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MultiSMART: Multi-component Soft Materials Advanced Research Training Network

Lead Research Organisation: University of York
Department Name: Chemistry

Abstract

MultiSMART, Multi-component Soft Materials Advanced Research Training Network, is a Doctoral Network of six Universities, one
private nonprofit Research Institute, two large Companies and an SME, involving training, fundamental research and applications in
the field of molecular soft materials. These have substantial societal and economic impact, but require innovation to ensure
sustainable development. The primary research objectives are defined as (i) the innovation in soft materials through multicomponent
self-assemblies; (ii) the application of these materials in the formulation of actives with elevated performance in the largescale
industries of personal care and home care, as well as high-added value regenerative therapies. Multi-component systems based
on low molecular weight gelators have considerable potential to achieve these goals with the key advantages of programmability
and responsiveness. However, their development hinges upon the formation of an inter-disciplinary network with well-trained
researchers.
MultiSMART proposes: (1) the training of the future generation of researchers; (2) the tight integration between academic projects
and private sector needs; (3) a network-wide, seamless multidisciplinary, international and inter-sectoral training that is not available
at any one institution. MultiSMART will be formed around 9 hired researchers who will have the opportunity to become scientists
employable in both the industrial and academic sectors. In an integrated approach, they will be trained to bridge the gap between
chemistry, physics, biology and formulation technology, as well as to acquire transferable skills through their research and specifically
designed network-wide schools and workshops. The participation of three industrial participants in research and training
programmes will guarantee extensive inter-sectoral experience for the trainees and maximise the impact of the network.

Publications

10 25 50
 
Description One of the key objectives on this cross-European Network grant was to synthesis a gelator system and demonstrate its potential for drug formulation and delivery. We have developed a new system which forms self-healing gels, suitable for spraying or dropping in liquid form and then subsequently setting into a gel. We loaded this gel with the drug atropine (for treatment of myopia) and demonstrated that effective release of the drug from the gel could be achieved at doses and timescales suitable for use in delivery to the eye. All of the studies so far were performed in vitro. We will move on to study the system in vivo in due course.

Furthermore, having worked on one gel system which we published (Chemistry A European Journal), we went on to optimise the gel to lower its toxicity, while retaining all of its beneficial performance. We are currently preparing a patent to protect this unpublished optimised system.
Exploitation Route We would hope this gel may be applied by pharmaceutical companies and used as a delivery vehicle for a variety of drugs via (for example) ocular, nasal, or subcutaneous injection delivery routes.
Sectors Healthcare

Pharmaceuticals and Medical Biotechnology

 
Description Acylhydrazide gelators for pharmaceutical crystallisation 
Organisation Durham University
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of gelator for testing
Collaborator Contribution Testing of pharmaceutical crystallisation in hydrogels
Impact This has been a very positive collaboration which has yielded interesting results. Our partner (in collaboration with us) is currently in the process of preparing a high-impact paper that includes results from this collaboration.
Start Year 2024
 
Description Characterisation of Supramolecular Gels Using Scattering Methods 
Organisation University of Stuttgart
Country Germany 
Sector Academic/University 
PI Contribution We synthesised the materials being studied by scattering methods
Collaborator Contribution They are performign X-ray and neutron scattering analysis to provide detailed structural insight into the self-assembly of our hydrogels.
Impact No outputs as yet. The collaboration is multi-disciplinary with physics.
Start Year 2025
 
Description Fabrication of Gel-Surfactant Hybrid Materials 
Organisation University of Stuttgart
Country Germany 
Sector Academic/University 
PI Contribution Provision of gelator molecules to develop hybrid soft materials
Collaborator Contribution Fabrication and testing of hybrid soft materials
Impact No outputs yet
Start Year 2023
 
Description New Gelators for Nasal Drug Delivery 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of self-healing gels for testing in nasal delivery
Collaborator Contribution Animal model studies to explore brain uptake of gels and active pharmaceuticals via the nasal route
Impact No outputs yet associated with this project (there are outputs previously from this collaboration but associated with different funders)
Start Year 2024
 
Description York Festival of Ideas - Public Engagement (Exhibition) - THE POWER OF GELS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was an exhibition in a York library designed to showcase cutting edge research. The team presented a series of gels, and their impacts in next generation technologies. The exhibit was particularly popular with families and children aged 7-14.
Year(s) Of Engagement Activity 2024
URL https://yorkfestivalofideas.com/