Underpinning Mechanistic Studies of NHC-Organocatalysis: A Breslow Intermediate Reactivity Scale
Lead Research Organisation:
University of St Andrews
Department Name: Chemistry
Abstract
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Organisations
Publications
Abdelhamid Y
(2022)
Isothiourea-Catalyzed [2 + 2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins.
in Organic letters
Collett C
(2021)
Kinetic and Structure-Activity Studies of the Triazolium Ion- Catalyzed Intramolecular Stetter Reaction
in European Journal of Organic Chemistry
Duan Z
(2022)
Rate and equilibrium constants for the addition of triazolium salt derived N-heterocyclic carbenes to heteroaromatic aldehydes.
in Chemical science
Nimmo AJ
(2023)
Enantioselective isothiourea-catalysed reversible Michael addition of aryl esters to 2-benzylidene malononitriles.
in Chemical science
Wang Y
(2022)
A Desilylative Approach to Alkyl Substituted C(1)-Ammonium Enolates: Application in Enantioselective [2+2] Cycloadditions
in Angewandte Chemie International Edition
Wang Y
(2023)
Probing Regio- and Enantioselectivity in the Formal [2 + 2] Cycloaddition of C(1)-Alkyl Ammonium Enolates with ß- and a,ß-Substituted Trifluoromethylenones.
in The Journal of organic chemistry
Zhu J
(2022)
The Role of the Fused Ring in Bicyclic Triazolium Organocatalysts: Kinetic, X-ray, and DFT Insights.
in The Journal of organic chemistry
| Description | We have worked towards an understanding of a number of common reaction processes that use reactive organic compounds known as NHCs and demonstrated their utility in understanding reaction mechanisms. |
| Exploitation Route | The understanding generated will be of widespread use within the synthesis and caltaysis communities, and may translate to large scale applications. IN particular, the understanding generated in this work will be able to be understood and applied by others leading to new reactivity. |
| Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |