Role of SOCS2 in the growth retardation of chronic inflammatory disease

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

This project will examine the cellular and molecular mechanisms through which SOCS2 (suppressor of cytokine signalling 2) mediates bone growth and development. SOCS2 has primarily been associated with the negative regulation of growth hormone (GH) and insulin-like growth factor-1 (IGF-I) signalling, as seen by the high growth phenotype of mice lacking SOCS2. Studies investigating the regulatory mechanisms through which SOCS2 controls chondrocyte (cartilage cell) growth through both GH and IGF-I receptor signaling will form the basis of this project.

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