Smart Peripheral Stents for the Lower Extremity - Design, Manufacturing and Evaluation
Lead Research Organisation:
Manchester Metropolitan University
Department Name: School of Engineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Abdulsalam M
(2023)
In vitro study of the deployment performance of 3D printed stents in the diseased artery with the lipid arterial plaques
in Procedia Structural Integrity
Abdulsalam M
(2019)
Distinguish the Stable and Unstable Plaques Based on Arterial Waveform Analysis
in Procedia Structural Integrity
Abdulsalam M
(2022)
In vitro study of the deployment performance of 3D printed stents in the diseased artery with the lipid arterial plaques
in Procedia Structural Integrity
Abdulsalam M
(2021)
The composition of vulnerable plaque and its effect on arterial waveforms.
in Journal of the mechanical behavior of biomedical materials
Feng J
(2020)
Haemodynamic mechanism of formation and distribution of coronary atherosclerosis: A lesion-specific model.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Jamshidi P
(2022)
Development, characterisation, and modelling of processability of nitinol stents using laser powder bed fusion
in Journal of Alloys and Compounds
Kendall J
(2019)
In-vitro Study of Effect of the Design of the Stent on the Arterial Waveforms
in Procedia Structural Integrity
Wang D
(2021)
Numerical simulations of patient-specific models with multiple plaques in human peripheral artery: a fluid-structure interaction analysis.
in Biomechanics and modeling in mechanobiology
| Description | 1. In vitro study of the effect of design of stent on the arterial waveform propagation; The effect of the different design and material properties on the arterial waveform has been measured and analysed. The results demonstrate how the different design of stent has the effect on the blood wave propagation, providing the guidance for the design and material selection of the stent. 2. In-vitro artificial plaque model This model is used to study the haemodynamics performance of the stent when it is implemented in the different types of the diseased arterial system. The experimental test is under the way and is expected to obtain the results in April 2021 3, Fluid Structure Interaction Model for multiple arterial plaques (lipid core, calcified) FSI model for arterial-plaque-blood model can provide the patient-specified model for testing on the haemodynamics performance and mechanical performance of arterial wall when the stent is implemented. The simulation results have been published in August 2020. 4. FSI model for arterial-plaque-stent-blood model will be used to test the performance of stent and how the stent will have an effect of haemodynamic performance with the different types of plaques. 5. The effect of the compositions of the arterial plaque on the arterial waveform have been investigated in vitro study. The compositions of the arterial plaque, possessing the information of nature of the plaque, are to be obtained from the arterial waveform. The model is currently used for the effect of arterial plaque, combined with the different types of stents on the arterial waveform performance, 6. The FSI arterial plaque model (two types- lipid core and calcified) has been used for project partner for the design of personalized stents. |
| Exploitation Route | FSI model of artery-plaque-blood system can be used for the lesion-specific designed stent. FSI model also can be used to study the effect of individual plaque and multiple plaque on the haemodynamic performance in the upstream/downstream, hence, predicting on the plaque deformation and development. FSI model of artery-plaque-stent-blood system can be used for the lesion-specific designed stent. |
| Sectors | Healthcare |
| Description | The impact of this work is recorded against grant ref EP/R001650/1 |
| First Year Of Impact | 2019 |
| Sector | Healthcare |
| Title | Wave Intensity Analysis for the Effect of Stent on the Arterial Waveform |
| Description | The Non-invasive Wave Intensity Analysis is developed to analyze the effect of parameters of the stent on the arterial waveform. Through this methods, how the design of stent will affect the arterial waveform propagation in the arterial system is informed. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | This method is used to analyze the arterial waveform propagation in the carotid arteries and coronary arteries. This method is currently used to analyze the compositions of the carotid arterial plaques and aims to provide the important information to the vascular surgeons to stratify the carotid arterial diseases for the surgery. |
| Title | Fluid Structure Interaction (FSI) Peripheral Arterial Model |
| Description | Computational Fluid Dynamics (CFD) model and Finite Element (FE) model for the diseased peripheral arteries are built up based on CT images. This model will be used by the project team including the collaborators for the fluid domain and arterial wall interaction analysis. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This model will be used to analyze the deformation of arterial wall and haemodynamic performance of blood flow in the peripheral arteries. The effect of the stent on the haemodynamic performance and material behavior of the arterial wall will be assessed. |
| Description | Johnson Matthey |
| Organisation | Johnson Matthey |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Johnson Matthey is actively attending the project meeting. We have shared all of the documents including PPT to Johnson Matthey. Johnson Matthey is very interested in the evaluation method for the stent. |
| Collaborator Contribution | Johnson Matthey is interested in idea of manufacturing method for stent and submitted the patent application for a novel method of additive manufacturing of the stent. |
| Impact | Success this grant |
| Start Year | 2017 |
| Description | Manchester Royal Infirmary |
| Organisation | Manchester Royal Infirmary |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Our team has the expertise in the haemodynamics performance in the vascular/cardiovascular system which will benefit the surgery team to understand the blood flow performance in the diseased artery and effect of stents on the blood flow performance |
| Collaborator Contribution | Vascular Surgery Team has the expertise for the clinical applications of self-expanded stents in the vascular system |
| Impact | We have collaborated together and successfully the grant application in GMAHSN and one in EPSRC. Recently we have submitted one application to EPSRC. |
| Start Year | 2015 |
| Description | Department of Engineering_Research Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The research methods and findings were presented to Biomedical engineering seminar organized by Department of Engineering. The participants were mainly from Faculty of Science and Engineering in Manchester Metropolitan University. The aim of this activity is to develop a new undergraduate Biomedical Engineering programme. The presentation attracted a lot of attention and sparked questions and discussions afterwards. |
| Year(s) Of Engagement Activity | 2020 |
| Description | ESVS Conference |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This activity aims to develop the collaboration with clinicians. The research findings and methods attracted the attention from the cardiovascular/vascular surgeons, which sparked immediate collaboration request from other participants. |
| Year(s) Of Engagement Activity | 2019 |
| Description | International conference for stent |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Research team attended this conference which attracted approximately 70 participants who are interested in the stent design. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Virtual International Conference |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The research findings have been recorded and uploaded to conference website and also presented in the virtual conference. The presentation attracted an attention. Afterwards authors are invited to present the results to peer reviewed journal. |
| Year(s) Of Engagement Activity | 2020 |