Kings College London - Equipment Account

Lead Research Organisation: King's College London
Department Name: UNLISTED

Abstract

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Description This Award has allowed to set-up an advanced Atomic Force Microscope coupled with a fluorescence Microscope. This unique combined instrumentation allows to mechanically perturb the sample (normally the surface of an individual cell) while observing the effects that the mechanical force has on the cell interior. In particular, this new instrumentation has provided the first measurements of the surprisingly fast force-activated translocation dynamics of mechanosensitive transcription factors from the cell cytoplasm to the nucleus.
Exploitation Route The Atomic Force Microscope system will be made available for use by the community on projects concerned with our understanding of the role of mechanical forces in cellular machinery, particularly through collaborations within King's College London and more widely in London, including researchers at the Francis Crick Institute.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology
 
Description H2020-FETPROACT-2016-2017 (FETPROACT-2016)
Amount € 7,134,929 (EUR)
Funding ID 731957 
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 01/2017 
End 01/2022
 
Description LINC-ing nanomechanics to gene expression: a single molecule approach
Amount £199,000 (GBP)
Funding ID RPG-2015-225 
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 02/2019
 
Description Mechanochemical biology: a force to be reckoned with
Amount £942,614 (GBP)
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2017 
End 11/2022