Water exchange in the vasculature of the brain (WEX-BRAIN)
Lead Research Organisation:
Lancaster University
Department Name: Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Hedley Emsley (Principal Investigator) |
Publications
Al-Bachari S
(2020)
Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.
in Frontiers in physiology
| Description | Influence of WEX-BRAIN on clinical and research practice in SVD in the North West of England |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Contribution to new or improved professional practice |
| Impact | Training impacts already realised We would anticipate potential changes to clinical and research practice in SVD to be realised over time |
| Description | Neurology Research Fellow |
| Amount | £178,000 (GBP) |
| Organisation | Lancashire Teaching Hospitals NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 07/2024 |
| Description | North West of England collaboration on cerebral small vessel disease. |
| Organisation | Salford Royal NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | WEX-BRAIN has catalysed a new collaboration on small vessel disease between the neuroscience centres in Lancashire and Greater Manchester. The addition of Salford Royal NHS Foundation Trust as a recruitment centre has led to joint working between Dr Sen (Greater Manchester), Prof Emsley (Lancashire Teaching Hospitals NHS Foundation Trust & Lancaster University) and Dr Maskery (Clinical Research Fellow, Lancaster University) on patient recruitment and SVD clinic collaboration. Collaborative abstracts describing SVD clinical services and burden have been submitted to the UK Association of British Neurologists Meeting 2023 and to the European Stroke Organisation Conference 2023. |
| Collaborator Contribution | Identification of research participants for the clinical WEX-BRAIN study New collaborative academic partnership Training opportunity through attendance of clinical research fellow at a dedicated SVD clinic in Manchester |
| Impact | Collaborative abstracts describing SVD clinical services and burden have been submitted to the UK Association of British Neurologists Meeting 2023 and to the European Stroke Organisation Conference 2023. |
| Start Year | 2022 |
| Description | Lancaster Medical School research strategy event |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Around 40 attendees at an event to discuss Lancaster Medical School research strategy and the interface with regional NHS organisations. The attendees were drawn from a very mixed professional background linked to medical research and healthcare delivery, comprising a few clinicians, quite a few regional research directors/heads of R&D, senior research nurses, middle ranking and senior NHS managers and a couple of non-clinical university academics 10:00 Introduction 10:05 Opening remarks from Chief Executive of Lancashire Teaching Hospitals NHS Foundation Trust 10:10 A series of short presentations from Hedley Emsley and colleagues on examples of how clinical neuroscience research is facilitated in the region. This included a presentation from the clinical research fellow (and current PhD student) working on the WEX-BRAIN clinical study. 10:55 Comfort break 11:05 Q&A, discussion and idea sharing, to include: The long term strategic aims/desired outcomes of partnering across the region to facilitate clinical Neuroscience research What will enable us to engage and be successful? Next steps/quick wins? Please come to the day ready to share your thoughts on the above. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation of WEX-BRAIN clinical study at Lancashire Neuroscience events |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lancashire Neuroscience is a website and regional forum for individuals engaged in neuroscience research within Lancashire. It seeks to promote neuroscience research in Lancashire as well as achieving improved visibility of neuroscience research activity in Lancashire - to researchers and non-researchers within Lancashire and elsewhere, improved opportunities for collaboration between researchers through increased awareness / networking, enablement of greater patient and public participation, and increased opportunities for investment and enterprise through partnership and collaboration. Periodic meetings are held between professional practitioners; the WEX-BRAIN clinical study has been presented at one of these meeting, as well as featuring on the Lancashire Neuroscience website where it can be openly viewed. |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://www.lancashireneuroscience.co.uk/research/clinical-neuroimaging-studies |
| Description | Presentation of WEX-BRAIN clinical study to NHS clinical stroke team |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation by Dr Mark Maskery (Clinical Research Fellow and PhD student working on the WEX-BRAIN clinical study) to the Lancashire Teaching Hospitals NHS Foundation Trust clinical stroke team. This was a presentation that Mark gave on 8/10/21 to describe the study, its background, aims, methods, participants, and his request for assistance with identification of participants and their recruitment. The audience included 3-4 stroke research nurses (based at the NIHR Lancashire Clinical Research Facility and supported by the North West Coast NIHR Clinical Research Network, as WEX-BRAIN is an NIHR portfolio study), 2 consultant stroke physicians, a registrar working in stroke and 4-5 other junior doctors. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Update on SVD research in Lancashire |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation to preclinical and clinical academic audience at a regional forum, with international representation (including visiting academics from a North American institute), on SVD. This was an update on SVD research activity in Lancashire, including WEX-BRAIN. |
| Year(s) Of Engagement Activity | 2023 |