FLIC - Functional Ligands for Imaging in Cancer
Lead Research Organisation:
Durham University
Department Name: Chemistry
Abstract
Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are two essential imaging methods whose clinical application in cancer research is well established. Recent advances in clinical instrumentation have resulted in equipment with improved resolution and sensitivity. However, current contrast or imaging agents for use in MRI and PET are not as effective for the 21st century instrumentation now being deployed. The design, synthesis and validation of improved, new functional imaging probes is urgently needed. To develop such probes for cancer a multidisciplinary team is required with expertise in synthetic chemistry and radiochemistry, pre-clinical and clinical imaging sciences, and cancer drug development, working in harmony with the needs and aspirations of cancer biology. No single grouping in the UK can currently offer this range of expertise, and therefore to make progress in this important area the formation of a multi-centre collaborative grouping is essential. The proposed FLIC platform grant will establish a collaborative team with strengths in chemistry, cancer imaging and drug development, and in so doing create a chemistry-life science interface that will address a key need in personalised medicine, producing new chemical entities with genuine utility for healthcare and amenable to commercial exploitation.
Organisations
People |
ORCID iD |
David Parker (Principal Investigator) |
Publications
Chalmers K
(2009)
Design Principles and Theory of Paramagnetic Fluorine-Labelled Lanthanide Complexes as Probes for 19 F Magnetic Resonance: A Proof-of-Concept Study
in Chemistry - A European Journal
Chalmers KH
(2011)
Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
in Dalton transactions (Cambridge, England : 2003)
Chalmers KH
(2011)
Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
in Dalton transactions (Cambridge, England : 2003)
Elemento E
(2009)
Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives
in Organic & Biomolecular Chemistry
Neil ER
(2014)
Synthesis, stereocontrol and structural studies of highly luminescent chiral tris-amidepyridyl-triazacyclononane lanthanide complexes.
in Dalton transactions (Cambridge, England : 2003)
Description | How to make probes for use as contrast agents in MRI more effective at clinically relevant fields. |
Exploitation Route | In developing new probes for MRI |
Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Cancer Research Campaign |
Amount | £427,683 (GBP) |
Funding ID | Progamme grant |
Organisation | Cancer Research Campaign |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Cancer Research Campaign |
Amount | £427,683 (GBP) |
Funding ID | Progamme grant |
Organisation | Cancer Research Campaign |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2008 |
End | 12/2013 |