MEASURING AND REPRODUCING THE 3D APPEARANCE OF HUMAN FACIAL SKIN UNDER VARYING ILLUMINATION CONDITIONS: A 3D IMAGING SYSTEM FOR HUMAN FACIAL SKIN

Lead Research Organisation: University of Liverpool
Department Name: Institute of Psychology Health & Society

Abstract

Understanding human skin appearance is a subject of great interest in science, medicine and technology. In medicine, skin appearance is a vital factor in surgical/prosthetic reconstruction, medical make-up/tattooing and disease diagnosis. The production of facial prostheses to replace missing facial structures requires the skills of highly trained anaplastologists to correctly match the shape and colour of the prosthesis to that of the host skin. With the 3D printing of human skin now available the process involved in matching natural and manufactured skin samples has become essential; a robust, accurate and efficient imaging system is required that acquires the relevant skin information and predicts a good match and translates this information through this new and innovative manufacturing process.

A major problem with manufactured skin is that the match to the individual's natural skin must hold not only be accurate under a particular ambient illumination but the match needs to be preserved when the individual is moving between different environments, e.g. when the individual moves from office or LED lighting into daylight. To achieve this illumination invariance, the physical properties of the skin need to be taken into account. A further requirement for successful skin reproduction is the development of appearance models. These can be considered as individual "recipes' or 'blueprints" for each skin type and these not only represent inter-personal differences - different ethnic groups and age ranges, but also intra-personal differences - for each individual. Features of the human skin (wrinkles, pores, freckles, spots etc) make human skin as individual as a finger prints and thus, for facial prosthetics applications, skin appearance models also need to be fine-tuned for each individual area.

The purpose of this work is to develop a complete spectral-based 3D imaging system which will allow us to additively manufacture soft tissue prosthetics or deliver predictable tattooing techniques that will exactly match the skin colour of a particular individual (Application 1) or have the capability to rapidly manufacture/3D print soft tissue replacements representative of a particular ethnic/age/gender group with a high degree of accuracy (Application 2). In application 1, the input to this 3D imaging system will consist of a 3D colour skin image (of a particular individual) obtained with a 3D camera in conjunction other specific skin characteristics. The skin sample will then be printed using a printer profile that maximises the match between the natural and printed skin across different ambient illuminations. In application 2, the skin manufacturing process will not be fine-tuned for a particular individual, but input to the 3D imaging system will consist of basic information about the age, gender and ethnicity. Representative skin samples (colour; texture; translucency; geometry) for this group will then be loaded from a pre-computed library instead of using the measurements from an individual.

Planned Impact

1. Healthcare provision for general population: In medicine, skin appearance is a vital factor in surgical/prosthetic reconstruction, medical make-up/tattooing, disease diagnosis (e.g. skin cancer) and evaluation of phototherapy.
2. Individualised health care: With 3D printing of skin on the horizon (see quotation and supporting statement from Fripp Design & Research), a robust and quick method to predict the appearance of skin prostheses is essential. With the knowledge gained in this project the skin manufacturing processes (traditional or new) can be tailored to individual patients to allow for colour shifts that occur during the production of facial prostheses. Quantitative colour models will allow clinicians to understand and improve predictions of colour changes that occur in donor tissues following reconstructive procedures. It may also allow for tissue selection based of predictive colour/aesthetic outcomes rather than solely on operator preference or "ease of harvest". These could be tailored to patient specific requirements and outcomes.
3. Cosmetic Industry: The aesthetic relevance of skin appearance has led to an enormous investment in skin research, mostly for make-up development and cosmetic surgery. Accurate models of skin appearance, particularly under a change in ambient illumination, is vital for the production of skin make-up and will therefore support the UK economy.
4. Entertainment industry: The advent of new lighting technologies (LEDs) and image capture/projection systems generates new challenges for rendering skin on displays and this project will help developers in the entertainment industry to improve the rendering of human faces (see the attached supporting statement from SONY)
5. National Security/Government: Computer vision systems for people tracking and face recognition used in national security applications rely on realistic skin appearance models. With the advent and continued evolution of high definition security/CCTV camera systems on the horizon, colour recognition as well as geometric recognition models will be vitally important.
6. CIE requirements: The CIE (Commission Internationale de l'Eclairage) is an international organisation that is active in all professional matters related to light, lighting and image technology. While the CIE cannot be a project partner, Professor Mike Pointer (CIE, Division I; see supporting letter) will provide his expertise on the acquisition process of the skin spectra and RGB images, which will then feed into the CIE committee on skin data bases (Reporter: KX, the co-investigator). Via the CIE the data bases will be made available for bench marking purposes to the computer vision and lighting/engineering community.
7. Lighting, Engineering and Virtual Reality applications: Accurate rendering or simulation of human faces under different viewing conditions relies on satisfactory spectral reconstruction algorithms for facial skin and on a knowledge of the perceptual tolerance to skin tone and texture distortions. The outcome of this project will therefore benefit these emerging industries (see the attached supporting letter from OPTIS).
8. Prosthetics industry: The Skin colour database and spectral reconstruction techniques of skin colour from digital camera images is essential for skin colour formulation used in the prosthetics industry. The outcome of this project will therefore benefit these industries (see supporting letter from SpectroMatch)
9. Public Engagement Activities. After the successful completion of the proposed research we intend to put on a 3-months-long installation at the World Museum in Liverpool. Visitors will be able to have their 3D face picture taken and then manipulated. They will be able to manipulate their 3D facial image by making their skin look younger or older, change their skin texture, and view their face using the skin colour and texture of a different ethnicity.
 
Description Understanding human skin appearance is a subject of great interest in science, medicine and technology. In medicine, skin appearance is a vital factor in surgical/prosthetic reconstruction, medical make-up/tattooing and disease diagnosis. With the 3D printing of human skin now at the horizon, the process involved in matching natural and manufactured skin samples has become essential; a robust, accurate and efficient imaging system is required that acquires the relevant skin information and predicts a good match and translates this information through this new and innovative manufacturing process. A major problem with manufactured skin is that the match to the individual's natural skin must hold not only be accurate under a particular ambient illumination but the match needs to be preserved when the individual is moving between different environments, e.g. when the individual moves from office or LED lighting into daylight. To achieve this illumination invariance, the physical properties of the skin need to be taken into account.

With funding from the EPSRC we were able to refine skin printing technology, with the following outcomes:

(i) Proof-of-concept for the acquisition and additive manufacture of skin using a 3dMD photogrammetry facial system (3dMD, Atlanta, GA, USA).and a powder-based 3D printing system (Zcorp Z510) [1,3,6]

(ii) Assessment of the skin measurement reliability of two instruments (PhotoResearch PR650 spectroradiometer; Konica Minolta CM700d spectrophotometer) [5]

(iii) An algorithm for the spectral reconstruction of full skin spectra from camera [2]

(iv) Publicly accessible data base characterising the variability of natural skin colour [4]

(v) Appearance evaluation of natural and manufactured skin using spectral and perceptual error metrics [6,7]

In summary, we were able to addivitively manufacture skin (facial prosthetics) with good colour accuracy (comparing real skin with additively manufactured skin) which would be considered as acceptable in real-world scenarios. Also the spectral properties of the facial prosthetics were similar to natural skin, hence the colour appearance match (between printed and natural skin) is not significantly dependent on the prevailing illumination. However, our previous manufacturing method relied on post-processing techniques (infiltration with silicone) to increase the flexibility and durability of the manufactured skin, which also leads to poorly controlled textures and highlights. For clinical applications, these highlights would not be acceptable.

With recent developments in 3D printing, allowing direct deposition of photocurable polymers with layer thickness < 15 mm and material specification at voxel resolution, we can address these shortcomings to optimise the optical and biomechanical properties.

Publications

[1] K. Xiao, A. Sohaib, P.-L. Sun, J. M. Yates, C. Li, and S. Wuerger, "A colour image reproduction framework for 3D colour printing," Proc. SPIE, vol. 10153, no. 2, 2016.

[2] K. Xiao, Y. Zhu, C. Li, D. Connah, J. M. Yates, and S. Wuerger, "Improved method for skin reflectance reconstruction from camera images," Opt. Express , vol. 24, no. 13, pp. 14934-14950, 2016

[3] K. Xiao, S. Wuerger, F. Mostafa, A. Sohaib, and J. M. Yates, "Colour Image Reproduction for 3D Printing Facial Prostheses," in New Trends in 3D Printing, 2016, pp. 89-109.

[4] K. Xiao et al., "Characterising the variations in ethnic skin colours: A new calibrated data base for human skin," Ski. Res. Technol., 2016.

[5] M. Wang, K. Xiao, M. R. Luo, M. Pointer, V. Cheung, and S. Wuerger, "An investigation into the variability of skin colour measurements," Color Res. Appl., 2018.

[6] A. Sohaib, K. Amano, K. Xiao, J. M. Yates, C. Whitford, and S. Wuerger, "Colour quality of facial prostheses in additive manufacturing," Int. J. Adv. Manuf. Technol., vol. 96, no. 1-4, 2018.

[7] Chauhan, T., Xiao, K., & Wuerger, S. (2019). Chromatic and luminance sensitivity for skin and skinlike textures. Journal of Vision, 19(1), 13. https://doi.org/10.1167/19.1.13



Data sets

Colorimetric (LAB) skin values for four ethnicities (Caucasian, Chinese, Kurdish, Thai): (download [link to https://pcwww.liv.ac.uk/~sophiew/data/skindatabaseLAB.zip]). Details in pub #4.
Database containing skin spectra (download [link to https://pcwww.liv.ac.uk/~sophiew/data/skindatabaseSpectra.zip]. Details in pub #2.

Full list on https://pcwww.liv.ac.uk/~sophiew/skin.htm
Exploitation Route We expect our findings to be used by 3DLifePrint, a company specialising in the additive manufacture of prosthetics. During the course of the this project, we have developed close contacts with 3DLifePrint who provide the interface to Alderhey Hospital (Liverpool) for us, hence facilitating impact in healthcare and the NHS and also consultants at the Head and Neck Cancer Centre at Liverpool. They are now in the process of setting up preclinical proof-of-concept trials for testing the new technology with a small set of patients.

Together with the Head and Neck Cancer Centre (Liverpool) we have applied for a HIP award and will also explore NIHR routes to make our findings useful for clinicians.
Sectors Digital/Communication/Information Technologies (including Software),Healthcare,Manufacturing, including Industrial Biotechology

URL https://pcwww.liv.ac.uk/~sophiew/skin.htm
 
Description Our findings are currently used by the Liverpool Head and Neck Cancer Centre to develop an NIHR application to translate our findings into clinical practice.
First Year Of Impact 2020
Sector Digital/Communication/Information Technologies (including Software),Healthcare,Manufacturing, including Industrial Biotechology
Impact Types Societal

 
Description EPSRC DTC Studentship on Additive Manufacturing
Amount £0 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 01/2019
 
Description EPSRC Impact Acceleration Account
Amount £22,000 (GBP)
Funding ID JXR12276 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2016 
End 03/2017
 
Title Spectral Reconstruction Algorithm 
Description We have developed a new algorithm to reconstruct the spectral reflectance distribution of human skin from a calibrated RGB camera image. This reconstruction method may be useful for many other healthcare applications, e.g. to diagnose diabetes, jaundice or other diseases that results in subtle skin tone changes 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2016 
Provided To Others? Yes  
Impact N/A 
 
Title A colorimetric comparison of sunless with natural skin tan 
Description Dataset for "A colorimetric comparison of sunless with natural skin tan".Kinjiro Amano, Kaida Xiao, Sophie Wuerger, Georg Meyer, PLoS One, 2020 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://figshare.com/articles/dataset/A_colorimetric_comparison_of_sunless_with_natural_skin_tan/132...
 
Title A colorimetric comparison of sunless with natural skin tan 
Description Dataset for "A colorimetric comparison of sunless with natural skin tan".Kinjiro Amano, Kaida Xiao, Sophie Wuerger, Georg Meyer, PLoS One, 2020 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://figshare.com/articles/dataset/A_colorimetric_comparison_of_sunless_with_natural_skin_tan/132...
 
Title A colorimetric comparison of sunless with natural skin tan 
Description Dataset for "A colorimetric comparison of sunless with natural skin tan".Kinjiro Amano, Kaida Xiao, Sophie Wuerger, Georg Meyer, PLoS One, Nov 2020;preprint on bioRxiv, Nov 2020:https://www.biorxiv.org/content/10.1101/2020.05.14.095778v2 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://figshare.manchester.ac.uk/articles/dataset/A_colorimetric_comparison_of_sunless_with_natural...
 
Title A colorimetric comparison of sunless with natural skin tan 
Description Dataset for "A colorimetric comparison of sunless with natural skin tan".Kinjiro Amano, Kaida Xiao, Sophie Wuerger, Georg Meyer, PLoS One, Nov 2020;preprint on bioRxiv, Nov 2020:https://www.biorxiv.org/content/10.1101/2020.05.14.095778v2 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://figshare.manchester.ac.uk/articles/dataset/A_colorimetric_comparison_of_sunless_with_natural...
 
Title CIE skin data base 
Description This is a data base containing camera images and spectral measurements of human facial skin. Skin colour measurements were performed on over 500 subjects in three countries with a view to establishing a new skin colour database and improving our understanding of skin colour in different racial populations. Measurements were obtained in the following groups: Caucasians-, Chinese-, and Kurdish population. Skin colour appearance, skin colour distribution, skin colour variation and skin colour boundaries were investigated, and quantitative comparisons between three ethnics groups were made. The results demonstrated that, in general, there was a clear trend for Chinese and Kurdish skin to be darker and more yellow when compared to Caucasian skin. However, large skin colour boundary overlaps were present, thus indicating that on some occasions differences in skin colour cannot easily be distinguished between the three ethnics groups. It was also found that compared to other ethnic groups, Caucasians has the largest variation in skin tones, whereas Chinese have the least skin colour variation. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Data collection is still ongoing. At the end it will be use by the CIE and made available to the general public. 
 
Title CIELAB skin data (colorimetric) 
Description This is a large data base (~1000) of skin measurements for four different ethnicities (Caucasian, Chinese, Thai, Kurdish). The colorimetric values are provided (LAB space) for each observer and for 9 different body locations 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact It will hopefully be used other researchers for modelling purposes. Our own research group has used it to evaluate the quality of 3D printed prosthethics (Amano et al, JoV 2017; draft available). 
URL http://pcwww.liv.ac.uk/~sophiew/data/skindatabaseLAB.zip
 
Title Data base for spectral measurements 
Description This is a data base containing the spectral measurements of a large skin sample, associated with the following publication: Improved method for skin reflectance reconstruction from camera images (Journal article) Xiao, K., Zhu, Y., Li, C., Connah, D., Yates, J. M., & Wuerger, S. (2016). Improved method for skin reflectance reconstruction from camera images. Optics Express, 24(13), 14934. doi:10.1364/OE.24.014934 DOI: 10.1364/OE.24.014934 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact we expect this data base in conjunction with the publication to be used for benchmarking. 
URL http://pcwww.liv.ac.uk/~sophiew/data/skindatabaseSpectra.zip
 
Description Further funding application 
Organisation 3D LifePrints
Country United Kingdom 
Sector Private 
PI Contribution We have now submitted an application to EPSRC on additive manufacture of 3D prostheses, with the aim of incorportating both the optical and biomechanical properties of skin in the printing process.
Collaborator Contribution Providing in-kind contribution of about 50K; expertise and access to state-of-the-art printers.
Impact Further funding application, together with Engineering and 3DLifePrints
Start Year 2015
 
Description New Collaboration with 3DLP 
Organisation 3D LifePrints
Country United Kingdom 
Sector Private 
PI Contribution We are currently co-supervising a Ph.D. students in the EPSRC DTC Advanced Manufacturing
Collaborator Contribution 3DLP is co-sponsoring a studentship (EPSRC DTC)
Impact This is a multi-disciplinary collaboration (3DLP; Engineering; Psychology; Medical School). Work going on as part of a Ph.D. and pilot data for new grant application.
Start Year 2016
 
Description Attendance at EPSRC-funded Viihm workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact We presented our work on skin appearance at an EPSRC-funded workshop [Chauhan, Wang, Yin, Xiao, Yates, Li & Wuerger (2014). Modelling Skin Appearance. Poster presented at the EPSRC workshop on Visual Image Interpretation in Humans and Machines (Viihm), Stratford-upon-Avon, Sep 24-25, 2014.].

As a result we have now submitted a proposal for funding for a specific workshop to explore possible applications of skin measurement in innovative healthcare technologies.
Year(s) Of Engagement Activity 2014
 
Description Invited talk on Skin Appearance and 3D printing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited paper on 'Skin appearance, measurement and 3D printing' at the 16th International Symposium on the Science and Technology of Lighting takes place on 17th - 22nd June 2018 in Sheffield, UK.
Year(s) Of Engagement Activity 2018
URL http://www.ls16.org/
 
Description Patient Work Groups - focus meetings in Manchester with potential beneficiaries (patients) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Patient focus group to understand the importance of the feel & look of facial prosthetics from the patients' view point.
Year(s) Of Engagement Activity 2018
 
Description Talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 2019 Lecture on 'Skin Appearance', European Training Network 'RealVision', Oxford.
Year(s) Of Engagement Activity 2020
 
Description Workshop with Industrial Stakeholders 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Business Gateway at the University of Liverpool organised a work shop with industrial stake holders (PZ cussons) to explore our capabilities at Liverpool for skin imaging and skin measurements. Our team was invited and we presented some of the outputs of the EPSRC award, i.e. data base and measurement techniques. As a consequence we will now be involved as co-applicants in a Knowledge Transfer Partnership with PZ Cussons.
Year(s) Of Engagement Activity 2018
 
Description media interest (skin project) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 2013-14 Various interviews with international radio and TV channels, e.g. Kurzweil; Premedia Broadcasting South Africa; polish and dutch radio channels.

After the various press releases numerous interviews were requested from media around the world. Several researches and health professionals indicate interest in further collaborations. These links are currently being pursued.

http://scienceofsingularity.com/tag/noses/; http://www.engineering.com/3DPrinting/3DPrintingArticles/ArticleID/6728/Natural-Looking-3D-Printed-Skin.aspx; http://phys.org/news/2013-11-natural-looking-3d-printed-skin.html; http://www.technology.org/2013/11/28/developing-convincing-3d-printed-skin/; etc.
Year(s) Of Engagement Activity 2014
URL http://www.technology.org/2013/11/28/developing-convincing-3d-printed-skin/