Directed Assembly Grand Challenge Network Continuation

Lead Research Organisation: University of Bath
Department Name: Chemistry

Abstract

The vision of the Network is to be able to control the assembly of matter with sufficient certainty and precision to allow preparation of materials and molecular assemblies with far more sophisticated and tuneable properties and functions than are accessible in materials synthesised using current methods.

In this Grand Challenge we aim to gain unprecedented control of the assembly of molecules that are the building blocks of many functional materials, consumer and industrial products. We start by understanding the assembly of the very small, but methods we explore will allow production of new types of useful materials at a whole range of length scales from the nano-scale to the everyday. Such materials will have outstanding impact in areas of societal importance such as personalised healthcare and food production, transport systems and fuel production, housing construction and consumer electronics. Through this intelligent approach to design we will compete effectively with the USA, Japan and mainland Europe to place the UK firmly at the forefront of developments in the areas of manufacturing, healthcare and energy.

The added value that the Network provides is in gathering the widest group of internationally-leading expert scientists from across a range of disciplines in the UK, and providing them with a challenge, a focus and a vision that they help shape.

Ongoing economic prosperity in the UK is critically dependent on having a competitive, high-tech manufacturing industry. Some areas of the Directed Assembly Network's activities address barriers to progress in existing industries, others will create the transformative industries of the future. Society is challenged by a growing and aging population, and through declining natural resources. The goals we reach for will drive great breakthroughs in healthcare and offer alternatives to harvesting our limited reserves.

The UK has already been identified as being world-class or world-leading in many of the individual disciplines needed to tackle these targets, but real breakthroughs will only be made by harnessing interdisciplinary excellence from across the UK - the Directed Assembly Network is key to the formation and maintenance of this interdisciplinary community. Other countries are already investing heavily in programmes to progress materials science; by adopting the recommendations above, the UK can enhance its scientific capability and keep pace at international levels, develop absorptive capacity and retain the competitive advantage needed to be a world player in the field of future manufacturing.

Planned Impact

The research field of directed assembly has great relevance in many areas affecting the society of the future, including healthcare and transport.
With an aging population, improved healthcare becomes more important - understanding directed assembly allows improvements in drug delivery and opens up the use of new therapeutic molecules as well as the development of bio-compatible, implantable materials, devices and organs.
With current concerns around long-term fuel supplies and polluting end-products, the applications of controlled molecular assembly are highly relevant. Transport systems can be made more environmentally-friendly and energy efficient through the use of improved fuel cells, better catalysts and, in the longer term, the possibility of using high-temperature superconductors.

Our work and leisure activities will be enhanced by new consumer electronics based around improved batteries, printable and organic electronics and new display devices.

Whilst the most obvious uses of a better understanding of molecular assembly are around creating faster, more efficient chemical synthesis methods and reclamation techniques, a whole range of new technologies are opened up through its application.

For example: smart, functionalised, structural materials which can incorporate energy-generation will transform the construction industry; anti-corrosion and anti-fouling treatments for surfaces will improve pipeline flows and the lifetimes of exposed metal; foodstuffs and drug production and delivery will be enhanced by better insight into nucleation, dissolution and the formation of gel structures.

By linking together academic expertise and industrial requirements and helping develop an understanding of each other's operating cultures, the Directed Assembly Network assists in speeding the uptake of new technologies into production processes, thereby maintaining the UK's industrial competitiveness.

Publications

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Neal EA (2016) A Kinetic Self-Sorting Approach to Heterocircuit [3]Rotaxanes. in Angewandte Chemie (International ed. in English)

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Price SL (2014) Predicting crystal structures of organic compounds. in Chemical Society reviews

 
Description We have continued to develop the Grand Challenge Network in Directed Assembly and have built a community of over 1000 academic and industrial members across the physical and life sciences. The Network has held targeted meetings, sandpits, early career events, and summer schools. We have an updated roadmap plotting out how the chemical grand challenges over the next 20-50 years may be met.

A themed area in the Central Journal of Chemistry has been set up and a dozen articles have already been published in this area, focused on developing aspects of the Network.Several reviews of key aspects of the directed assembly process have now been included.

An updated roadmap developed by the Network has been published in 2017.
Exploitation Route Through the community that we have built exciting new collaborations have been formed, funding from the EPSRC obtained, and high quality new science carried out. The DA Network underpins the community.
Sectors Agriculture, Food and Drink,Chemicals,Education,Electronics,Energy,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://www.directedassembly.co.uk/index.html
 
Description In the continuation of the Network we have grown the community to over 1000 members encompassing academics and industrialists from across the physical and life sciences, the majority based in the UK. We have updated the roadmap and continued to hold series of targeted meetings, summer schools, sandpits and early career meetings. Through pump priming awards we have helped (early career) investigators develop their own research. A number of the projects developed in the themed meetings and sandpits have resulted in the submission of grant applications to the EPSRC and other national and international funding bodies. The success of the continuation of the Network has been rewarded with a further renewal in January 2017 for three years. An updated roadmap has been published in 2017 that will be used as the blueprint for future developments targeted at meeting teh Grand Challenges.
Sector Agriculture, Food and Drink,Chemicals,Electronics,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description Directed Assembly Roadmap 2017
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
Impact The raodmap, as did the 2012 edition, is influencing the way that academics and industrialists think about Grand Challenge problems and how they can be solved.
URL https://figshare.com/articles/Directed_Assembly_Network_-_A_Roadmap_to_Innovation_2017_Edition/44835...
 
Description Responsive Mode
Amount £686,049 (GBP)
Funding ID EP/K014382/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2012 
End 12/2016
 
Description Responsive mode
Amount £254,037 (GBP)
Funding ID EP/P007279/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Sandpits 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Each year three or four sandpits have been run to tackle specific Directed Assembly-related topics. These sandpits have run for three days each. During the sandpits a number of consortia have formed, developed their ideas, and in the majority of cases have submitted proposals to the EPSRC or other funding bodies.
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.directedassembly.co.uk/phases.html
 
Description Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In 2014 and 2016 summer schools (duration of a week) were run in Cambridge targeted at post graduate students to teach them all aspects of science related to Directed Assembly
Year(s) Of Engagement Activity 2014,2016
URL http://www.directedassembly.co.uk/phases.html
 
Description Themed workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Workshops have been used to identify key challenges relating to Directed Assembly, assessing the barriers and producing ideas and proposals to tackle them.
Year(s) Of Engagement Activity 2014,2015,2016