Virology and vaccinology of negative-strand RNA viruses

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

This project is the leadership, direction and management of the work of a group of PhD students and other science staff, primarily externally funded. The work of the group can be divided into two major parts: (i) the understanding of the basic molecular virology of specific viruses that cause livestock disease, the way the viruses replicate, their dependency on specific host proteins and the mechanisms employed by these viruses to counteract host innate immune responses; (ii) the creation of improved vaccines and tests for diseases of economic importance, in collaboration with institute immunologists and the reference laboratories in the Epidemiology division. The aims of the project are an improved understanding of the mechanisms by which different groups of viruses interact with the host, both at the cell and organism level, and how this may govern pathogenicity and host specificity, and the practical application of molecular biology techniques to the creation or improvement of vaccines against diseases caused by viruses in these groups.
My work is to (a) teach PhD students and direct them in projects that ontribute to these aims, as well as examining and tutoring the students of other supervisors in the institute; (b) develop grant applications for funding that will support the project aims, and then direct the staff funded by those grants; (c) work with other senior staff to manage the laboratory spaces and codes of practice to ensure adequate and compliant working environment for the research to be carried out by the staff and students in the group.

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