Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants
Lead Research Organisation:
University of Bristol
Department Name: Oral and Dental Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Bristol (Lead Research Organisation)
- University of Science and Technology Beijing (Collaboration)
- National Physical Laboratory (Collaboration)
- Renishaw (United Kingdom) (Collaboration)
- City University of Hong Kong (Collaboration)
- Polytechnic University of Catalonia (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Beddoes CM
(2016)
Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage.
in Materials (Basel, Switzerland)
Cao Y
(2018)
Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation.
in Scientific reports
Damiati L
(2018)
Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants.
in Journal of tissue engineering
Diu T
(2014)
Cicada-inspired cell-instructive nanopatterned arrays.
in Scientific reports
Dunseath O
(2019)
Studies of Black Diamond as an antibacterial surface for Gram Negative bacteria: the interplay between chemical and mechanical bactericidal activity.
in Scientific reports
Fisher LE
(2016)
Bactericidal activity of biomimetic diamond nanocone surfaces.
in Biointerphases
Fraioli R
(2017)
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.
in Scientific reports
Goriainov V
(2018)
Harnessing Nanotopography to Enhance Osseointegration of Clinical Orthopedic Titanium Implants-An in Vitro and in Vivo Analysis.
in Frontiers in bioengineering and biotechnology
Halai M
(2014)
Scanning electron microscopical observation of an osteoblast/osteoclast co-culture on micropatterned orthopaedic ceramics.
in Journal of tissue engineering
Hazell G
(2018)
Bioinspired bactericidal surfaces with polymer nanocone arrays.
in Journal of colloid and interface science
| Description | We have identified that certain nanotopographies possess antimicrobial properties while directing stem cells into osteogenesis, a important step for the design of 'cell-instructive' smart implants |
| Exploitation Route | Implant manufacturers and tissue engineering researchers may find it useful to fabricate functional materials or scaffolds with antimicrobial performance |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology |
| Description | (Bio-TUNE) - Fine tune of cellular behavior: multifunctional materials for medical implants |
| Amount | € 814,200 (EUR) |
| Funding ID | 872869 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2020 |
| End | 12/2023 |
| Description | Biophysical stimulation-enhanced antimicrobial surfaces to combat implant-associated infections |
| Amount | £53,991 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 05/2018 |
| Description | Bristolbridge |
| Amount | £25,395 (GBP) |
| Funding ID | CHEM RB1768 (EP/M027546/1) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 04/2016 |
| Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
| Amount | £699,713 (GBP) |
| Funding ID | MR/S010343/1 |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2022 |
| Description | MRC Innovation Grant |
| Amount | £200,000 (GBP) |
| Funding ID | MR/N010345/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2018 |
| Description | Multiscale topographies to modulate cells and bacteria |
| Amount | £313,423 (GBP) |
| Funding ID | EP/K035142/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 12/2016 |
| Description | emPOWER: in-body artificial muscles for physical augmentation, function restoration, patient empowerment and future healthcare |
| Amount | £6,142,804 (GBP) |
| Funding ID | EP/T020792/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 08/2025 |
| Title | Analysis of osteoclastogenesis / osteoblastogenesis on nanotopographical titania surfaces. |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Title | Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Description | 3D printed Ti implants |
| Organisation | Renishaw PLC |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Provide 3D printed Ti implants for surface nanopatterning |
| Collaborator Contribution | Provide samples of 3DP Ti blocks for surface patterning and microbiological testing |
| Impact | Advanced manufacturing and medical devices |
| Start Year | 2020 |
| Description | Antimicrobial diamond nanocones |
| Organisation | City University of Hong Kong |
| Country | Hong Kong |
| Sector | Academic/University |
| PI Contribution | Search for antimicrobial surfaces to tackle AMR problem |
| Collaborator Contribution | Provide diamond nanocone surfaces using a CVD and etching technique |
| Impact | A joint publication in Biointerphase Journal |
| Start Year | 2015 |
| Description | Cell-instructive materials |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Nanopatterning of Ti surfaces |
| Collaborator Contribution | Peptides functionalisation |
| Impact | Two joint publications. Two successful CASE studentships (EPSRC and BBSRC). Multidisciplinary collaboration in biomaterials, peptides chemistry, microbiology and stem cell biology |
| Start Year | 2015 |
| Description | In vitro and in vivo study of antimicrobial surfaces |
| Organisation | University of Cambridge |
| Department | Department of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration is underway through a PhD studentship of Cambridge University with Prof Matthew Allen to test the developed antimicrobial nano-surfaces in a rabbit model. |
| Collaborator Contribution | Prof Allen and his student will perform both in vitro and in vivo testing of our nanostructured surfaces in both 2D substrates and 3D printed implants. |
| Impact | This is a multi-disciplinary collaboration between materials and biological sciences. Joint publications and future grand application are expected. |
| Start Year | 2018 |
| Description | Novel 3D Printed Ti implants |
| Organisation | University of Science and Technology Beijing |
| Country | China |
| Sector | Academic/University |
| PI Contribution | The USTB provides newly developed 3D printed Ti alloy implants for surface nanostructuring at University of Bristol. |
| Collaborator Contribution | We carry out nanopatterning of Ti implants and stem cells/microbiological studies to produce cell-instructive surfaces. |
| Impact | So far, 3 joint publications were obtained. |
| Start Year | 2020 |
| Description | Stem cell response to bactericidal nanospikes |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide bactericidal surfaces |
| Collaborator Contribution | In vitro and in vivo tests |
| Impact | multi-disciplinary, biomaterials and stem cell biology, at least one paper expected, possible follow on grant application |
| Start Year | 2015 |
| Description | cell-instructive surfaces |
| Organisation | Polytechnic University of Catalonia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Nanostructured surfaces: generation and characterisation |
| Collaborator Contribution | Functionalisation of nano-surfaces with cell-binding ligands to improve cell attachment while preventing bacterial growth |
| Impact | A joint publication in Scientific Reports. One more in preparation. |
| Start Year | 2017 |
| Title | Smart implants for orthopaedics and dentistry |
| Description | Under two EPSRC funding, we have been developing cell-instructive titanium implants for orthopaedic and dental applications. So far, materials development and in vitro testing have been carried out. The next step is in vivo testing and clinical trials. |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2016 |
| Development Status | Actively seeking support |
| Impact | Still under development, not yet |
| Description | Big Bang Bristol |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Big Bang Bristol was a free two-day science, technology, engineering and maths (STEM) extravaganza at the Trinity Arts Centre, Bristol, in July 2017. Visitors will be able to learn about the world-class research taking place in the region, find out about life as a postgraduate and how to become a professor. We have participated and showcased our research on bio-inspired bactericidal nanospike surfaces which attracted a lot of interests in our research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Biofilm Create! Competition 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A competition organised by the National Biofilm Innovation Centre funded by the UKRI (BBSRC). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.biofilms.ac.uk/biofilm-create-competition-2022-winners/ |
| Description | FUTURES festival on 30th Sep 2022 held in SS Great Britain, Bristol |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Outreach event to showcase researches in the University |
| Year(s) Of Engagement Activity | 2023 |
| Description | From deep-sea sponges to dragonfly wings: Superbug research from unexpected places |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media coverage of our work on 'fighting bacteria using bio-inspired materials'. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://mrc.ukri.org/news/blog/from-deep-sea-sponges-to-dragonfly-wings-superbug-research-from-unexp... |
| Description | Invited Talk , Advanced Powder Materials Online Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online event organised by the Central South University of China |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited lecture, London Interdisciplinary Biosciences Consortium, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | PhD students based in BBSRC DTP in London Interdisciplinary Biosciences Consortium attended this lecture. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited talk at 'antimicrobial surfaces' workshop (Sheffield University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 100 people attended this workshop on antimicrobial surfaces organised by Sheffield University. Our bio-inspired antimicrobial surfaces sparked a lot of interests in seeking alternative therapies for antibiotic-resistance problem. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk at Biointerface conference (Newcastle University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Up to 100 people attend this conference organised by the Newcastle University. A lot of interests were received on nanotopographical modulation of cells and bacteria for medical implant applications |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk at IUMRS2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International conference invited talk |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk at National Honey Show |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give a talk on our research in insect wing inspired antimicrobial surfaces to beekeepers and general public. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk in a workshop organised by the Institute for Molecular Science and Engineering (IMSE) at Imperial College London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Audience from a number of different department at Imperial, including Materials, Medicine, Mathematics, Life Sciences, Chemical Engineering, Chemistry, and the Imperial NHS Trust attended. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited talk in an international conference of Advanced Materials organised by Newcastle University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International audience mostly from Europe attended this conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited visits to Indian Institute of Technology and National Institute of Technology India |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Boosted possible collaborations with the two top institutions in India. Discussed possible funding from Newton Fund. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Invited visits to Shang Institute of Ceramics and Zhejiang University, China |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Boosted collaboration with two top research institutions in China. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Keynote lecture in International Forum and Silk Road Conference on Advanced Functional Films and Coatings, Xi'an, China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The intended purpose of this international forum was to exchange the latest research information on surface engineering. i was invited to give a keynote lecture on our work on antimicrobial surfaces. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keynote lecture, International Conference on Emerging Trends of Healthcare Technology in Post-COVID-19 Era, Indian Institute of Technology, Kharagpur, India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | An online international conference organised by IIT Kharagpur, India. The intended purpose was to report latest development in medical technology in post-COVID-19 era. I was invited to give a keynote lecture on our work on smart implants. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Kill superbugs with nanospears |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Research without boarders |
| Year(s) Of Engagement Activity | 2018 |
| Description | Nanobio workshop, Leuven, Belgium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at Nanobio workshop, organised by Vision Dynamics Science & Entrepreneurship. Audiences are mainly from European universities and SMEs. Disseminated our work to wider communities. A collaboration was initiated in this workshop with a UK company (Nanokicking) based in Glasgow. |
| Year(s) Of Engagement Activity | 2017 |
| Description | National Biofilms Innovation Centre (NBIC) All Research Partner meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Researchers and industrial partners to exchange information of their research under the NBIC memberships |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.biofilms.ac.uk/ |
| Description | Plenary lecture 'Cell-instructive surfaces via nanotopography' in Euro Biomat, Germany 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Novel approaches to generate smart materials and surfaces |
| Year(s) Of Engagement Activity | 2015 |
| Description | Plenary talk at Hunan Bone Summit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk to doctors and university |
| Year(s) Of Engagement Activity | 2016 |
| Description | Poster presentation, Infection and Immunity Research Network Early Career Researchers' event, University of Bristol, 1st Feb 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual event organised by the University, esp. for ECRs |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation, The 8th Thesinge Biofilm Conference, May 23-24, 2022, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An international conference held biennially with about 200-300 participants from academia and industries. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://biofilm-thesinge.com/index.php |
| Description | RSC Poster 2023 - Twitter Conference |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online conference organised by the RSC. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.rsc.org/our-events/rsc-poster/ |