Computational Biomedicine at the Exascale
Lead Research Organisation:
University of Oxford
Department Name: Computer Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Berg L
(2023)
Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks
in Scientific Reports
Camps J
(2025)
Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing.
in Medical image analysis
Coleman J
(2024)
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
in Frontiers in Pharmacology
Dasà A
(2024)
Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion.
in The Journal of physiology
Lawson B
(2024)
Perlin noise generation of physiologically realistic cardiac fibrosis
in Medical Image Analysis
Li L
(2025)
Personalized topology-informed localization of standard 12-lead ECG electrode placement from incomplete cardiac MRIs for efficient cardiac digital twins
in Medical Image Analysis
Martinez-Navarro H
(2024)
ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location.
in Frontiers in cardiovascular medicine
Sayers J
(2025)
Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction
in Nature Cardiovascular Research
| Description | We have demonstrated the utility of high performance computing to evaluate the safety and efficacy of medical therapies using multiscale modelling and simulation. |
| Exploitation Route | We are making all publications and software open access, and we are training students and researchers in Computational Medicine. |
| Sectors | Digital/Communication/Information Technologies (including Software) Healthcare Pharmaceuticals and Medical Biotechnology |
| URL | https://scholar.google.com/citations?user=qYidL6sAAAAJ&hl=en |
| Description | AstraZeneca |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | we have engaged in a collaboration to develop novel approaches for the delivery and evaluation of the safety and efficacy of cell therapy to the heart. |
| Collaborator Contribution | They have awarded a CASE studentship and are sharing data. |
| Impact | We still don't have outputs as the collaboration just started. |
| Start Year | 2020 |
| Description | AstraZeneca |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | we have engaged in a collaboration to develop novel approaches for the delivery and evaluation of the safety and efficacy of cell therapy to the heart. |
| Collaborator Contribution | They have awarded a CASE studentship and are sharing data. |
| Impact | We still don't have outputs as the collaboration just started. |
| Start Year | 2020 |
| Description | Federal University of Juiz de Fora |
| Organisation | Federal University of Juiz de Fora |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Provided requirements and conducted high performance computing simulations for the development of open source software for cardiac modelling and simulations. |
| Collaborator Contribution | Developed code for cardiac modelling and simulaion |
| Impact | Papers are in progress |
| Start Year | 2023 |
| Description | Cardiac Physiome conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | international audience in cardiac research including experimentalists, clinicians and computational scientists. |
| Year(s) Of Engagement Activity | 2024 |
| Description | ESC 2025 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at the European Society of Cardiology Congress (available online) |
| Year(s) Of Engagement Activity | 2024 |