The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling
Lead Research Organisation:
Cardiff University
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| Damien Murphy (Principal Investigator) |
Publications
Bedford R
(2014)
Iron Phosphine Catalyzed Cross-Coupling of Tetraorganoborates and Related Group 13 Nucleophiles with Alkyl Halides
in Organometallics
Bedford R
(2014)
Iron-Catalyzed Borylation of Alkyl, Allyl, and Aryl Halides: Isolation of an Iron(I) Boryl Complex
in Organometallics
Bedford RB
(2014)
TMEDA in iron-catalyzed Kumada coupling: amine adduct versus homoleptic "ate" complex formation.
in Angewandte Chemie (International ed. in English)
Bedford RB
(2014)
Expedient iron-catalyzed coupling of alkyl, benzyl and allyl halides with arylboronic esters.
in Chemistry (Weinheim an der Bergstrasse, Germany)
| Description | The primary objectives from this research proposal were broadly met in striving to elucidate and understand the mechanism of Fe based cross coupling reactions. Working in partnership with colleagues in Bristol (Lead Group), Bath, and Princeton, our EPR group in Cardiff providing the underpinning evidence to demonstrate which oxidation states (low valent) of the Fe complexes were involved in the catalytic reactions. Using the advanced ENDOR technique, we were also able to demonstrate the role of the ligand in governing the overall structure of the catalysts in frozen solution. |
| Exploitation Route | Through the better design of new Fe based catalysts, by proving a better understanding of how the work and insights into the mechanism, may ultimately yield better catalysts that the chemical industry may seek to develop and commercialise. |
| Sectors | Chemicals |
| Description | The key findings from this research focussed on the valent state of the Iron complexes used in the important homogeneous C-C cross coupling reaction. For many years direct experimental proof for the low talent species of Fe were inclusive, and this research has certainly advanced our understanding of the electronic structure of the Fe species involved. Crucially, the research group in Bristol leading this project have been at the forefront in developing our understanding of how we can manipulate and utilise these earth abundant metals, such as iron, for catalytic conversions. There is now a growing awareness in the general media, and indeed in society, that elemental sustainability is becoming ever more important. Our dependencies on expensive (and in some cases toxic Pt group metals) must be reduced, whilst we find ways to optimise metals such as iron. So this research has indirectly helped to highlight the importance of using earth abundance metals from an environmental and elemental sustainability perspective. |
| First Year Of Impact | 2015 |
| Sector | Chemicals |
| Impact Types | Societal |