New methods for assessing the control of blood flow in the brain
Lead Research Organisation:
University of Leicester
Department Name: Cardiovascular Sciences
Abstract
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People |
ORCID iD |
| R Panerai (Principal Investigator) | |
| John Potter (Co-Investigator) |
Publications
Angarita-Jaimes N
(2014)
Optimising the assessment of cerebral autoregulation from black box models.
in Medical engineering & physics
Fan L
(2013)
Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function.
in Medical & biological engineering & computing
Katsogridakis E
(2011)
Signal-to-noise ratio of bilateral nonimaging transcranial Doppler recordings of the middle cerebral artery is not affected by age and sex.
in Ultrasound in medicine & biology
Katsogridakis E
(2017)
Coherent averaging of pseudorandom binary stimuli: is the dynamic cerebral autoregulatory response symmetrical?
in Physiological measurement
Katsogridakis E
(2016)
Revisiting the frequency domain: the multiple and partial coherence of cerebral blood flow velocity in the assessment of dynamic cerebral autoregulation.
in Physiological measurement
Katsogridakis E
(2013)
Detection of impaired cerebral autoregulation improves by increasing arterial blood pressure variability.
in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Katsogridakis E
(2012)
Random perturbations of arterial blood pressure for the assessment of dynamic cerebral autoregulation.
in Physiological measurement
Mahdi A
(2017)
Increased blood pressure variability upon standing up improves reproducibility of cerebral autoregulation indices.
in Medical engineering & physics
Panerai RB
(2018)
Inter-subject analysis of transfer function coherence in studies of dynamic cerebral autoregulation.
in Physiological measurement
| Description | One key objective met was the design, construction and validation of a new device and data acquisition system, to induce random oscillations in arterial blood pressure and also in the delivery of carbon dioxide or other gases that can influence the regulation of blood flow in the brain. Testing of the new system demonstrated superior behaviour compared to more classical alternatives, with superior sensitivity and specificity in relation to assessments of dynamic cerebral autoregulation based on spontaneous fluctuations in arterial blood pressure. |
| Exploitation Route | Outcomes of the research have great potential for clinical use, including bedside assessment of cerebral blood flow regulation. The results of the project will be of great interest to investigators in the field of cerebral haemodynamics, neurologists and neurovascular surgeons. The new equipment produced has potential to be commercialised. Results will be disseminated through publications in peer-reviewed journals and scientific meetings. |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology |
| Description | Results from the project have been disseminated through international conferences and also published in the peer reviewed literature. These have contributed to important advances in the field and are gradually being cited in the literature. |
| First Year Of Impact | 2011 |
| Sector | Healthcare |
| Description | Research protocols |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in systematic reviews |
| Impact | Impact consisted of better awareness and changes in practice involving methods of data analysis and software needs for modelling non-invasive measurements of parameters in studies of cerebral blood flow in humans. |
| Description | White Paper |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | The Dunhill Medical Trust |
| Amount | £211,000 (GBP) |
| Funding ID | RTF97/0117 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2020 |
| Title | Cerebral autoregulation |
| Description | Several innovative techniques for assessment of cerebral blood flow regulatory mechanisms, including new hardware and software. Some of these techniques have the potential to be used in other areas of physiological measurements, such as studies of baroreceptor function, coronary and peripheral blood flow. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | Yes |
| Impact | Our group and collaborators who had access to these methods have been able to perform innovative studies leading to new insights into the mechanisms controlling cerebral blood flow in human. |
| Title | Multivariate modelling of cerebral blood flow regulation |
| Description | An innovative approach was implemented as a dynamic autoregressive moving average model of the main mechanisms controlling cerebral blood flow in humans. This ahs been successfully tested in recent studies in healthy subjects, as well as patients with acute ischaemic stroke. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | The successful implementation of this new approach has stimulated further studies including an on going analysis of cerebral blood flow in patients with Parkinson's Disease. |
| Title | TCD database |
| Description | Innovative analysis technique for modelling the regulation of cerebral blood flow in healthy subjects and patients with stroke and other cerebrovascular diseases. |
| Type Of Material | Data analysis technique |
| Provided To Others? | Yes |
| Impact | The data analysis and technique have allowed our group and collaborators to perform innovative studies of the mechanisms involved in the regulation of cerebral blood flow in healthy subjects and patients with stroke and other cerebrovascular conditions. The database has allowed a dedicated study leading to the following publication: Patel N, Panerai RB, Haunton V, Katsogridakis E, Saeed NP, Salinet A, Brodie F, Syed N, D'Sa S, Robinson TG 2016 The Leicester cerebral haemodynamics database: normative values and the influence of age and sex. Physiological Measurement 37:1485-1498. |
| Description | Department of Engineering University of Southampton |
| Organisation | University of Southampton |
| Department | Centre for Biological Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of dedicated hardware and software. Data collection and analysis. |
| Collaborator Contribution | Data collection and analysis. Joint preparation and submission of papers. |
| Impact | Construction of dedicated hardware. Joint publication of papers. Successful PhD awards. |
| Start Year | 2009 |
| Description | Department of Neurology, University of Sao Paulo, Brazil |
| Organisation | Universidade de São Paulo |
| Department | Department of Neurology, Psychiatry and Medical Psychology |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | This collaboration is on going since 2011 involving joint research and training of young investigators. The Cardiovascular Sciences Department, University of Leicester has provided training and mentoring to three young investigators from the Sao Paulo department. Our group has also contributed with data and software to joint research projects. |
| Collaborator Contribution | Our partners have contributed with data and analysis of combined data sets and have also taken a lead in the preparation of some of the research outputs. |
| Impact | Conference presentations and journal articles. Multi-disciplinary: medicine, physiology, medical physics, digital signal processing, mathematical modelling. |
| Start Year | 2011 |
| Title | Editing and analysis software |
| Description | Large number of dedicated Fortran programs for data editing and analysis. |
| Type Of Technology | Software |
| Year Produced | 2010 |
| Impact | Software has been shared with collaborators allowing a number of groups to perform innovative data analyses in the area of non-invasive physiological measurement. |
| Title | Software for modelling dynamic cerebral blood flow regulation |
| Description | Comprises a set of 20 different computer programmes to model the interaction of physiological variables that can reflect mechanisms of cerebral blood flow regulation. |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2008 |
| Impact | The software has allowed investigators in the UK, Portugal, The Netherlands, Brazil & Chile to perform data analyses of their own data, leading to original publications in the peer reviewed literature. |