Infrastructure and the 21st century infectious diseases

Lead Research Organisation: University College London
Department Name: Civil Environmental and Geomatic Eng

Abstract

My vision is within the next 10 years, we will revolutionise the way of thinking and practice in infrastructure function, design and construction to create a new environment which resists the 21st century infectious diseases.This project is about transforming and designing new infrastructure to combat the 21st century infectious diseases in the environment. This project is particularly important in the UK as it is burdened with the legacy of aged infrastructure; London underground and Bazalgette's sewerage system are more than 100 years old. Infectious diseases can bring great loss of life and suffering. Alongside the notorious hospital 'super-bugs', in the 21st century, one of the biggest threats from infectious diseases in the world is from the pathogens which can be transmitted via the airborne and surface contact routes, such as bird flu virus and SARS. According to the figures from the Department of Health, up to 750,000 extra deaths could be expected in Britain within 15 weeks of a flu pandemic. A quarter to half of the population may be infected and up to 2.5% of those could die. Although water-borne and food-borne pathogens can still be a problem, in the UK at least, these pathogens are generally guarded and regulated. Using the Health Protection Agency's contingency plan on Avian Flu as an example, surveillance and containment are the centre of the response strategy but the word Engineering is not shown in this document. My view is that infrastructure engineering is core to the solution of these problems. Engineering affects every single aspect of our life. Similarly, disease outbreaks are the results of a mixture of biological, environmental, social, economic and political aspects. It is certain that engineering can play a bigger part. Infrastructure may not stop disease transmission (unless it is the source of pathogens) but infrastructure can reduce the risk and extent of the pathogens reaching and infecting people. Infrastructure and infectious diseases can be linked in 4 different ways: Infrastructures which 1. directly kill or remove pathogens 2. become a source of pathogens 3. create an environment to facilitate disease transmission and 4. facilitate other non-engineering control measures.Infrastructure can make a difference in the fight against these infectious diseases. It is the aim of this proposal to develop a Healthy Infrastructure Research Centre (HIRC) to make it happen - a vibrant and exciting place for all people interested in knowledge, research and education about the ways in which infrastructure can be designed and operated to minimise infection. Medical and Health Science, Engineering and Technology and Social Science are the core subject areas to support the development of HIRC. By working in partnership, by the end of the funding period, 5 years, this multidisciplinary group will create 1) a new research centre which has the right facility and people, 2) new knowledge of the relationship between disease transmission, people and infrastructure and 3) new practice and novel engineering solutions to reduce infection transmission which can make a real difference in the world. It is not just the potential massive amount of casualties and fatalities that worries us but also the unpredictability and speedy transmission of new and emergent diseases that make this project in building a healthy infrastructures group extremely important and timeliness. Without this EPSRC funding support, this important research centre and many potential solutions for reducing or even stopping infectious disease transmission just will not happen.
 
Description This research grant had the following goals:

1 ) Development of a research centre (Healthy Infrastructure Research Centre - HIRC )

The centre and the laboratory was developed with a view to act acting as a hub for multidisciplinary research and education for environmental health challenges. The HIRC were fully functioned in Dec 2009. We held a launch party at UCL to celebrate and announce the vision and the facility of HIRC to the stakeholders and researchers around the UK. Since 2009, we have been producing research outcomes via publications in peer reviewed journals, contribution to book chapters and government reports, presentation in conferences, consultancy work, and public engagement activities.

2 ) Research the relationship between disease transmission, people and infrastructure

HIRC is particularly interested in airborne disease transmission in the environment. Bio-threats through the airborne route are diverse and getting more important in the 21st century with the extra complication, uncertainty and hazard from climate change, urbanisation and aging infrastructure as shown below. Our research in collaboration with other researchers and stakeholders (e.g. Public Health England, Hospitals, Universities/NGOs in developing countries) has advanced the knowledge on how various elements of infrastructure (design, construction and management) can influence the spread of airborne disease, whilst at the same time enhancing the evidence base to develop practical tools/strategies to mitigate infection risk in infrastructure. We have investigated the spatio/temporal distribution/dispersion/deposition of aerosols under different environmental conditions, both in controlled environments (Chamber) and real environments with a view to: inform sampling design and sampling strategies, develop detect to alarm tools and to predict the risk of occupants' exposure to airborne biological agents under different indoor environmental conditions. The analysis of results from chamber and office revealed a considerable impact of environmental conditions on aerosol dynamics (spatio/temporal correlation, decay) and revealed the potential of using particle number size profile to inform sampling design and strategies and as a tool to envisage ventilation efficiency in enclosed spaces. Additionally, studies carried out in different offices to evaluate the use of concentrations of CO2 as a tool to inform the vulnerability of built environment to airborne infection found that this can be used as a detect to alarm tool to continuously monitor the efficacy of mechanical ventilation systems. Our pioneering work on identifying the characteristic microbial community associated with different indoor environments has shown that different activities and inhabitants greatly influences the microbial population in infrastructure.

3) Propose new practice and novel engineering solutions to reduce infection transmission

It is timely and crucial to make science and technology work to reduce the risk from bio-threats. Our research focused on studying new practice and novel engineering solutions to reduce infection transmission by collaborating with frontline public health practitioners, clinicians, and people and organisations taking different roles in the society. Our work with hospitals has highlighted the degree of contamination by viruses and highlighted the case for the development of evidence-based infection control policy. Similarly we have proposed an environmental health assessment framework to evaluate the risk of a place on transmission of TB in collaboration with Public Health England. In addition, we have proposed, developed and tested different novel engineering solutions to control disease spread in different infrastructure. These included the use of different ventilation types, filtration, ultra violet germicidal irradiation, photocatalytic oxidation, multi barrier air treatment units and antimicrobial surfaces.
Exploitation Route Our work on using certain environmental characteristics (e.g. number and sizes of particles in the air, levels of carbon dioxide) as diagnostic tools to inform air health of a space can be advanced towards the development of detect to alarm or detect to treat systems to enhance the resilient of infrastructure to airborne disease transmission. Our proposed environmental health assessment framework in collaboration with Public Health England can assist in deciding the extent of contact screening in TB outbreak settings and can contribute greatly to develop the bio-resilience index of different infrastructure. Our findings from research work at different hospitals have a significant potential to the development of infection control policies/strategies. The work related to development of engineering solution for airborne disease control can be commercialised.
Sectors Communities and Social Services/Policy,Education,Environment,Healthcare,Security and Diplomacy,Transport

URL http://www.cege.ucl.ac.uk/HIRG/Pages/default.aspx
 
Description Environmental Health Investigations adjunct to contact TB screeing
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Grand Challenges Explorations Round 7
Amount £60,000 (GBP)
Funding ID OPP1044355 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 11/2011 
End 06/2014
 
Description Royal Society-DFID Africa Capacity Building Initiative
Amount £25,000 (GBP)
Funding ID AN130045 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2013 
End 06/2014
 
Description Environmental Health Investigations Adjunct to TB Contact Screening 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution We carried out environmental health investigation involving site assessment and environmental measurments in TB outbreak settings in order to: a) develop tools and environmental health assessment framework to inform the extent of contact screening b) develop tools and infrastructure vulnerability assessment framework to evaluate the infrastructure vulnerability to airborne disease transmission and serve as a support or guide to enhance its resilience to airborne disease transmission.
Collaborator Contribution LTBEx Team from PHE contributed towards a. Documentation of clinical and socio-demographic information of index cases, b. Contact screening information and results c. Storage of results in LTBEx database d. Analyse the strength of the association between different environmental parameters and TB transmission rates in each setting
Impact Combining environmental assessment and contact investigations to make tuberculosis screening decisions Environmental Health Investigations Adjunct to TB Contact Screening
Start Year 2012
 
Description Improvements in existing housing infrastructure as a tool to reduce the risk of TB transmission in slums 
Organisation Foundation for Medical Research (FRM)
Country France 
Sector Charity/Non Profit 
PI Contribution Technical experties, Reseach design, data analysis, numerical modelling
Collaborator Contribution On site administartion of questionnaire, site surveys, Data provision
Impact Preliminiry report was submitted to FMR and journal article is reday to be submit
Start Year 2012
 
Description Instrumentation and novel methods of bioaerosol sampling and analysis 
Organisation Defence Science & Technology Laboratory (DSTL)
Country United Kingdom 
Sector Public 
PI Contribution Sampling/experiment design, experimental work in environmental chamber, result analysis
Collaborator Contribution Result analysis, Numerical modeling
Impact Exponential decay rate estimation using time-integrated aerosol sampling of variable duration
Start Year 2012
 
Description Resilient Infrastructure and Building Security (RIBS) 
Organisation University College London
Department Department of Security and Crime Science
Country United Kingdom 
Sector Academic/University 
PI Contribution The Healthy Infrastructure Research Centre was responsible for the "Biological Threats" domain within the project. RIBS supported the development of biological protection measures to defend against pathogens. We investigated on what, when, where and how monitoring, detection and identification of biological agents should be performed to reduce the potential damage caused to the population in a building.
Collaborator Contribution They have contributed towards the consumbables (reagents, equipment) for the experimental work to study biosersols dynamics (dispersion, seposition and viability) under different scenarios. For example release of bio agent from parcel and air intake release in chamber.
Impact doi: 10.4172/2157-2526.1000123 doi:10.4172/2157-2526.1000116
Start Year 2011
 
Description Transnational Education Partnership Programme at the University of Punjab, Lahore 
Organisation University of the Punjab
Country Pakistan 
Sector Academic/University 
PI Contribution Technical and intectual support for capacity building for research and training in Environmental Health
Collaborator Contribution Carried out sampling campaigns on environmental health in different micro environments in Pakistan
Impact Assessment of airborne microflora in residential houses in Lahore,Pakistan Monitoring of PM2.5 arising from different cooking fuels in rural residential houses. Measurement of NO2 inside and outside various educational institutes of Lahore, Pakistan Indoor air quality in Lahore, Pakistan Airborne microflora and particulate matter in residential houses in Lahore, Pakistan
Start Year 2012
 
Description ARCHIVE Says Home Is Where the Health Is 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact HIRGs association with the Archive Institute in researching health in housing was reported.

Highlighted the connections between design and disease in commercial, outdoor and residential structures to wider public
Year(s) Of Engagement Activity 2011
 
Description Engineering is key to curbing the spread of infectious diseases 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was to report the vision and work carried out at HIRC.


The impact of infrastructure (design, construction and maintenance) on public health was and how engineering can intervenve to improve environmental health was shared with wider public.
Year(s) Of Engagement Activity 2009
 
Description How an interdisciplinary research Group can help to better understand and mitigate the environmental challenges of solid waste management 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact there was a lively debate on current challanges and barriers take interdisciplinary approaches to tackle environmental issues

This higlighted the need of holistic system approach involing all the stakeholders to design intervention for 21st century environmental challenges
Year(s) Of Engagement Activity 2011
 
Description International Counterterrorism Expo 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact HIRC was present at the International Counterterrorism Expo in London, describing their research on bioagent spread in indoor environments.

The research capacity of HIRC to develop dectect to alarm sytems and protection measures against biological agents of concrern in modren infrastructure was presented to stakeholders
Year(s) Of Engagement Activity 2012
 
Description Living cleanrooms 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The question about Can we apply current and future cleanroom technology to combat infectious disease transmission in various infrastructure was discussed in this article.

An initiative by HIRC to take cleanroom concepts into the wider environment to combat diseases was described to experts and wider public.
Year(s) Of Engagement Activity 2010
 
Description Research and traing visit from FMR India 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Training was provided to a researcher from FMR on different aspects of bioaerosol assessment and control covering Health effects, Sources and transmission, Size distribution - Environmental Measurments - - Sampling designs, Sampling strategies, Sampling methods, Sampling and analytical methods for airborne Mycobacterium - Filteration - Brief Literature review, Airborne patogen control Tehnologies - Methods to control TB, Environmental intervention for resource limited countries.


Expension of cross-disciplinarity of HIRC research, collaboration, partnerships and capacity building of institution in developing countries to provide solution to major global issues
Year(s) Of Engagement Activity 2011
 
Description Scientists warn of vuvuzela (Chinese) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Vuvuzela may be the unofficial tune of 2010 World Cup, but scientists warn that it maybe a tool to transmit respiratory diseases.

The potential of Vuvuzela use in growded places as public healt hazard was communicated to wider public
Year(s) Of Engagement Activity 2010
URL http://edition.cnn.com/video/data/2.0/video/world/2010/06/17/hsieh.vuvuzela.health.chinese.cnn.html
 
Description The Built Environment: Principles and practices for reducing health care associated infections 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact The vision, capacity and exiting research work from healthy infrastructure research centre was presented

Collaboration , especially from medical professional, was sought to enhance the engagement and bidge the gap between engineers and public health officials
Year(s) Of Engagement Activity 2011
 
Description Vuvuzelas 'may spread diseases 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This narrated the finding of a research work on Vuvuzelas that these not only cause noise pollution but may also spread diseases

The possible health impcts of using Vuvuzelas was relayed to general public
Year(s) Of Engagement Activity 2011
URL http://www.bbc.co.uk/news/health-13509220
 
Description Women in Engineering Taster Course 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact The day consisted of two talks by female engineers and visits to the laboratories with some hands-on activities.

This taster course has been of such impact as every year there is a long waiting list. Girls are really interested to know what engineering is about.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
URL http://www.ucl.ac.uk/women-in-engineering
 
Description Work Shadowing 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Laboratory visit and observation of some analytical methods.

The two 11 year girls that participated on this activity were very enthusiastic about environmental engineering.
Year(s) Of Engagement Activity 2013,2014