Induced Atropisomerism / Applications in Asymmetric Organocatalysis
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Chemistry
Abstract
One of the great challenges in synthetic chemistry is to develop small-molecule catalysts that can exert high levels of control the stereochemical course of bond-forming processes. In this project we propose to undertake an ambitious programme of study designed to probe whether conformationally dynamic biphenyls can be combined with simple chiral amines to generate a diverse array of organic catalysts for asymmetric synthesis. As part of this study we plan to investigate application of these catalysts in a range of important carbon-carbon and carbon-oxygen bond forming processes. This project will involve a combination of traditional organic synthesis, computational chemistry and robotic synthesis/screening, and we believe that our established expertise in these areas will ensure a high degree of success.
Organisations
People |
ORCID iD |
Barry Lygo (Principal Investigator) |
Publications
Lygo B
(2011)
Highly enantioselective aldol reactions using a tropos dibenz[c,e]azepine organocatalyst
in Tetrahedron
Lygo B
(2009)
Co-catalyst enhancement of enantioselective PTC Michael additions involving glycine imines
in Tetrahedron Letters
Lygo B
(2012)
Synthesis and evaluation of atropos dihydro-5H-dibenzazepinium halide PTCs derived from a-methylbenzylamine.
in Organic & biomolecular chemistry