New strategies to produce perfluorinated radiotracers for PET imaging
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: Chemistry
Abstract
Positron Emission Tomography (PET) imaging is a molecular imaging technique that can provide quantitative data on biological processes in the human body and is widely used by healthcare providers, pharmaceutical companies, and academic researchers. The PET radionuclide fluorine-18 is has many advantageous properties for the radiolabelling of small molecule PET radiotracers. Currently, the range and diversity of small molecules that can be radiolabelled are limited by the radiochemistry methods available. This fellowship will expand the toolkit of reactions available to includes 18F-perfluorinated motifs, and consequently, the range and
breadth of 18F-radiotracers through an oxidative fluorination strategy. Using this new method, we will develop syntheses of 18F-Gemcitabine and 18F-EF5, two highly sought after targets currently inaccessible from [18F]fluoride. This fellowship is highly interdisciplinary and will provide expert training in fluorine (radio)chemistry, automation, Good Manufacturing Practice and clinical translation.
breadth of 18F-radiotracers through an oxidative fluorination strategy. Using this new method, we will develop syntheses of 18F-Gemcitabine and 18F-EF5, two highly sought after targets currently inaccessible from [18F]fluoride. This fellowship is highly interdisciplinary and will provide expert training in fluorine (radio)chemistry, automation, Good Manufacturing Practice and clinical translation.
Organisations
| Description | A novel method has been developed to access polyfluorinated 18F-radiotracers commonly used as diagnostic tools for biomedical research and in the clinic for patient health. The technology developed has expanded the radiochemical space in which we can design novel diagnostic agents and will allow for the development of previously inaccessible 18F-radiotracers. |
| Exploitation Route | Biomedical researchers and pharmaceutical companies in the design and synthesise of radiotracers. |
| Sectors | Chemicals Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | International Fluorine Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Personal invitation to speak on research from this grant at the 23rd International Fluorine Symposium in Quebec City, Canada. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://isfc2023.org/ |
| Description | Invited speaker at the Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden - Riossendorf, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Personal invitation to present research at Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden - Riossendorf, Germany |
| Year(s) Of Engagement Activity | 2024 |
| Description | Royal Society of Chemistry Fluorine Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invitation to give plenary lecture at the annual Royal Society of Chemistry Fluorine subject meeting. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Virtual presentation at NIH Bethesda USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Personal invitation to present research at at NIH Bethesda USA |
| Year(s) Of Engagement Activity | 2024 |