Edinburgh Centre for Advanced Multi-Elemental Analysis (AMEA)
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
Our current facility has two instruments that determine the concentration of a range of elements in aqueous and organic solutions. These are (i) a recently purchased Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES); and (ii) a 13-year-old Inductively Coupled Plasma-Single Quadrupole-Mass Spectrometer (ICP-Q-MS). These instruments have in common an "inductively coupled plasma" which acts like a very high temperature 'flame' and transforms elements in the sample solution into atoms or ions which can be detected spectroscopically (either by emission spectrum (OES) or by mass-to-charge ratio (MS)) and then quantified by comparing the detector signal to that from standard solutions.
We require new instruments because the current ICP-Q-MS cannot be repaired and so when it breaks down it will have to be decommissioned. This would mean that several of our ongoing research and consultancy projects could not be completed without resorting to expensive analysis at external organisations or commercial laboratories.
We now require more advanced instruments because our well-established user community have continually evolving research goals and we are currently working at the limits of what the existing instruments can achieve. In particular, we need to be able to make reliable measurements of elements present at extremely low concentrations (for example, 1 in a trillion to 1 in a quadrillion) in a much wider range of sample types (for example, solutions which contain relatively large amounts of salts or organic compounds). Currently, these types of solution would cause our ICP-Q-MS to become less sensitive and would also damage parts of the instrument including the detector. The new ICP-Q-MS instruments get around this problem by using argon gas to dilute the sample solutions before they enter the detector and so sensitivity loss does not occur. These new generation instruments are also much easier to operate and we will be able to train researchers to set up and run not only our existing ICP-OES but the new ICP-Q-MS. We will provide advice about which instrument would be best for determining the concentrations of the range of elements in their samples, e.g. mid-to-high level will be best on the former.
Our users also want to analyse a wider range of elements and we are currently restricted because there are interferences (detector signals that coincide with the element that we want to measure) that can't be removed either using the ICP-OES or ICP-Q-MS. For example, elements such as phosphorus and sulfur are present at extremely low levels in biological samples and sulfur is also present in the new biofuels that are being developed to replace diesel. A much more complex "interference removal" process is required before the concentrations of these elements can be accurately determined. This is achieved by using a combination of a first detector, a reaction cell and then a second detector in an ICP instrument called a "triple quadrupole" (ICP-QQQ-MS). A highly skilled operator will help researchers to identify and eliminate the signals which are coming from other components of their samples. Other elements such as vanadium (for use in new batteries) and the rare earth elements (for use in computers, cameras, cars and aircraft etc.) will also be much easier to measure as we support research into sustainable methods for recovering these important resources.
Finally, we need to make some adjustments to the rooms that will accommodate the new instruments. We want to make two smaller rooms into one larger one that will allow us to have three instruments (ICP-OES, ICP-Q-MS and ICP-QQQ-MS) in a single location, the Edinburgh Centre for Advanced Multi-Elemental Analysis (AMEA), supported by our research technician, Dr. Lorna Eades. An upgraded air conditioning system and an additional/upgraded exhaust gas extraction system will lower dust and noise levels.
We require new instruments because the current ICP-Q-MS cannot be repaired and so when it breaks down it will have to be decommissioned. This would mean that several of our ongoing research and consultancy projects could not be completed without resorting to expensive analysis at external organisations or commercial laboratories.
We now require more advanced instruments because our well-established user community have continually evolving research goals and we are currently working at the limits of what the existing instruments can achieve. In particular, we need to be able to make reliable measurements of elements present at extremely low concentrations (for example, 1 in a trillion to 1 in a quadrillion) in a much wider range of sample types (for example, solutions which contain relatively large amounts of salts or organic compounds). Currently, these types of solution would cause our ICP-Q-MS to become less sensitive and would also damage parts of the instrument including the detector. The new ICP-Q-MS instruments get around this problem by using argon gas to dilute the sample solutions before they enter the detector and so sensitivity loss does not occur. These new generation instruments are also much easier to operate and we will be able to train researchers to set up and run not only our existing ICP-OES but the new ICP-Q-MS. We will provide advice about which instrument would be best for determining the concentrations of the range of elements in their samples, e.g. mid-to-high level will be best on the former.
Our users also want to analyse a wider range of elements and we are currently restricted because there are interferences (detector signals that coincide with the element that we want to measure) that can't be removed either using the ICP-OES or ICP-Q-MS. For example, elements such as phosphorus and sulfur are present at extremely low levels in biological samples and sulfur is also present in the new biofuels that are being developed to replace diesel. A much more complex "interference removal" process is required before the concentrations of these elements can be accurately determined. This is achieved by using a combination of a first detector, a reaction cell and then a second detector in an ICP instrument called a "triple quadrupole" (ICP-QQQ-MS). A highly skilled operator will help researchers to identify and eliminate the signals which are coming from other components of their samples. Other elements such as vanadium (for use in new batteries) and the rare earth elements (for use in computers, cameras, cars and aircraft etc.) will also be much easier to measure as we support research into sustainable methods for recovering these important resources.
Finally, we need to make some adjustments to the rooms that will accommodate the new instruments. We want to make two smaller rooms into one larger one that will allow us to have three instruments (ICP-OES, ICP-Q-MS and ICP-QQQ-MS) in a single location, the Edinburgh Centre for Advanced Multi-Elemental Analysis (AMEA), supported by our research technician, Dr. Lorna Eades. An upgraded air conditioning system and an additional/upgraded exhaust gas extraction system will lower dust and noise levels.
Planned Impact
The new AMEA centre will provide the high-end underpinning elemental analysis that is required to benefit academics, including new and more experienced researchers, working across a broad range of disciplines on EPSRC-relevant research topics that will have wide socio-economic and environmental benefit. This includes new: (i) nanomaterials for enhanced drug delivery; (ii) energy storage materials to enable renewable energy resources to address security of supply issues; (iii) photocatalysts for development of low-cost sustainable treatments to generate clean water suitable for human consumption in developing countries.
Through Edinburgh Innovations Limited (EI), the commercialisation arm of the University of Edinburgh, we regularly engage with a wide range of companies who choose to work with us because of our problem-solving as well as technological capabilities. The new instrumentation will enable us to offer enhanced scope for projects, e.g. wider range of elements at extremely low (ppt-ppq level) to very high (ppm-ppth level) in a broader range of sample types. In this way, we will be able to support a wider range of industrial applications, e.g. in oil and gas decommissioning, scale-up and commercialisation of energy storage devices, development of diesel-replacement fuels etc. Two letters of support from industrial partners, SUNAMP and Infineum, are included.
We will offer training for young researchers to equip them with the knowledge and skills to become leading scientists and generate high impact research outputs. We already have a strong track record in providing the elemental analysis that has been included in papers published in Nature, Angewandte Chemie, Chemical Science. Several of these publications have also attracted significant media attention and we will work with the Impact Champion in the School of Chemistry to promote exciting new developments achieved by AMEA-centre users.
We have proposed two workshops (October 2020, March 2021) to which all internal and external users, both academic and industrial users will be invited to explore the potential of the new instrumentation to meet their research goals. We will also hold a launch event which will link to an annual ICP users meeting (scheduled for November 2020) and this will provide an additional opportunity to engage with a wide range of users.
Finally, Eades, the Centre Manager, regularly engages with school children and the general public through outreach events. We propose to participate in the Edinburgh Science Festival, using tactile sculptures, e.g. a fused glass artistic representation of how the ICP instrument works, as a means of communicating the technology to the wider public and using accompanying posters to show how the measurements made in the AMEA centre are crucially important in helping scientists to meet EPSRC-relevant current and future research challenges such as developing new materials.
Through Edinburgh Innovations Limited (EI), the commercialisation arm of the University of Edinburgh, we regularly engage with a wide range of companies who choose to work with us because of our problem-solving as well as technological capabilities. The new instrumentation will enable us to offer enhanced scope for projects, e.g. wider range of elements at extremely low (ppt-ppq level) to very high (ppm-ppth level) in a broader range of sample types. In this way, we will be able to support a wider range of industrial applications, e.g. in oil and gas decommissioning, scale-up and commercialisation of energy storage devices, development of diesel-replacement fuels etc. Two letters of support from industrial partners, SUNAMP and Infineum, are included.
We will offer training for young researchers to equip them with the knowledge and skills to become leading scientists and generate high impact research outputs. We already have a strong track record in providing the elemental analysis that has been included in papers published in Nature, Angewandte Chemie, Chemical Science. Several of these publications have also attracted significant media attention and we will work with the Impact Champion in the School of Chemistry to promote exciting new developments achieved by AMEA-centre users.
We have proposed two workshops (October 2020, March 2021) to which all internal and external users, both academic and industrial users will be invited to explore the potential of the new instrumentation to meet their research goals. We will also hold a launch event which will link to an annual ICP users meeting (scheduled for November 2020) and this will provide an additional opportunity to engage with a wide range of users.
Finally, Eades, the Centre Manager, regularly engages with school children and the general public through outreach events. We propose to participate in the Edinburgh Science Festival, using tactile sculptures, e.g. a fused glass artistic representation of how the ICP instrument works, as a means of communicating the technology to the wider public and using accompanying posters to show how the measurements made in the AMEA centre are crucially important in helping scientists to meet EPSRC-relevant current and future research challenges such as developing new materials.
Organisations
People |
ORCID iD |
| Andrew Mount (Principal Investigator) |