New Multi-Component Reactions For Array Synthesis
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Chemistry
Abstract
The project will develop new methods for so-called Multi-Component Reactions which will be able to generate arrays of amines and sulfonamides with a stereogenic (handed) centre next to the nitrogen functionality with complete control over each and every group attached to the nitrogen and the adjacent stereogenic carbon. The method will bring together up to six components in one reaction vessel to give single products in a predictable and controlled manner. By varying the six components any one of a huge number of potential chiral amines can be accessed, therefore allowing medicinal chemists easy access to either large numbers of chiral amines or specific sub-sets of chiral amines with ease and accuracy.
Publications
Roe C
(2011)
One-pot synthesis of chiral nonracemic amines.
in The Journal of organic chemistry
Roe C
(2011)
Multicomponent synthesis of chiral sulfinimines.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Roe C
(2011)
On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.
in Chemical communications (Cambridge, England)
| Description | We discovered a general, one-pot synthesis of chiral amines which does not require chromatography. |
| Exploitation Route | Used to make chiral amines for the fine chemicals or pharmaceutical industry. |
| Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | A number of chiral amines were made for GlaxoSmithKline |
| First Year Of Impact | 2012 |
| Sector | Pharmaceuticals and Medical Biotechnology |