MultiSMART: Multi-component Soft Materials Advanced Research Training Network
Lead Research Organisation:
University of York
Department Name: Chemistry
Abstract
MultiSMART, Multi-component Soft Materials Advanced Research Training Network, is a Doctoral Network of six Universities, one
private nonprofit Research Institute, two large Companies and an SME, involving training, fundamental research and applications in
the field of molecular soft materials. These have substantial societal and economic impact, but require innovation to ensure
sustainable development. The primary research objectives are defined as (i) the innovation in soft materials through multicomponent
self-assemblies; (ii) the application of these materials in the formulation of actives with elevated performance in the largescale
industries of personal care and home care, as well as high-added value regenerative therapies. Multi-component systems based
on low molecular weight gelators have considerable potential to achieve these goals with the key advantages of programmability
and responsiveness. However, their development hinges upon the formation of an inter-disciplinary network with well-trained
researchers.
MultiSMART proposes: (1) the training of the future generation of researchers; (2) the tight integration between academic projects
and private sector needs; (3) a network-wide, seamless multidisciplinary, international and inter-sectoral training that is not available
at any one institution. MultiSMART will be formed around 9 hired researchers who will have the opportunity to become scientists
employable in both the industrial and academic sectors. In an integrated approach, they will be trained to bridge the gap between
chemistry, physics, biology and formulation technology, as well as to acquire transferable skills through their research and specifically
designed network-wide schools and workshops. The participation of three industrial participants in research and training
programmes will guarantee extensive inter-sectoral experience for the trainees and maximise the impact of the network.
private nonprofit Research Institute, two large Companies and an SME, involving training, fundamental research and applications in
the field of molecular soft materials. These have substantial societal and economic impact, but require innovation to ensure
sustainable development. The primary research objectives are defined as (i) the innovation in soft materials through multicomponent
self-assemblies; (ii) the application of these materials in the formulation of actives with elevated performance in the largescale
industries of personal care and home care, as well as high-added value regenerative therapies. Multi-component systems based
on low molecular weight gelators have considerable potential to achieve these goals with the key advantages of programmability
and responsiveness. However, their development hinges upon the formation of an inter-disciplinary network with well-trained
researchers.
MultiSMART proposes: (1) the training of the future generation of researchers; (2) the tight integration between academic projects
and private sector needs; (3) a network-wide, seamless multidisciplinary, international and inter-sectoral training that is not available
at any one institution. MultiSMART will be formed around 9 hired researchers who will have the opportunity to become scientists
employable in both the industrial and academic sectors. In an integrated approach, they will be trained to bridge the gap between
chemistry, physics, biology and formulation technology, as well as to acquire transferable skills through their research and specifically
designed network-wide schools and workshops. The participation of three industrial participants in research and training
programmes will guarantee extensive inter-sectoral experience for the trainees and maximise the impact of the network.
People |
ORCID iD |
| David Smith (Principal Investigator) |
Publications
El-Qarra L
(2024)
Formulation and Release of Active Pharmaceutical Ingredients Using a Supramolecular Self-Healing Two-Component Gel
in Chemistry - A European Journal
Smith DK
(2023)
Supramolecular gels - a panorama of low-molecular-weight gelators from ancient origins to next-generation technologies.
in Soft matter
| Description | One of the key objectives on this cross-European Network grant was to synthesis a gelator system and demonstrate its potential for drug formulation and delivery. We have developed a new system which forms self-healing gels, suitable for spraying or dropping in liquid form and then subsequently setting into a gel. We loaded this gel with the drug atropine (for treatment of myopia) and demonstrated that effective release of the drug from the gel could be achieved at doses and timescales suitable for use in delivery to the eye. All of the studies so far were performed in vitro. We will move on to study the system in vivo in due course. Furthermore, having worked on one gel system which we published (Chemistry A European Journal), we went on to optimise the gel to lower its toxicity, while retaining all of its beneficial performance. We are currently preparing a patent to protect this unpublished optimised system. |
| Exploitation Route | We would hope this gel may be applied by pharmaceutical companies and used as a delivery vehicle for a variety of drugs via (for example) ocular, nasal, or subcutaneous injection delivery routes. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Acylhydrazide gelators for pharmaceutical crystallisation |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of gelator for testing |
| Collaborator Contribution | Testing of pharmaceutical crystallisation in hydrogels |
| Impact | This has been a very positive collaboration which has yielded interesting results. Our partner (in collaboration with us) is currently in the process of preparing a high-impact paper that includes results from this collaboration. |
| Start Year | 2024 |
| Description | Characterisation of Supramolecular Gels Using Scattering Methods |
| Organisation | University of Stuttgart |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We synthesised the materials being studied by scattering methods |
| Collaborator Contribution | They are performign X-ray and neutron scattering analysis to provide detailed structural insight into the self-assembly of our hydrogels. |
| Impact | No outputs as yet. The collaboration is multi-disciplinary with physics. |
| Start Year | 2025 |
| Description | Fabrication of Gel-Surfactant Hybrid Materials |
| Organisation | University of Stuttgart |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Provision of gelator molecules to develop hybrid soft materials |
| Collaborator Contribution | Fabrication and testing of hybrid soft materials |
| Impact | No outputs yet |
| Start Year | 2023 |
| Description | New Gelators for Nasal Drug Delivery |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of self-healing gels for testing in nasal delivery |
| Collaborator Contribution | Animal model studies to explore brain uptake of gels and active pharmaceuticals via the nasal route |
| Impact | No outputs yet associated with this project (there are outputs previously from this collaboration but associated with different funders) |
| Start Year | 2024 |
| Description | York Festival of Ideas - Public Engagement (Exhibition) - THE POWER OF GELS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an exhibition in a York library designed to showcase cutting edge research. The team presented a series of gels, and their impacts in next generation technologies. The exhibit was particularly popular with families and children aged 7-14. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://yorkfestivalofideas.com/ |