Acoustic Localisation of Coronary Artery Stenosis
Lead Research Organisation:
Queen Mary University of London
Department Name: Sch of Medicine & Dentistry
Abstract
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People |
ORCID iD |
| Stephen Greenwald (Principal Investigator) | |
| M Birch (Co-Investigator) |
Publications
Banks HT
(2014)
High-order space-time finite element schemes for acoustic and viscodynamic wave equations with temporal decoupling.
in International journal for numerical methods in engineering
Banks HT
(2014)
Model validation for a noninvasive arterial stenosis detection problem.
in Mathematical biosciences and engineering : MBE
Brewin MP
(2015)
Characterisation of Elastic and Acoustic Properties of an Agar-Based Tissue Mimicking Material.
in Annals of biomedical engineering
Carola Kruse (Co-Author)
(2012)
Computational Methods for the diagnosis of coronary heart disease
Carola Kruse (Co-Author)
(2012)
Computational Methods for the diagnosis of coronary heart disease
John Whiteman (Co-Author)
(2012)
Development of novel methods of numerical computation as applied to wave propagation in viscoelastic media
Kruse C
(2014)
Time-Decoupled High Order Continuous Space-Time Finite Element Schemes for the Heat Equation
in SIAM Journal on Scientific Computing
| Description | The aims of this project were to investigate the possibility of detecting non-invasively, partial blockages in the coronary arteries (coronary atherosclerosis) of patients, ideally before overt symptoms are seen. Currently there are no methods available for the routine screening of this disease and, given its widespread occurrence, a simple screening device would greatly help to reduce the financial and social burden resulting the disease. We set out to exploit the observation that flow through partly blocked arteries can become turbulent and form fast moving jets. When these hit the wall of the artery in which they are travelling they can cause it to 'flutter' and this movement can be transmitted through the tissue in the chest resulting in similar although weaker movements of the skin, which can be detected by sensors placed on the skin. The first part of the work was to construct a simplified model of the chest wall using a gel like material and to measure its viscous and elastic properties in the range of frequencies known to be associated with disturbed flow through narrowed blood vessels. These simple experiments were successfully completed and the results published. At the same time our co-workers on the computational arm of the study developed a numerical simulation of these visco-elastic properties. The next step was to generate mechanically within the gels, disturbances of the same magnitude as those seen in real blood vessels and to measure the resulting movement at the surface. In these experiments the position and the magnitude of the disturbance, as well as the frequency of the waves generated by it was accurately known. At the same time the mathematical model was developed to describe the way in which the waves propagate through the gel so that, given a known disturbance at a known position, the movement of the surface at various positions resulting from the disturbance could be predicted and compared to our experimental measurements. This part of the study has been completed and the mathematical model is able, within limits, to produce a result which corresponds to the known position of the disturbance. At the same time, a second group of collaborators have been tackling the so called inverse problem. That is, given a pattern of disturbances at the surface of the gel, can one predict the position of their source? They too have shown that this is in principle possible and their methods will be used on the data that we are still gathering. The final part of the work, carried out during the tenure of the grant, was to produce a more realistic experimental model of a partially blocked coronary artery by embedding a tube (either with no obstruction therein or with partial blockages of varying severity) in the gel and measuring the pattern of movement at the surface caused by the flow (at various speeds) of a blood mimicking fluid within the tube. We were able to prove the principle that the disturbances can be detected by low cost sensors placed at its surface and by using a laser interferometer (an optical device able to detect minute movement) were able to verify that these disturbances gave rise to movements in the plane of the gel surface as well as at right angles to it. We had originally intended to carry out more extensive measurements of this type on progressively more realistic models of the chest but the tenure of the grant expired before we were able to complete this. However, we have secured further funding to carry out these measurements and to extend them to models of the carotid artery in the neck (also subject to atherosclerotic blockages) as well as to detect the movement of the carotid artery due to the pulse travelling within it. From this information we can determine the stiffness of the artery whether or not it is free of blockages. Arterial stiffness is now recognised as an effective indicator of the general health of the circulation and a reliable measure of the risk of cardiovascular disease and death. |
| Exploitation Route | Continuing measurements of the strain field at the surface of the gels using an array of miniature accelerometers are about to start. These will be augmented by direct measurement of the surface displacement using laser interferometry. Funding for this work, which will start in early 2015, has been secured through a Horizon 2020 grant (call H2020-ICT-2014-1). Local funding (Queen Mary Life Science Initiative Proof of Concept Fund) has been obtained and a multi sensor array has been constructed. Phantom measurements show that a stenosis can be localised by analysing the differences between signals from multiple microphones. A small validation trial on healthy volunteers and patients with symptoms of coronary artery disease undergoing coronary CT angiography, is planned for Autumn 2020. |
| Sectors | Healthcare |
| Description | So far no impact beyond academic publications. The next step is to demonstrate the potential clinical utility of the methods we have so far developed. |
| First Year Of Impact | 2014 |
| Sector | Healthcare |
| Description | EU Horizon 2020 (Call H2020-ICT-2014-1). Topic: ICT-26-2014 Photonics KET |
| Amount | € 274,059 (EUR) |
| Funding ID | H2020-ICT-2014-1 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Queen Mary University of London (QMUL), Institute of Bioengineering |
| Amount | £36,000 (GBP) |
| Funding ID | Not yet known |
| Organisation | Queen Mary University of London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2018 |
| Description | Research Institutes Research Catalyst Fund |
| Amount | £24,540 (GBP) |
| Organisation | Brunel University London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2017 |
| Description | Inverse solver |
| Organisation | North Carolina State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provided data for 1-dimensional numerical simulation of shear wave propagation in a viscoelastic medium |
| Collaborator Contribution | Development and validation of 1-dimensional numerical simulation of shear wave propagation in a viscoelastic medium |
| Impact | Publications listed elsewhere. All papers so far published involve all team members. |
| Start Year | 2010 |
| Description | Research Institutes Research Catalyst Project 2017 |
| Organisation | Brunel University London |
| Department | Centre for Child and Youth Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To work under Brunel University Research Catalyst funding to further develop the approach for noninvasive computational diagnosis of coronary artery disease. Experiments with tissue mimicking gels will be executed in a wet lab and they will be used to validate computer simulations based on finite element methods. |
| Collaborator Contribution | Ashraf Khir (Biomedical Engineering, Brunel) and Stephen E Greenwald (Queen Mary London) will carry out experiments in Khir's lab. Greenwald is giving approximately one day per month through the year to this project as an in-kind contribution. Paresh Date (Smart Power Networks, Brunel) brings expertise in particle filtering, an ingredient to the computational mathematics that will be prototyped to detect signal-generating lesions in soft tissue mimics. John R Whiteman and Simon Shaw (Structural Integrity, Brunel) will contribute expertise in the development of bespoke finite element methods. Emmanuel Drakakis (Imperial College London) brings his expertise in the design and specification of surface-mounted sensors. |
| Impact | None as yet. Very early days. |
| Start Year | 2016 |
| Description | Research Institutes Research Catalyst Project 2017 |
| Organisation | Brunel University London |
| Department | Smart Power Networks |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To work under Brunel University Research Catalyst funding to further develop the approach for noninvasive computational diagnosis of coronary artery disease. Experiments with tissue mimicking gels will be executed in a wet lab and they will be used to validate computer simulations based on finite element methods. |
| Collaborator Contribution | Ashraf Khir (Biomedical Engineering, Brunel) and Stephen E Greenwald (Queen Mary London) will carry out experiments in Khir's lab. Greenwald is giving approximately one day per month through the year to this project as an in-kind contribution. Paresh Date (Smart Power Networks, Brunel) brings expertise in particle filtering, an ingredient to the computational mathematics that will be prototyped to detect signal-generating lesions in soft tissue mimics. John R Whiteman and Simon Shaw (Structural Integrity, Brunel) will contribute expertise in the development of bespoke finite element methods. Emmanuel Drakakis (Imperial College London) brings his expertise in the design and specification of surface-mounted sensors. |
| Impact | None as yet. Very early days. |
| Start Year | 2016 |
| Description | Research Institutes Research Catalyst Project 2017 |
| Organisation | Brunel University London |
| Department | Structural Integrity Research Theme |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To work under Brunel University Research Catalyst funding to further develop the approach for noninvasive computational diagnosis of coronary artery disease. Experiments with tissue mimicking gels will be executed in a wet lab and they will be used to validate computer simulations based on finite element methods. |
| Collaborator Contribution | Ashraf Khir (Biomedical Engineering, Brunel) and Stephen E Greenwald (Queen Mary London) will carry out experiments in Khir's lab. Greenwald is giving approximately one day per month through the year to this project as an in-kind contribution. Paresh Date (Smart Power Networks, Brunel) brings expertise in particle filtering, an ingredient to the computational mathematics that will be prototyped to detect signal-generating lesions in soft tissue mimics. John R Whiteman and Simon Shaw (Structural Integrity, Brunel) will contribute expertise in the development of bespoke finite element methods. Emmanuel Drakakis (Imperial College London) brings his expertise in the design and specification of surface-mounted sensors. |
| Impact | None as yet. Very early days. |
| Start Year | 2016 |
| Description | Research Institutes Research Catalyst Project 2017 |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To work under Brunel University Research Catalyst funding to further develop the approach for noninvasive computational diagnosis of coronary artery disease. Experiments with tissue mimicking gels will be executed in a wet lab and they will be used to validate computer simulations based on finite element methods. |
| Collaborator Contribution | Ashraf Khir (Biomedical Engineering, Brunel) and Stephen E Greenwald (Queen Mary London) will carry out experiments in Khir's lab. Greenwald is giving approximately one day per month through the year to this project as an in-kind contribution. Paresh Date (Smart Power Networks, Brunel) brings expertise in particle filtering, an ingredient to the computational mathematics that will be prototyped to detect signal-generating lesions in soft tissue mimics. John R Whiteman and Simon Shaw (Structural Integrity, Brunel) will contribute expertise in the development of bespoke finite element methods. Emmanuel Drakakis (Imperial College London) brings his expertise in the design and specification of surface-mounted sensors. |
| Impact | None as yet. Very early days. |
| Start Year | 2016 |
| Description | Research Institutes Research Catalyst Project 2017 |
| Organisation | Queen Mary University of London |
| Department | Institute of Dentistry |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | To work under Brunel University Research Catalyst funding to further develop the approach for noninvasive computational diagnosis of coronary artery disease. Experiments with tissue mimicking gels will be executed in a wet lab and they will be used to validate computer simulations based on finite element methods. |
| Collaborator Contribution | Ashraf Khir (Biomedical Engineering, Brunel) and Stephen E Greenwald (Queen Mary London) will carry out experiments in Khir's lab. Greenwald is giving approximately one day per month through the year to this project as an in-kind contribution. Paresh Date (Smart Power Networks, Brunel) brings expertise in particle filtering, an ingredient to the computational mathematics that will be prototyped to detect signal-generating lesions in soft tissue mimics. John R Whiteman and Simon Shaw (Structural Integrity, Brunel) will contribute expertise in the development of bespoke finite element methods. Emmanuel Drakakis (Imperial College London) brings his expertise in the design and specification of surface-mounted sensors. |
| Impact | None as yet. Very early days. |
| Start Year | 2016 |
| Description | ICBME, 4-7 Dec 2013, Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | General international biomechanics and bioengineering meeting |
| Year(s) Of Engagement Activity | 2013 |
| Description | 15th International Conference on Biomedical Engineering (ICBME2013), Singapore 4-7 December 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Shaw and Greenwald presented at the 15th International Conference on Biomedical Engineering (ICBME2013), Singapore 4-7 December 2013. Greenwald: Computational diagnosis of coronary artery stenosis: experimental measurement of wave propagation in soft tissue mimicking gel Shaw: Towards Computational Diagnosis Of Coronary Artery Disease |
| Year(s) Of Engagement Activity | 2013 |
| Description | Artery 2013, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation to a specialist meeting. Attendees included cardiologists, vascular pathologists, bioemchanicians |
| Year(s) Of Engagement Activity | 2013 |
| Description | Barts Dragon's Den |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A meeting between clinicians at Barts Hospital and engineers from QMUL designed to encourage innovation leading to development of diagnostic or therapeutic devices, in which participants were asked to provide ideas for further exploitation and funding support. Each participant gave a brief presentation and a panel was convened to select ideas suitable for further support. Results pending as of 20/02/16. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Barts Research Evening, London, June 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A meeting designed to promote patient and public involvement in research at Barts NHS Trust. Presentation was received with enthusiastic questions and discussion. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Bioengineering 2013, Strathclyde |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Small general meeting to report (mainly) UK bioengineering research. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Chonburi 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | General seminar to members of the faculty of health sciences at a small university near Bangok. Purpose was to inform them of recent developments in non-invasive screening and diagnosis of cardiovascular disease. |
| Year(s) Of Engagement Activity | 2015 |
| Description | City University Bioengineering group 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | 1 hour seminar about work resulting from grant. Many questions and lively discussion. Collaboration started with one staff member concerning non-invasive measurement of endothelial function. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Computational and Mathematical Methods in Science and Engineering (CMMSE), July 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation by JR Whiteman at Computational and Mathematical Methods in Science and Engineering, Cadiz, July 3-7, 2014: Towards a Proof-of-Concept for Acoustic Localisation of Coronary Artery Stenosis |
| Year(s) Of Engagement Activity | 2014 |
| Description | Conference Presentation - ICBT 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled: Acoustic Localisation of Coronary Artery Disease: computational aspects At: International Conference on Biomedical Technology 28-30 October 2015, Hannover, Germany Minisymposium: Cardiovascular Biomechanics in Health and Disease |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.icbt15.uni-hannover.de |
| Description | Conference Presentation: USNCM 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference Presentation: Towards Computational Diagnosis of Coronary Artery Disease 13-th US national congress on computational mechanics, San Diego, USA, 26-30 July 2015 Minisymposium: Computational Modeling and Simulation of the Cardiovascular System |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://13.usnccm.org |
| Description | Conference Presentation: WCB 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference Presentation: Towards Computational Diagnosis Of Coronary Artery Disease 7th World Congress of Biomechanics from July 6-11, 2014, Boston (USA) Track: Tissue Biomechanics. Session: Arterial stiffness - measurement, modelling and pathophysiology |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://esbiomech.org/newsletter/esbiomech-newsletter-autumn-2013/7th-world-congress-of-biomechanics... |
| Description | Conference Presentation: WCCM 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference Presentation: Sharp Estimates for Some Problems with Fading Memory Minisymposium: Applications of error estimation and model adaptation in Computational Mechanics WCCM XI - ECCM V - ECFD VI - Barcelona 2014 11th World Conference on Computational Mechanics (WCCM XI) 5th European Conference on Computational Mechanics (ECCM V) 6th European Conference on Computational Fluid Dynamics (ECFD VI) Barcelona, 20th-25th July 2014 |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.wccm-eccm-ecfd2014.org/frontal/default.asp |
| Description | ESB Lisbon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation. Acoustic Localisation of Coronary Artery Stenosis Beneficiaries: Workers in related fields Contribution Method: Development of novel methods of numerical computation as applied to wave propagation in viscoelastic media Development of novel methods of numerical computation as applied to wave propagation in viscoelastic media |
| Year(s) Of Engagement Activity | 2012 |
| Description | ESB Patras |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Spirited discussion of the physical principles underlying the presented work Approached by two academics newly appointed to permanent positions in UK university. Asked to give general talk to their department (early 2014) and as a result have established formal collaboration with one, leading to input on a successful EPSRC "First Grant" application. (A. Bucci, University of Portsmouth.) Also approached by an established academic who proposed collaboration, leading to further funding as outlined elsewhere. |
| Year(s) Of Engagement Activity | 2013 |
| Description | ICBT 2015, Hannover, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation to a specialist International conference. Audience a mixture of engineers and biomedical scientists plus a few clinicians. Focus of meeting, cardiovascular mechanics in health and disease. Time of presentation: "Acoustic Localisation of Coronary Artery Disease." |
| Year(s) Of Engagement Activity | 2015 |
| Description | ICERM |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting Title: "From the Clinic to Partial Differential Equations and Back: Emerging challenges for Cardiovascular Mathematics" Presentation given but main reason for attendance was to gain in depth experience in a field related to my own, namely the scope of modern computational descriptions of biomedical systems and their application to clinical problems. Established ongoing contacts with mathematicians and clinicians working n related fields, although at this early stage, no concrete collaborations have emerged to date. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Khon Kaen 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to staff and students in Departments of Anatomy and Physiology as part of a long term collaboration with groups there. Lively discussion with many questions. Further collaboration in progress and additional funding to be applied for. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Khon Kaen 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Follow from previous year's research seminar. Again, lively discussion concerning the grant work as well as collaboration with the local cardiovascular research group, which continue. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Mathematical Analysis of Metamaterials and Applications Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker/participant at the Tsinghua Sanya International Mathematics Forum (TSIMF) Mathematical Analysis of Metamaterials and Applications Workshop, 5-9 December 2016. Specialist meeting to disseminate and engage on frontier research in the computational simulation of dispersive metamaterials. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://ymsc.tsinghua.edu.cn/sanya/2016/MAMAA2016/synopsis_and_organizers.aspx |
| Description | Outreach - Chiswick School, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach talk to Year 12 students on applications of maths, with our research on 'Acoustic Localisation of Coronary Artery Stenosis' given as a specific example. I will be invited back next year - the talk was very well received by teachers and students. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Outreach Talk - Peter Symonds College, Winchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Outreach talk to Year 12 students on applications of maths, with our research on 'Acoustic Localisation of Coronary Artery Stenosis' given as a specific example. I will be invited back next year - the talk was very well received by teachers and students. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Outreach Talk - Richmond College, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach talk to Year 12 students on applications of maths, with our research on 'Acoustic Localisation of Coronary Artery Stenosis' given as a specific example. I will be invited back next year - the talk was very well received by teachers and students. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Outreach Talk - Woking College, Surrey |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Outreach talk to Year 12, 13 students on applications of maths, with our research on 'Acoustic Localisation of Coronary Artery Stenosis' given as a specific example. I will be invited back next year - the talk was very well received by teachers and students. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Outreach talk - Harrow College, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach talk to Year 12, 13 students on applications of maths, with our research on 'Acoustic Localisation of Coronary Artery Stenosis' given as a specific example. I will be invited back next year - the talk was very well received by teachers and students. |
| Year(s) Of Engagement Activity | 2016 |
| Description | WCCM, Sao Paulo |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation. "Acoustic Localisation of Coronary Artery Stenosis" As plaque builds up in a coronary artery, blood flow past the stenosed region becomes turbulent and thus creates chaotically varying wall shear stresses in the wake. These shears drive low amplitude acoustic shear waves through the soft tissue in the thorax which then appear at the chest wall and can be measured non-invasively by placing sensors on the skin. This acoustic surface signature has the potential to provide a cheap non-invasive means of diagnosing coronary artery disease. In order to test this diagnostic tool, we are measuring shear wave propagation in agarose gel as a tissue mimicking material. Co-workers are writing software that will describe wave motion in these gels to simulate in silico the response of the chest wall to the shear waves generated by turbulence in a stenosed coronary artery. Additional collaborators are developing inverse solver software to determine, from the chest wall signal, the location of the causal stenosis in the thorax. We presented baseline results about the elastic properties of the gels, these data being necessary input for the computational modelling. In the longer term this may lead to the development of the screening tool mentioned above and, if successful, will provide clinicians and other health care professionals a simple and cost effective means of judging the likelihood of a patient's needing further assessment and diagnostic tests, all of which currently are expensive and carry significant risk to the patient. Thus the long term effect will be to reduce costs to the health service and risk to the patient. The short term impact was to raise awareness in the biomedical engineering community of our work and to allow discussion of our preliminary results with interested parties and to encourage suggestions from them about ways to enhance the experimental methods we have used. Beneficiaries: Workers in related fields Contribution Method: Baseline data about measurement of shear wave propagation in soft tissue Baseline data about measurement of shear wave propagation in soft tissue |
| Year(s) Of Engagement Activity | 2012 |
| Description | Workshop Presentation - BIRS 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop Presentation: Acoustic Localisation of Coronary Artery Disease Banff International Research Station, Canada Programme: Computational and Numerical Analysis of Transient Problems in Acoustics, Elasticity, and Electromagnetism January 17-22, 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.birs.ca/events/2016/5-day-workshops/16w5071 |
| Description | World Congress of Biomechanics, Boston |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lively discussion of results following questions mainly from bioengineers with a diverse range of interests including cardiology and biomechanics in general Request to exchange further information with groups working in related fields. |
| Year(s) Of Engagement Activity | 2014 |