) |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2025 |
| End | 03/2030 |
| Description | Immune Response to Q-fever |
| Amount | £99,990 (GBP) |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2021 |
| Description | Integrated Models of the Human Gut- Capital Grant Award for 2021/22 Investment Gateway Panel Business Cases. |
| Amount | £1,152,556 (GBP) |
| Organisation | Quadram Institute Bioscience |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 03/2022 |
| Description | International Exchanges 2019 Cost Share (NSFC) - IEC\NSFC\191523 |
| Amount | £12,000 (GBP) |
| Organisation | Quadram Institute Bioscience |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2023 |
| Description | KEC PoC grant New human colon-intestine-chip model |
| Amount | £15,000 (GBP) |
| Organisation | Quadram Institute Bioscience |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2021 |
| End | 03/2022 |
| Description | LINK funding |
| Amount | £250,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2024 |
| End | 08/2025 |
| Description | MMB DTP |
| Amount | £80,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | MMB DTP |
| Amount | £80,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | NRP DTP studentship |
| Amount | £10,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2024 |
| Description | NRPDTP |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | NRPDTP CASE |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2028 |
| Description | NRPDTP Studentship Bacteriophages as key players in bacterial adaptation to the human gut |
| Amount | £105,000 (GBP) |
| Funding ID | 2748665 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | NRPDTP VitB12 |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 06/2024 |
| Description | NRPDTPbacteriocin |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | New antimicrobials to target gut pathogens |
| Amount | £20,000 (GBP) |
| Funding ID | 2116844 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2023 |
| Description | Norwich Research Park Bioscience Doctoral Training Partnership |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2019 |
| Description | Norwich Research Park Bioscience Doctoral Training Partnership |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 10/2022 |
| Description | Nutrileads project |
| Amount | £33,350 (GBP) |
| Organisation | NutriLeads |
| Sector | Private |
| Country | Netherlands |
| Start | 03/2020 |
| End | 08/2020 |
| Description | Phages in the infant gut: good, bad or neutral? |
| Amount | £105,000 (GBP) |
| Funding ID | 2444856 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2024 |
| Description | Potential therapeutic effects of engineered Clostridium STp products on immune activity |
| Amount | £86,600 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2023 |
| Description | RESTORE ME - FMT Clinical Trial |
| Amount | £620,000 (GBP) |
| Organisation | Invest in ME Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 08/2023 |
| Description | Research contract |
| Amount | £99,990 (GBP) |
| Funding ID | 1000137348 |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 02/2021 |
| Description | Reservoirs of mobile antibiotic resistance genes in the gut microbiome of preterm infants |
| Amount | £588,844 (GBP) |
| Funding ID | BB/S017941/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 08/2023 |
| Description | St Marks Foundation Research Grants |
| Amount | £216,138 (GBP) |
| Funding ID | RES209 |
| Organisation | St Marks Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2020 |
| Description | St Marks Hospital Studentship |
| Amount | £20,996 (GBP) |
| Organisation | St. Mark's Hospital Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2022 |
| Description | TROVE Research Project |
| Amount | £12,000 (GBP) |
| Funding ID | RES231 |
| Organisation | St. Mark's Hospital Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 02/2020 |
| Description | Training interdisciplinary glycoscientists to get a molecular- level grip on glycocodes at the human mucosa-microbiota |
| Amount | £466,300 (GBP) |
| Funding ID | 814102 |
| Organisation | European Commission |
| Sector | Public |
| Country | Belgium |
| Start | 01/2019 |
| End | 12/2022 |
| Description | iCASE doctoral training programme |
| Amount | £69,900 (GBP) |
| Funding ID | Enterprise DTP: MRC iCASE Studentship 2019-20 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2023 |
| Title | An optimised protocol for detection of SARS-CoV-2 in stool |
| Description | We describe a sensitive method for detecting SARS-CoV-2 in stool samples. This method can be used to establish the persistence of SARS-CoV-2 in stool and ensure the safety of clinical practices such as faecal microbiota transplant (FMT). |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | none yet |
| Title | Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives. |
| Description | A facile one-pot two-enzyme approach has been established for the synthesis of 2,7-anhydro-sialic acid derivatives including those containing different sialic acid forms such as Neu5Ac and N-glycolylneuraminic acid (Neu5Gc). This synthetic method, which is based on a membrane-enclosed enzymatic synthesis, can be performed on a preparative scale. Using fetuin as a substrate, high-yield and cost-effective production of 2,7-anhydro-Neu5Ac was obtained to high-purity. This method was also applied to the synthesis of 2,7-anhydro-Neu5Gc. The membrane-enclosed multienzyme (MEME) strategy reported here provides an efficient approach to produce a variety of sialic acid derivatives. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The method allowed to produce 2,7-anhydro-sialic acid derivatives (not commercially available) in amount and purity allowing further mechanistic studies and exploring applications in the health sector |
| Title | Additional file 1 of CoronaHiT: high-throughput sequencing of SARS-CoV-2 genomes |
| Description | Additional file 1: Table S1. Barcode sequences. Table S2a. Sample metrics for the Routine dataset. Table S2b. Sample metrics for the Rapid Response dataset. Table S3. The differences between the consensus genomes of each sequencing method, for all samples with differences reported. Table S4. Reagent costs for the three methods when sequencing 96 samples (CoronaHiT-ONT and ARTIC LoCost) or 384 samples (CoronaHiT-Illumina). Table S5. Sample identifiers and accession numbers. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_CoronaHiT_high-throughput_... |
| Title | Additional file 1 of CoronaHiT: high-throughput sequencing of SARS-CoV-2 genomes |
| Description | Additional file 1: Table S1. Barcode sequences. Table S2a. Sample metrics for the Routine dataset. Table S2b. Sample metrics for the Rapid Response dataset. Table S3. The differences between the consensus genomes of each sequencing method, for all samples with differences reported. Table S4. Reagent costs for the three methods when sequencing 96 samples (CoronaHiT-ONT and ARTIC LoCost) or 384 samples (CoronaHiT-Illumina). Table S5. Sample identifiers and accession numbers. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_CoronaHiT_high-throughput_... |
| Title | De novo sequencing of phages T4 and T7 |
| Description | Raw data and assemblies of the de novo sequencing of the "model" phages T4 and T7, performed with Illumina NextSeq 2x150 and Oxford Nanopore, generated for the "Phage Annotation Workshop" held online on November 2021: https://github.com/quadram-institute-bioscience/phage-annotation-workshop/ |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Datasets used as teaching materials and available for any scientist to use. |
| URL | https://zenodo.org/record/5704419 |
| Title | GeneCatalog.faa |
| Description | proteins for chicken gene catalog |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/GeneCatalog_faa/19582717 |
| Title | GeneCatalog.faa |
| Description | proteins for chicken gene catalog |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/GeneCatalog_faa/19582717/1 |
| Title | MOESM1 of Genomic analysis on broiler-associated Clostridium perfringens strains and exploratory caecal microbiome investigation reveals key factors linked to poultry necrotic enteritis |
| Description | Additional file 1. Supplementary tables. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Genomic_analysis_on_broiler-associated_Clostr... |
| Title | MOESM1 of Genomic analysis on broiler-associated Clostridium perfringens strains and exploratory caecal microbiome investigation reveals key factors linked to poultry necrotic enteritis |
| Description | Additional file 1. Supplementary tables. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM1_of_Genomic_analysis_on_broiler-associated_Clostr... |
| Title | Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease. |
| Description | Taxonomic and functional profiles generated and analysed in the publication titled: "Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease." |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | https://zenodo.org/doi/10.5281/zenodo.14261086 |
| Title | PRJNA914245 - Klebsiella Przondovirus sequence data |
| Description | Sequence data for the genomes of 10 newly discovered bacteriophages that infect Klebsiella spp. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Genome data is being used for comparative genomics, taxonomy and identification of antibacterial proteins. |
| URL | https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA914245 |
| Description | Chemical glycobiology |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Contributed to successful multidisciplinary European Training Network Sweetcrosstalk proposal Supervising tow ESRs on the project WP leader |
| Collaborator Contribution | Coordinator of ITN Host of one of my ESRs |
| Impact | Chemistry, Glycobiology, Microbiology |
| Start Year | 2018 |
| Description | Collaboration with professor Amit Rai India |
| Organisation | National Agri-Food Biotechnology Institute |
| Country | India |
| Sector | Public |
| PI Contribution | We hosted the visit of prof Amit Rai to QIB and In March 20204 Arjan Narbad visited NABI-DTP institute and gave a presentation and discussed further collaboration. |
| Collaborator Contribution | Prof Rai visited QIB in February 2024 and this resulted in further planned collaboration grant applications to extend the link between QIB and NABI-DBT institute. Joint experimental work is planned. |
| Impact | Further short term funding to undertake collaboration experimental work via staff exchange from NABI to QIB. |
| Start Year | 2024 |
| Description | Collaboration with professor Gi-Seong Moon |
| Organisation | Korea National University of Transportation |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | We hosted the visit and undertook collaborative experimental worked on fermented foods |
| Collaborator Contribution | Professor Moon visited QIB for six months and undertook experimental work on novel natural antimicrobials to combat Clostidioides difficle. During his stay professor Moon gave presentations and mentored PhD students |
| Impact | Preliminary results that will form basis of a publication |
| Start Year | 2023 |
| Description | Colorectal Cancer Team |
| Organisation | St Mark's Academic Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide immunological research expertise, design of laboratory studies, data analysis and student training and supervision. |
| Collaborator Contribution | Partnership with the St Marks Colorectal Cancer Team is enabling the study of the relationship between obesity, the gut microbiota, muscle function and cancer. |
| Impact | Development of a new ethical committee approval 17/LO/1636. Preliminary evidence suggests that immune cells in the muscles, and fat within the immune cells, together with changes in the microbiota influence colorectal cancer. This approach is likely to contribute to new personalised treatments for cancer. Further plans for a new clinical fellow to take this work forward are in process. |
| Start Year | 2017 |
| Description | Health ingredient company |
| Organisation | NutriLeads |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Test effect of plant-derived polysaccharides on gut barrier function |
| Collaborator Contribution | Provided compounds to be tested Funded project |
| Impact | Report to the company |
| Start Year | 2020 |
| Description | Polyposis Team |
| Organisation | St Mark's Academic Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | St Marks Academic Institute for the Study of Colorectal Diseases is a national and international referral centre for colorectal diseases. Partnering with the Polyposis Team is enabling immune profiling of patients with pre-malignent conditions in relation to the gut microbiota. |
| Collaborator Contribution | Provision of clinical expertise and material |
| Impact | Development of a new Ethical Committee approval - 17/LO/16/36 Changes in immune responses to gut microbiota have been identified in pre-malignant cancer patients with APC gene mutations. We are identifying basic immune parameters that may predispose to the development of malignancy raising the possibility of individualised diagnosis / treatment. |
| Start Year | 2018 |
| Description | Prebiotic SME |
| Organisation | Clasado BioSciences |
| Country | Jersey |
| Sector | Private |
| PI Contribution | Testing of prebiotic compounds on gut microbiota and gut barrier function |
| Collaborator Contribution | Provided study product, human resource, expert knowledge |
| Impact | INFORM grant (BIV) on going |
| Start Year | 2024 |
| Description | Structural biology |
| Organisation | University of Oxford |
| Department | Oxford Hub |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identified and functionally characterised a novel enzyme activity in gut bacteria |
| Collaborator Contribution | Crystallisation of metabolic enzyme involved in carbohydrate utilisation by bacteria |
| Impact | Manuscript in preparation 3D Structure |
| Start Year | 2019 |
| Description | TROVE project |
| Organisation | St Mark's Academic Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide laboratory facilities, immunological expertise to inform experimental design, laboratory training, data analysis and student supervision and training. |
| Collaborator Contribution | Clinical expertise and patient profiling and samples |
| Impact | Participation in the TROVE research project with clinical partners has allowed us to explore the relevance of efferent lymph feeding to the establishment of the microbial fauna in the gut and the resultant immune profiles in response to individual bacteria. Preliminary evidence indicates that profiling may be used in diagnosis and potentially in bacterial treatment with designer probiotics in the future. |
| Start Year | 2018 |
| Description | Vitamin B12 Biology |
| Organisation | University of Kent |
| Country | United Kingdom |
| PI Contribution | Secured a joint PhD studentship and grant |
| Collaborator Contribution | Input into grant applications and supervisory expertise |
| Impact | Secured a joint PhD studentship and grant |
| Start Year | 2019 |
| Title | Medium Production of Bacterial Extracellular Vesicles |
| Description | The present invention relates to a growth medium or media and the use and/or manufacture thereof for the production of bacterial extracellular vesicles. |
| IP Reference | 2102001.1 |
| Protection | Patent application published |
| Year Protection Granted | 2021 |
| Licensed | No |
| Impact | None as yet. Patent filed 12 Feb. 2021 |
| Description | 'Women of the Future' event for school children |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The 'Women of The Future' conference was aimed at year 10 girls to showcase the opportunites for following a career in science. Around 250 yr 10 girls from Norfolk attended talks, demonstraitons and a 'speed dating' event 'Meet a STEMM professional', where the students talked to presenting scientists and STEMM professionals about their career paths and work. Several students demonstrated an interest in following science at University level. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 4th Annual European Microbiome Congress |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Attendance to 4th Annual European Microbiome Congress. This Conference has a high representation from the Industry: Pharmaceutical companies and Biotechnology companies and provided an excellent opportunity to make contact and discuss work relevant to the Institute Strategic Programmes. The PROMOTING WOMEN IN SCIENCE lunch session was inspiring. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Academia-Industry Networking CarboMet event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I co-organised and chaired a two day workshop on 'The Role of Carbohydrates in the Gut Microbiome' June 2018 in Brussels attended by 40 delegates from academia and industry as apart of CarboMet. CarboMet (Metrology of Carbohydrates for European Bioindustries) is a four-year Coordination and Support Action (CSA) funded by Horizon 2020 FET-OPEN. It is an European Network that facilitates engagement between key players and stakeholders of the glycoscience community across Europe to identify the current state of the art and in particular future innovation and technological challenges in carbohydrate metrology. I co-wrote and edited the CarboMet positioning paper on 'The Essential Roles of Carbohydrates in Promoting Gut Microbiota Function Through All Stages of Life' which summarises discussions that took place during the workshop. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://carbomet.eu/news/positioning-paper-on-role-of-carbohydrates-in-gut-microbiota-function/ |
| Description | Annual Aberdeen University Microbiology Schools Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk to approx 150 17-18 year old school children about important of the gut microbiome and also gave a career talk. Feedback received was very positive with students thinking about microbiology as a degree. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Article for the 'Microbiologist' |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Article written for SfAM magazine 'Microbiologist': First Contact: The importance of the early life microbiota |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Radio Leeds (Gayle Lofthouse show). |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Radio Leeds (Gayle Lofthouse show). Interview about You Are What You Eat TV show and also wider questions about diet and the gut microbiota. |
| Year(s) Of Engagement Activity | 2022 |
| Description | BIA Webinar |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Arjan Narbad, Lindsay Hall and Alan Walker gave a live BIA webinar to industry members. the webinar was then published on You tube that everyone can access. The title of the Webinar was Developing, feeding and restoring the human microbiome' where Dr Lindsay Hall explained 'Early Life Microbiota' , Dr Alana Walker presented 'Diet and the gut microbiota' and Professor Arjan Narbad gave a presentation on 'Restoring the gut microbiome using FMT' more than 370 people have now seen the webinar. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=OtcoxvQvG34 |
| Description | BIA Webinar: Developing, feeding and restoring the human microbiome |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | BIA Webinar: Developing, feeding and restoring the human microbiome. In an interactive webinar with questions from industrial representatives. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Bioinformatics workshop at the Evergreen Phage Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 30 postgraduate students and early career researchers attended a workshop on the use of command-line tools in the analysis of virome data, as part of the Evergreen International Phage Biology meeting in Olympia, WA, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | British Science Week activity - Guardians of the Gut |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | We contributed an activity to British Science Week 2021 based on our own Guardians of the Gut. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.britishscienceweek.org/plan-your-activities/activity-packs/ |
| Description | CRUK-led workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | CRUK Tumour explants workshop |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dialogue event with Older People's Community (public) Group about the microbiome and potential idea for future clinical trial |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dialogue with Broadland Older People's Partnership Group about the microbiome and its impact on health and immunity in older age. Discussion of the components of the microbiome and what and how this can be affected - and the implications for other organ systems. Plenty of discussion with many opinions and questions expressed. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dialogue events with Patient Participation Groups (PPGs) about the microbiome and potential idea for future clinical trial |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Seven (separate) dialogue events with Patient Participation Groups (PPG) at GP practices across Norfolk to discuss the microbiome with patients and a potential idea for a future clinical trial. Discussions included: composition of microbiome, importance of gut health and impact on immunity and effect on other organs, FMT, gut-brain link, changes in microbiome throughout the life course, probiotics, prebiotics and superfoods, immunosenescence, antibiotics. Plenty of discussion and debate at each event with opinions often expressed as changing by the end of each dialogue. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Elucidating the role played by the gut microbiota in neurodegenerative diseases - 10th Biomedical Research into ME Colloquium 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented my findings about the gut microbiome in Parkinson's disease at the 10th Biomedical Research into ME Colloquium 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Expert reaction via Science Media Centre |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Expert reaction to study looking at neonatal antibiotics and growth and BMI in children, as published in Nature Communications* via Science Media Centre. Quotes taken up by press associtaion and used in multiple online newspaper articles and print (Mail, Times and Telegraph) |
| Year(s) Of Engagement Activity | 2021 |
| Description | External presentation (London School of Hygiene & Tropical Medicine) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | The purpose of the presentation was to explore ground for scientific collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Guardians of the Gut (Norwich Science Festival) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Guardians of the Gut stand was part of the annual Norwich Science Festival 2018 and is estimated of being visited by over 100 visitors. The main outcome was to be able to engage with the general public and make them aware of the work performed at Quadram Institute Bioscience, and how it could be translated to improving human health |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://norwichsciencefestival.co.uk/events/health-day/ |
| Description | Guardians of the Gut Classroom Pack |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Guardians of the Gut is an exciting new resource for children to learn about the importance of their gut microbes. It is a teacher-led online resource that is freely available. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://guardiansofthegut.org/ |
| Description | IBCarb |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Contributed to the final IBCarb workshop Glycobiotechnology 2018. IBCarb (Glycoscience Tools for Biotechnology and Bioenergy) is a growing network of glycoscientists from academia and industry. IBCarb was one of the Networks in Industrial Biotechnology and Bioenergy funded by the BBSRC. The workshop was very successful and attracted around 150 attendees (international audience from academia and industry) . This was an opportunity to showcase the Glycosciences carried out in the UK and in partnership with industrial/business partners. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://ibcarb.com/events/ |
| Description | Interview for Radio 4 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited interviewee for Radio 4 programme: Inside Health. Numerous followups for further information and also engagement from Industry for new collaborations has resulted from broadcast. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bbc.co.uk/programmes/m000dpky |
| Description | Interview to promote QIB and COPS study on Park Radio Diss |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview to promote QIB and COPS study on Park Radio Diss. I discussed the research done at QIB and the work we are doing to face the COVID pandemic. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Interview with BBC radio Norfolk to promote CoPS study |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with BBC radio Norfolk to promote the work QIB is doing and its involvement in facing the COVID pandemic |
| Year(s) Of Engagement Activity | 2021 |
| Description | Interviewed and quoted in BBC Future article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Was interviewed and quoted in BBC Future article: What we and don't know about gut health |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bbc.com/future/story/20190121-what-we-do-and-dont-know-about-gut-health |
| Description | Invited Lecture - St Mark's Frontiers in Intestinal failure, Royal Society of Medicine, November 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture presented by member of Antigen Presentation Research Group at St Mark's Frontiers in Intestinal failure, Royal Society of Medicine, November 2019. International conference open to clinical staff, researchers and the general public - successfully reaching new/wider audiences. Potential for new research activity. Presenter won John Nichols prize. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of an invited seminar 'Exploiting bacteriophage endolysins to target Clostridia' at the University of East Anglia Molecular Microbiology lecture series to UEA scientists and students, to highlight some of our work on the development of novel antimicrobials to target gut pathogens. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Latitude Music Festival: Exhibited Guardians of the Gut |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We exhibited our Guardians of the Gut Exhibit at Latitude Festival in July 2019 over 3 days to members of the public (over 5000), We also had several specific school visits (~60 children in total). We received excellent feedback and strong engagement and questions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Member of expert working group for design of new permanent exhibit 'Being Human' at the Wellcome collection. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This a large permanent exhibit housed in the Wellcome Collection (London) that was opened in September 2019. Wellcome are collecting feedback on exhibit. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://wellcomecollection.org/pages/XW5QMBEAACUAELBV |
| Description | Microbiology Society 2018 selected talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Dr Zoe Schofield was selected to give an oral short talk talk at the annual Microbiology Society Meeting (Birmingham 2018): Bifidobacterium breve stimulates immune development in germ-free mice |
| Year(s) Of Engagement Activity | 2018 |
| Description | NIHR HPRU annual conference 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This is a yearly conference organised by the representatives of the funding body and the theme leaders. Arjan Narbad (theme leader), Lee Kellingray (Research scientist), and Saskia Neuert (PhD student) attended, with all three giving oral presentations. This allows researchers to share progress, plans, ideas for the future, and to offer help and guidance to one another. This was followed by a discussion with the External Advisory Panel and all researchers to get ideas about how the central project (all themes) can be improved in the future. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://hprugi.nihr.ac.uk/about-us/news/hpru-gi-annual-conference-2018/ |
| Description | Norfolk and Norwich University Hospital Open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Two members of the award (Lee Kellingray (Research scientist) and Saskia Neuert (PhD student)) produced posters and activities as part of an Open Day located at the Norfolk and Norwich University Hospital. It was estimated that approximately 200 people visited this event from the Norfolk region, consisting of the general public, medical practitioners, and patients. This event was reported in the NHS newsletter and the local newspaper. This gave an opportunity for us to showcase the research we are performing as part of this award to explain to the attendees how we are working with the NHS to try and improve hospital services through improvements to diagnostic capability and the use of FMT to improve patient health. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.nnuh.nhs.uk/events/charity-events/2017/03/open-day-and-fete-2017/ |
| Description | Norwich Parkinson's UK branch meeting Presentations and Q&A session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We presented our work regarding the microbiome-gut-brain axis. We discussed our fundings and answered questions from careers and patients. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Norwich Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Members of QIB, including from the Narbad group, were present for the whole day of a week long program. As well as discussions with participants, manning tables and displays, there were also hands-on activities, games, and crafts |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://norwichsciencefestival.co.uk/ |
| Description | Oral presentation at the African Phage Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Africa Phage Forum organised a virtual symposium "African Phage Symposium 2021" for all stakeholders (students, academics and NGOs) on the continent, with invited talks from international stakeholders and academics. I presented a seminar titled "Basics of phage genome annotation & classification - How to get started" which addresses one of the key knowledge gaps for African scientists, sequencing and genomics. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://apf.phage.directory/ |
| Description | Oral presentation at the Norwich Research Park Earth & Life Systems Alliance (ELSA) workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Virtual workshop showcasing research done at the Norwich Research Park to improve knowledge exchange across the park and engage postgraduate students. |
| Year(s) Of Engagement Activity | 2020 |
| Description | PHAVES: Ask Me Anything |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Virtual Debate in the Ask Me Anything format organised by the international non-profit organisation Phage Directory in order to promote phage research and international collaboration across the globe. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Patient group workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The research area and potential future directions were presented to the local hospital patient forum, in order to involve patients and public in the design of the research for a future grant proposal. There was a lot of feedback and suggestions from patients which were incorporated into the proposal, and volunteers for a future steering committee were recruited. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Podcast for Economist |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast with the 'Economist' about the gut microbiome and celiac disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | Policy publication by Microbiology Society |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Contributed to the publication of the Policy document by The Microbiology society. The aim was to To help the microbiology community to consider how it might best take advantage of the opportunities stemming from microbiome research. but at the same time the document woul dbe useful to the wider audience. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://microbiologysociety.org/policy/microbiome-policy-project/unlocking-the-microbiome-report.htm... |
| Description | Populating preterms with probiotics - Clasado online seminar day (QIB hosted event - virtual) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online workshop and talks about the gut microbiome and diet - for healthcare professionals |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation to PHE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Oral presentation given to a mixture of scientists and Industry/Government employees, followed by two meetings discussing a collaboration for the near future |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I was involved in a public debate at Dragons Hall in Norwich (October 2019) as part of the Norwich Science Festival. There was very strong engagement form the audience with lots of follow up questions and results for further information. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://norwichsciencefestival.co.uk/events/dragon-hall-debates-guts/ |
| Description | Public Dialogue Event on Lifelong Health - gut microbes and how they interact with the food we eat to promote health |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Quadram Institute Bioscience held a public dialogue event at the new Quadram Institute when we were joined by 35 members of the public for an open discussion about gut microbes and how they interact with the food we eat to promote health. Simon Carding and Cat Edwards canvassed the group for their opinions using interactive voting technology and there was plenty of lively discussion. The event was illustrated live by Rebecca Osborne who documented the discussion, including questions and debate, in graphical form. Topics discussed included the microbiome and its role in health and disease, the gut-brain connection, prebiotics and probiotics, faecal microbiota transplantation (FMT), healthy and diverse diets, carbohydrates, glycaemic index and our research to investigate the development of healthier food products and future foods designed to counter health problems such as Type 2 diabetes and cardiovascular disease. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Talk (Richmond Scientific Society) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 'Gut bacteria': how microbes influence our health - talk to Richmond Scientific Society, London. There was very strong engagement form the audience with lots of follow up questions and results for further information. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Radio Interview for BBC Radio Norfolk |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interview about our Guardians of the Gut exhibit and the microbiome - in response to the interview we had additional people visit the exhibit during the science festival |
| Year(s) Of Engagement Activity | 2018 |
| Description | Save Money: Good Health ITV 1 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussed the role of the gut microbiota on health and associated 'products' on the market including self-testing kits with Sian Williams (August 2019). |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.itv.com/presscentre/ep4week35/save-money-good-health |
| Description | Stand at Norwich Science Festival: Bacteriophages, can viruses be good? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stand at the Norwich Science Festival where school aged children could do a craft activity to learn about bacteriophages, which are good viruses. Excellent engagement and feedback with children and parents from across East Anglia, estimated 200 children attended the stand. |
| Year(s) Of Engagement Activity | 2021 |
| Description | TV interview - BBC Look East |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | TV interview on BBC Look East about our Guardians of the Gut exhibition - people specifically attended the exhibit after they had watch the interview. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Human Microbiome MOOC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Learn how a healthy microbiome can combat disease Contributed to new MOOK: The Human Microbiome. The microbiome - the microbes that live within the human body - can have a huge impact on human health. As such, it's vital to understand the complexity of the microbiome, and how it can impact on disease and wellbeing. On this course, you'll go on a fascinating journey into the human body - down to the gut - where the ecology and roles of the human microbiome will be narrated. You'll explore how your microbiome changes throughout your life, reflect on the role of food in its modulation, and explain the functions the microbiome has in the gastrointestinal tract in daily life. Over 4000 people registered and completed 3 week course. There was lots of engagement via the FutureLearn MOOK platform. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.futurelearn.com/courses/the-human-microbiome/1 |
| Description | Workshop presentation - Microbiome as medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | An oral presentation for a BBSRC cross-institute microbiome workshop, looking to foster ideas and collaborations which could lead to novel therapeutics to treat or prevent gastrointestinal disorders/side effects. Discussions were positive and many delegates agreed that this area of research holds promise for future applications in human health |
| Year(s) Of Engagement Activity | 2019 |
| Description | World Microbiome Day Podcast |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | World Microbiome Day Podcast where we described the work QIB is doing and how the microbiome is important for our health. We discuss also the COVID pandemic and what we are doing to face this challange. |
| Year(s) Of Engagement Activity | 2021 |
| Description | World Microbiome Day Radio Marathon - Promoting the work of the Quadram |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | World Microbiome Day Radio Marathon - Promoting the work of the Quadram. The activities within that institute were described together with updates on the COVID19 situation and the work the institute is doing to face this global challenge. >21h combined airtime, Total Items of Coverage: 140, Total Listener Reach: 42,852,000 |
| Year(s) Of Engagement Activity | 2021 |
| Description | You Are What You Eat (Channel 5 - 6 episodes across series running Jan-Feb 2022) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | You Are What You Eat (Channel 5 - 6 episodes across series running Jan-Feb 2022). I was an the microbiome expert for the TV series. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.channel5.com/show/you-are-what-you-eat |
| Description | oral presentation in Computational Biology workshop at the Keystone Symposium on the Global Virome in Health and Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented my work on bacteriophage taxonomy in the context of identifying bacteriophages in microbiome data to a group of experts in viromics. The audience agreed with my assessments and have indicated they will change their practices. |
| Year(s) Of Engagement Activity | 2020 |
| Description | workshop on Fermented foods |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A workshop was organised with research teams of Prof Dae-Kyung Kang of Dankook University and team members of Professor Gi-Seong Moon from Korea National University of Transportation and with Professor Arjan Narbad from Quadram Institute Bioscience The purpose of the meeting was to report on the rcent output of research on fermented foods in the three research team. Additionally to identify specific areas for further collaboration and identify student and postdoc exchange visits. |
| Year(s) Of Engagement Activity | 2024 |