Micro- and nano-patterning of titanium surfaces for optimal osseointegration of orthopaedic implants
Lead Research Organisation:
University of Bristol
Department Name: Oral and Dental Science
Abstract
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Organisations
- University of Bristol (Lead Research Organisation)
- National Physical Laboratory (Collaboration)
- City University of Hong Kong (Collaboration)
- Chinese University of Hong Kong (Collaboration)
- Polytechnic University of Catalonia (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- AO Research Institute (Project Partner)
- University of Southampton (Project Partner)
People |
ORCID iD |
| Bo Su (Principal Investigator) |
Publications
Cao Y
(2018)
Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation.
in Scientific reports
Damiati L
(2018)
Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants.
in Journal of tissue engineering
Fisher LE
(2016)
Bactericidal activity of biomimetic diamond nanocone surfaces.
in Biointerphases
Fraioli R
(2017)
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.
in Scientific reports
Goriainov V
(2018)
Harnessing Nanotopography to Enhance Osseointegration of Clinical Orthopedic Titanium Implants-An in Vitro and in Vivo Analysis.
in Frontiers in bioengineering and biotechnology
Halai M
(2014)
Scanning electron microscopical observation of an osteoblast/osteoclast co-culture on micropatterned orthopaedic ceramics.
in Journal of tissue engineering
Hazell G
(2018)
Bioinspired bactericidal surfaces with polymer nanocone arrays.
in Journal of colloid and interface science
Hazell G
(2018)
Studies of black silicon and black diamond as materials for antibacterial surfaces.
in Biomaterials science
Ishak MI
(2023)
Enhanced and Stem-Cell-Compatible Effects of Nature-Inspired Antimicrobial Nanotopography and Antimicrobial Peptides to Combat Implant-Associated Infection.
in ACS applied nano materials
Mas-Moruno C
(2019)
Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants.
in Advanced healthcare materials
| Description | Current demographic changes indicate that people will grow older, yet at the same time want to stay flexible and sport active. In addition, the number of younger people needing orthopedic implants e.g. after severe sport injuries, is also growing. Titanium and its alloys have been widely used in orthopedic implants for many years. Yet with many patients the implant can become loose within a period of ten years, consequently leading to pain or inflammation. In a worst case scenario this will need revisionary surgery. There is a pressing need to develop orthopaedic implants with better performance and longer lifetime. It has been known that both surface chemistry and topography will affect cells in terms of their attachment, differentiation and proliferation. This project is aimed at exploring topographic cues of implant surfaces to modulate cellular behaviour, to achieve optimal mechanical interdigitation and direct bone bonding at the bone-implant interface. We have developed a range of micro- and nano-patterning technologies which are applicable and up-scalable to titanium implant manufacturing. They include electrochemical micro-machining, through-mask anodisation and block copolymer templated anodisation. We have identified optimal micro- and nano-features that are both osteoconductive and osteoinductive. This may lead to significantly improved osseointegration of orthopaedic implants. We have further extended micro-/nano-patterning of titanium to other clinically relevant materials such as ceramics and PEEK. |
| Exploitation Route | Journal publications |
| Sectors | Healthcare |
| Description | Follow-on in vivo testing is underway to move on to the next step of application |
| Sector | Healthcare |
| Description | Bristolbridge |
| Amount | £25,395 (GBP) |
| Funding ID | CHEM RB1768 (EP/M027546/1) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 04/2016 |
| Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
| Amount | £699,713 (GBP) |
| Funding ID | MR/S010343/1 |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2022 |
| Description | MRC Innovation Grant |
| Amount | £200,000 (GBP) |
| Funding ID | MR/N010345/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2018 |
| Description | Multiscale topographies to modulate cells and bacteria |
| Amount | £313,423 (GBP) |
| Funding ID | EP/K035142/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 12/2016 |
| Description | Research for Health |
| Amount | £24,590 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 11/2015 |
| Description | Antimicrobial diamond nanocones |
| Organisation | City University of Hong Kong |
| Country | Hong Kong |
| Sector | Academic/University |
| PI Contribution | Search for antimicrobial surfaces to tackle AMR problem |
| Collaborator Contribution | Provide diamond nanocone surfaces using a CVD and etching technique |
| Impact | A joint publication in Biointerphase Journal |
| Start Year | 2015 |
| Description | Cell-instructive materials |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Nanopatterning of Ti surfaces |
| Collaborator Contribution | Peptides functionalisation |
| Impact | Two joint publications. Two successful CASE studentships (EPSRC and BBSRC). Multidisciplinary collaboration in biomaterials, peptides chemistry, microbiology and stem cell biology |
| Start Year | 2015 |
| Description | In vitro and in vivo study of antimicrobial surfaces |
| Organisation | University of Cambridge |
| Department | Department of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration is underway through a PhD studentship of Cambridge University with Prof Matthew Allen to test the developed antimicrobial nano-surfaces in a rabbit model. |
| Collaborator Contribution | Prof Allen and his student will perform both in vitro and in vivo testing of our nanostructured surfaces in both 2D substrates and 3D printed implants. |
| Impact | This is a multi-disciplinary collaboration between materials and biological sciences. Joint publications and future grand application are expected. |
| Start Year | 2018 |
| Description | In vivo testing of nanopatterned Ti implants |
| Organisation | Chinese University of Hong Kong |
| Country | Hong Kong |
| Sector | Academic/University |
| PI Contribution | Sample preparation |
| Collaborator Contribution | Animal testing |
| Impact | Animal tests confirmed in vitro results, leading to three joint publications. |
| Start Year | 2013 |
| Description | Stem cell response to bactericidal nanospikes |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide bactericidal surfaces |
| Collaborator Contribution | In vitro and in vivo tests |
| Impact | multi-disciplinary, biomaterials and stem cell biology, at least one paper expected, possible follow on grant application |
| Start Year | 2015 |
| Description | cell-instructive surfaces |
| Organisation | Polytechnic University of Catalonia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Nanostructured surfaces: generation and characterisation |
| Collaborator Contribution | Functionalisation of nano-surfaces with cell-binding ligands to improve cell attachment while preventing bacterial growth |
| Impact | A joint publication in Scientific Reports. One more in preparation. |
| Start Year | 2017 |
| Title | Smart implants for orthopaedics and dentistry |
| Description | Under two EPSRC funding, we have been developing cell-instructive titanium implants for orthopaedic and dental applications. So far, materials development and in vitro testing have been carried out. The next step is in vivo testing and clinical trials. |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2016 |
| Development Status | Actively seeking support |
| Impact | Still under development, not yet |
| Description | Invited talk at Biointerface conference (Newcastle University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Up to 100 people attend this conference organised by the Newcastle University. A lot of interests were received on nanotopographical modulation of cells and bacteria for medical implant applications |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk in IDAR annul meeting, Slovenia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk of our work on biomimetic materials for dentistry triggered a subsequent research collaboration funded by MRC with Cardiff University |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited talk in a workshop organised by the Institute for Molecular Science and Engineering (IMSE) at Imperial College London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Audience from a number of different department at Imperial, including Materials, Medicine, Mathematics, Life Sciences, Chemical Engineering, Chemistry, and the Imperial NHS Trust attended. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited visits to Indian Institute of Technology and National Institute of Technology India |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Boosted possible collaborations with the two top institutions in India. Discussed possible funding from Newton Fund. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Plenary lecture 'Cell-instructive surfaces via nanotopography' in Euro Biomat, Germany 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Novel approaches to generate smart materials and surfaces |
| Year(s) Of Engagement Activity | 2015 |