Stimuli-responsive supramolecular polymers in water
Lead Research Organisation:
University of Cambridge
Department Name: Chemistry
Abstract
In summary, we propose the development of a new class of stimuli-responsive, water soluble supramolecular materials including homopolymers, block copolymers, branched polymers and network structures. These materials architectures will be constructed by bringing together polymer building blocks (polymer chains) with specially designed chemical motifs (guest molecules) attached in specific locations (end-groups) on each chain. A unique barrel-shaped host molecule will then be used to spontaneously join together (self-assemble) the polymer building blocks through host-guest recognition chemistry. As the polymeric building blocks will only be held together through a non-covalent (dynamic) linkage, the material architectures will be reversible and switchable, and we hope to develop ways to control them via external stimuli such as electric field, pH, and/or temperature.Currently, very few examples of synthetic stimuli-sensitive, self-assembling supramolecular polymers exist, and the ability to manipulate such systems in an aqueous environment will represent a significant advance in polymer and materials chemistry. The ability to modulate between linear, branched and network-type structures as a function of an external stimulus would be of great utility in a wide variety of applications requiring dynamic control. For example, as these self-assembled systems should be held together quite strongly in water, the research may provide far-reaching implications towards constructing a variety of new synthetic polymer-bio conjugates with applications in drug delivery and medical diagnostics. Furthermore, the different solution properties arising from the switching between a homo-polymer and a block copolymer in the presence of an oxidant or reductant can be coupled to yield a sensor.The proposed research is relevant to a broad section of the polymer and potentially the pharmaceutical industries as it combines fundamental research of self-assembled systems in an aqueous environment. Opening the field of synthetic supramolecular polymers to water-based systems would represent a paradigm shift in current research efforts. Gaining a better understanding of the basic concepts of self-assembly in water should help to bridge the gap between synthetic polymer chemists and biological researchers, thus providing for more immediate combined efforts in drug delivery, diagnostics and sensing between the two communities.
Organisations
People |
ORCID iD |
Oren A. Scherman (Principal Investigator) |
Publications
Appel E
(2012)
Polymer Science: A Comprehensive Reference
Appel E
(2012)
Metastable single-chain polymer nanoparticles prepared by dynamic cross-linking with nor-seco-cucurbit[10]uril
in Chemical Science
Appel E
(2011)
High molecular weight polyacrylamides by atom transfer radical polymerization: Enabling advancements in water-based applications
in Journal of Polymer Science Part A: Polymer Chemistry
Appel EA
(2012)
Formation of single-chain polymer nanoparticles in water through host-guest interactions.
in Angewandte Chemie (International ed. in English)
Appel EA
(2014)
Gluing gels: A nanoparticle solution.
in Nature materials
Appel EA
(2012)
Sustained release of proteins from high water content supramolecular polymer hydrogels.
in Biomaterials
Appel EA
(2010)
Supramolecular cross-linked networks via host-guest complexation with cucurbit[8]uril.
in Journal of the American Chemical Society
Appel EA
(2012)
Supramolecular polymeric hydrogels.
in Chemical Society reviews
Appel EA
(2012)
Ultrahigh-water-content supramolecular hydrogels exhibiting multistimuli responsiveness.
in Journal of the American Chemical Society
Appel EA
(2014)
Activation energies control the macroscopic properties of physically cross-linked materials.
in Angewandte Chemie (International ed. in English)
Description | We discovered how to exploit multiple non-covalent interactions in concert to bring together polymer chains into multi block copolymers as well as into networks and gels that are dynamic and reversible. |
Exploitation Route | Our findings have started a new area of supramolecular polymers held together with host-guest interactions in aqueous media. Many other research groups around the world are now utilising these concepts. There are also a number of industrial areas of interest ranging from pharma, formulations, general chemical and plastics where the fundamental research may very well have direct application. |
Sectors | Aerospace, Defence and Marine,Agriculture, Food and Drink,Chemicals,Construction,Electronics,Energy,Healthcare,Manufacturing, including Industrial Biotechology,Culture, Heritage, Museums and Collections,Pharmaceuticals and Medical Biotechnology,Retail,Transport,Other |
Description | The findings from our research has led to a completely new area of supramolecular polymers assembled through host-guest interactions in aqueous media. In addition to numerous academic outputs, the research has also led to the formation of a spin-out company, aqdot. Additionally, we have introduced a new consolidant for conservation of water-logged wooden artefacts based on this research. |
First Year Of Impact | 2011 |
Sector | Chemicals,Education,Culture, Heritage, Museums and Collections,Other |
Impact Types | Cultural,Societal,Economic |
Description | Atomic Weapons Establishment (AWE) PhD studentship 1 |
Amount | £130,000 (GBP) |
Organisation | Atomic Weapons Establishment |
Sector | Private |
Country | United Kingdom |
Start | 10/2006 |
End | 09/2010 |
Description | Atomic Weapons Establishment (AWE) PhD studentship 2 (CASE top-up) |
Amount | £30,000 (GBP) |
Organisation | Atomic Weapons Establishment |
Sector | Private |
Country | United Kingdom |
Start | 10/2007 |
End | 09/2011 |
Description | Atomic Weapons Establishment (AWE) PhD studentship 3 |
Amount | £63,000 (GBP) |
Organisation | Atomic Weapons Establishment |
Sector | Private |
Country | United Kingdom |
Start | 02/2010 |
End | 04/2012 |
Description | BP PhD Studentship |
Amount | £246,125 (GBP) |
Organisation | BP (British Petroleum) |
Sector | Private |
Country | United Kingdom |
Start | 10/2011 |
End | 09/2015 |
Description | EPSRC Case for New Academics PhD studentship |
Amount | £98,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2007 |
End | 09/2011 |
Description | EPSRC First Grant |
Amount | £614,694 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2008 |
End | 09/2012 |
Description | EPSRC Pathways to Impact Award |
Amount | £56,385 (GBP) |
Organisation | University of Cambridge |
Department | School of the Physical Sciences |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2011 |
End | 05/2011 |
Description | ERC Proof of Concept Grant |
Amount | € 150,000 (EUR) |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 01/2012 |
End | 03/2013 |
Description | ERC Starting Investigator Grant (ASPiRe) |
Amount | € 1,700,000 (EUR) |
Funding ID | 240629 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 11/2009 |
End | 10/2015 |
Description | IAA Follow on Fund (Abo-Hamed) |
Amount | £124,396 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2015 |
Description | Isaac Newton Trust |
Amount | £50,450 (GBP) |
Organisation | University of Cambridge |
Department | Isaac Newton Trust |
Sector | Academic/University |
Country | United Kingdom |
Start | 10/2007 |
End | 09/2010 |
Description | Isaac Newton Trust (w/ Abell) |
Amount | £51,182 (GBP) |
Organisation | University of Cambridge |
Department | Isaac Newton Trust |
Sector | Academic/University |
Country | United Kingdom |
Start | 04/2013 |
End | 03/2014 |
Description | Leverhulme Visiting Professorship (Nau) |
Amount | £22,200 (GBP) |
Organisation | The Leverhulme Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2010 |
End | 09/2010 |
Description | Marie Curie ITN (Hierarchical Self Assembly of Polymeric Soft system (SASSYPOL)) |
Amount | £3,592,910 (GBP) |
Organisation | Marie Sklodowska-Curie Actions |
Department | Initial Training Networks (ITN) |
Sector | Charity/Non Profit |
Country | Global |
Start | 09/2013 |
End | 08/2017 |
Description | Marie Curie Intra-European Fellowship (del Barrio) |
Amount | € 225,000 (EUR) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 03/2011 |
End | 02/2013 |
Description | Royal Society International Exchange (w/ Zhang, China) |
Amount | £12,100 (GBP) |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2013 |
End | 12/2015 |
Description | Royal Society Newton Fellowship (Angelova) |
Amount | £991,000 (GBP) |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2014 |
End | 01/2016 |
Description | Schlumberger Cambridge Research, PhD studentship 1 |
Amount | £136,100 (GBP) |
Organisation | Schlumberger Limited |
Department | Schlumberger Cambridge Research |
Sector | Academic/University |
Country | United Kingdom |
Start | 10/2008 |
End | 09/2012 |
Description | Schlumberger Cambridge Research, PhD studentship 2 |
Amount | £199,126 (GBP) |
Organisation | Schlumberger Limited |
Department | Schlumberger Cambridge Research |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2012 |
End | 01/2016 |
Description | UK-Weizmann Joint Research Programme |
Amount | $100,000 (USD) |
Organisation | Weizmann Institute of Science |
Sector | Academic/University |
Country | Israel |
Start | 04/2011 |
End | 03/2013 |
Title | Research data supporting 'Wu et al., Bioinspired supramolecular fibers drawn from a multi-phase self-assembled hydrogel, PNAS, 2017' |
Description | The attached three files contain the dataset for the article 'Wu et al., Bioinspired supramolecular fibers drawn from a multi-phase self-assembled hydrogel, PNAS, 2017'. |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Title | METHODS FOR THE PURIFICATION OF CUCURBITURIL |
Description | The present invention provides a method for purifying a cucurbituril from a mixture. The method comprises the step of forming a complex between the cucurbituril and a cucurbituril guest. The complex has altered physical and/or chemical properties to the cucurbituril which allow the complex to be separated from at least one other component of the mixture. The mixture comprises the cucurbituril, the other component and a solvent. |
IP Reference | WO2011077099 |
Protection | Patent application published |
Year Protection Granted | 2011 |
Licensed | Yes |
Impact | Ability to obtain individual CBs on large scale! Increased industrial interest. |
Title | SUPRAMOLECULAR HANDCUFFS IN POLYMERIC ARCHITECTURE |
Description | This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, wherein the first and second CB[8] guest molecules form a ternary host-guest complex with a CB[8] molecule which non-covalently links the polymeric molecule and the attachment compound in a supramolecular polymer. These polymers are useful as vehicles for delivery of a therapeutic compound for use in a method of treatment of the human or animal body, in particular for use in a method of delivering the therapeutic compound to a target site in an individual. The invention also provides methods for the preparation of the supramolecular polymers. |
IP Reference | US2010247477 |
Protection | Patent granted |
Year Protection Granted | 2010 |
Licensed | Yes |
Impact | A multitude of research grants from UK, European and international agencies. Attracted excellent PhD students and postdocs to my research group. Interest and funding from a number of industrial partners. |
Company Name | Aqdot |
Description | Aqdot is a spin-out company based on the cutting-edge research of the Department of Chemistry, University of Cambridge. It has developed a novel fabrication technology for smart capsules that possess customisable properties to suit the needs of a variety of industries. The Aqdot technology greatly simplifies the encapsulation process by utilising the novel one-step, "shrink-wrap" approach based on a combination of emulsion technology and supramolecular chemistry. |
Year Established | 2012 |
Impact | Team of 9 full-time employees Engaged with many leading Tier 1 and 2 companies Pre-joint development proof of principle programmes with leading international brand manufacturers Regulatory testing underway Freedom to operate - CB licenses bought Attractive economics from 1st engineering study Conceptual design shows standard process equipment Filed new patents with additional drafts ready for filing Paid £138K in historic IP costs to CE and University inventors Investment of £3.6M Awarded soft funding of £200K Pre-joint development proof of principle programmes with leading international brand manufacturers Publicity through international press including the BBC, Financial Times (six of hottest UK start-ups), The Observer, and Sunday Herald We were awarded the RSC Emerging Technology award, the Climate KIC UK Venture Competition Winner and European Runner-up |
Website | http://www.aqdot.com/ |