Control Engineering Inspired Design Tools for Synthetic Biology
Lead Research Organisation:
University of Cambridge
Department Name: Engineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Cambridge (Lead Research Organisation)
- California Institute of Technology (Collaboration)
- University of California, San Diego (UCSD) (Collaboration)
- California Institute of Technology (Project Partner)
- ETH Zurich (Project Partner)
- Massachusetts Institute of Technology (Project Partner)
People |
ORCID iD |
| Jorge Goncalves (Principal Investigator) | |
| Alex Webb (Co-Investigator) |
Publications
David Hayden (Author)
(2013)
European Control Conference
Hayden D
(2017)
Network Identifiability from Intrinsic Noise
in IEEE Transactions on Automatic Control
Hayden David (Author)
(2012)
IEEE Conference on Decision and Control
Herrero E
(2012)
EARLY FLOWERING4 recruitment of EARLY FLOWERING3 in the nucleus sustains the Arabidopsis circadian clock.
in The Plant cell
J Adebayo (Author)
(2012)
IEEE Conference on Decision and Control
Kuan WL
(2015)
Modelling the natural history of Huntington's disease progression.
in Journal of neurology, neurosurgery, and psychiatry
Mombaerts L
(2019)
Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator
in PLOS Computational Biology
Pan W
(2018)
Identification of Nonlinear State-Space Systems From Heterogeneous Datasets
in IEEE Transactions on Control of Network Systems
| Description | We developed computational tools to reduce the complexity of building reliable bio-systems. The simplified framework and identification tools return predictable models directly from experimental data. This provides a deeper and simpler understanding of biological systems, helping design and synthesise novel biological systems. |
| Exploitation Route | The developed algorithms are not restricted to biological systems and can be applied to other fields. The software is in a standard language easily accessible to other researchers. |
| Sectors | Digital/Communication/Information Technologies (including Software),Healthcare |
| Description | The tools developed in this project have successfully been applied to other fields. In synthetic biology, the methodologies have been applied to model and then design predictable synthetic circuits. For example, in the context of a toggle switch, we could predict how certain choices of parameters would lead to bimodal or single mode systems. The algorithms have also been applied to model the progression of Huntington's disease in individual patients. From a patient's historical data, the algorithm predicts the future progression of the disease. |
| Sector | Digital/Communication/Information Technologies (including Software),Healthcare |
| Description | Collaboration with Caltech |
| Organisation | California Institute of Technology |
| Department | Control and Dynamical Systems (CDS) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Exchange of postdoc Dr Ye Yuan to the lab of Prof Richard Murray. |
| Collaborator Contribution | Dr Yuan worked closely with two researchers from Prof Murray's lab. |
| Impact | New research directions in synthetic biology. Conference paper was written together. |
| Start Year | 2014 |
| Description | UCSD Synthetic Biology summer school |
| Organisation | University of California, San Diego (UCSD) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Attendance and participation at the UCSD Synthetic Biology summer school |
| Start Year | 2012 |
| Description | Public Engement |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Webb demonstrated the role of oscillators in biological systems to the general public during Science Saturday. Dr Webb presented a display on the role of oscillators to the general public on Science Saturday NA |
| Year(s) Of Engagement Activity | 2013 |
| Description | Seminar at California Institute for Health and Environment |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Seminar at nu-PMU group |
| Year(s) Of Engagement Activity | 2015 |
| Description | Seminar at Caltech |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Seminar at the Dept of Control and Dynamical Systems Division |
| Year(s) Of Engagement Activity | 2015 |
| Description | Seminar at KTH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Give a seminar and discuss common research interests. NA |
| Year(s) Of Engagement Activity | 2012 |
| Description | Seminar at Lund University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Invitation to discuss recent results and start collaborations at Lund University with the group of Prof Rantzer. NA |
| Year(s) Of Engagement Activity | 2007,2012 |
| Description | Seminar at UC Berkeley |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Seminar at the EECS department. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Seminar at Zhejiang University |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Seminar at the Dept of Automation |
| Year(s) Of Engagement Activity | 2015 |