Smartwound-plasma
Lead Research Organisation:
Lancaster University
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Gaur N
(2023)
On Plasma Fractionation Treatment and Its Implications in Cells
in IEEE Transactions on Radiation and Plasma Medical Sciences
Ghimire B
(2021)
Enhancement of hydrogen peroxide production from an atmospheric pressure argon plasma jet and implications to the antibacterial activity of plasma activated water
in Plasma Sources Science and Technology
Ghimire B
(2021)
The influence of a second ground electrode on hydrogen peroxide production from an atmospheric pressure argon plasma jet and correlation to antibacterial efficacy and mammalian cell cytotoxicity
in Journal of Physics D: Applied Physics
Ghimire B
(2022)
A conical assembly of six plasma jets for biomedical applications
in Applied Physics Letters
Hathaway H
(2019)
Delivery and quantification of hydrogen peroxide generated via cold atmospheric pressure plasma through biological material
in Journal of Physics D: Applied Physics
Patenall BL
(2019)
Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition.
in Chemical communications (Cambridge, England)
Patenall BL
(2021)
Assessment of mutations induced by cold atmospheric plasma jet treatment relative to known mutagens in Escherichia coli.
in Mutagenesis
Szili E
(2021)
On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
in Applied Physics Letters
Williams GT
(2020)
Boronate ester cross-linked PVA hydrogels for the capture and H2O2-mediated release of active fluorophores.
in Chemical communications (Cambridge, England)
| Description | We have successfully re-engineered the plasma jet to deliver therapeutically useful doses of hydrogen peroxide within clinical acceptable treatment times (< 5 mins). This has resulted in a number of new jet design features that have been patented ("Plasma Device" 20589P/WO). We have shown release of a series of potent antimicrobial agents from a hydrogel dressing - this agent effectively produces log 6 reduction in planktonic micro-organisms. We have incorporated the design features from 20589P/WO into a multi-jet plasma source that can deliver significantly higher concentrations of hydrogen peroxide and can be operated with an anti-microbial loaded plasma screen across a large area wound. This work laid the basis for a joint patent (Bath and Lancaster Universities), which has been further developed under the award EPV00607X1. The patent will be filed in February 2022. |
| Exploitation Route | Findings are providing the basis for a potential non-antibiotic approach to infected DFUs |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Results support the Lancaster University spin-out company Plasma4 |
| First Year Of Impact | 2021 |
| Sector | Healthcare |
| Impact Types | Economic |
| Description | Plasma-activated hydrogel therapy (PAHT) for combatting infections in DFUs |
| Amount | £714,912 (GBP) |
| Funding ID | EPV00607X1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2024 |
| Title | Plasma Device |
| Description | The present invention relates to a plasma device and method for the generation of hydrogen peroxide. There is also provided a plasma treatment method for a patient in need thereof including activating a hydrogel through contact with a plasma including hydrogen peroxide to release therapeutic agents from the hydrogel dressing. There is also provided a method of deactivation of micro-organisms (bacteria and viruses) on surfaces/materials that are thermally sensitive. In such embodiments, the plasma including hydrogen peroxide may be used to decontaminate or treat surfaces directly |
| IP Reference | 20589P/WO |
| Protection | Patent application published |
| Year Protection Granted | |
| Licensed | No |
| Impact | n/a yet |
| Company Name | PLASMA4 LIMITED |
| Description | Developing plasma technology for medical applications. |
| Year Established | 2021 |
| Impact | N/a |
| Website | https://www.plasma-4.com |