Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Philip Alan Gale (Principal Investigator) |
Publications
Berry SN
(2016)
Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells.
in Chemical science
Berry SN
(2015)
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism.
in Organic & biomolecular chemistry
Busschaert N
(2014)
Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport
in Chemical Science
Busschaert N
(2017)
A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations.
in Nature chemistry
Busschaert N
(2014)
Thiosquaramides: pH switchable anion transporters.
in Chemical science
Busschaert N
(2015)
Applications of Supramolecular Anion Recognition.
in Chemical reviews
Busschaert N
(2013)
Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
in Chemical Science
Cranwell PB
(2013)
Anion recognition and transport properties of sulfamide-, phosphoric triamide- and thiophosphoric triamide-based receptors.
in Chemical communications (Cambridge, England)
Edwards SJ
(2015)
High-affinity anion binding by steroidal squaramide receptors.
in Angewandte Chemie (International ed. in English)
Elmes RB
(2015)
pH switchable anion transport by an oxothiosquaramide.
in Chemical communications (Cambridge, England)
| Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
| Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
| Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Australian Research Council Discovery Grant 2018 |
| Amount | $524,708 (AUD) |
| Funding ID | DP180100612 |
| Organisation | Australian Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2018 |
| End | 12/2020 |