Novel Functional Nanocomposite Engineering of Stents
Lead Research Organisation:
University of Manchester
Department Name: Physics and Astronomy
Abstract
We propose a four-party collaborative research programme that combines the expertise of the materials science, engineering, and surface science and cell biology from four leading universities. We wish to continue our highly successful Flagship Grant programme in the development of Abdominal Aortic Aneurysm (AAA) stent graft and coronary stent whereby stainless steel and shape memory alloy (SMA) are coated with nanocomposite (NC) polymer. Our preliminary work has demonstrated excellent blood and tissue biocompatibility and we have attributed this property to the preferential adsorption of fibrinogen followed by its conformational deactivation. Further work is required for mechanical and haemodynamic testing in vitro and in vivo. We intend to complete the deployment and positioning studies to allow an animal study to take place, leading to commercialisation. To achieve these aims we will use a novel packaging technique to fold the stent into a small and uniform diameter avoiding geometric incompatibility. The folding is achieved by generating a set of folds onto the surface of a graft using origami-based techniques. We will make the graft from either SMA with NC coated or entirely from a radio-opaque SMNC. Coating will be achieved using electrohydrodynamic spray deposition (ESD). Spectroscopic ellipsometry (SE) and neutron reflection (NR) will be utilised to determine how durable these materials are in vitro and how they achieve biocompatibility. Successful delivery of the programme will lead to the development of a stent that has significant advantages over existing devices including geometric simplicity, a more reliable expansion mechanism, higher radial strength, the ability to shape the structure to the artery, and better biocompatibility with both blood and tissue. With engineering, materials, surface science and biological groups in close collaboration, structural design and novel manufacturing concepts can be applied to new materials development and stent fabrication, simplifying the regulatory pathway and acceptance to the marketplace. The proposal is highly likely to succeed as it has a unique integrated structure and approach. All the applicants have international reputations in their own fields, have established records in integrated adventurous projects and have recognised track records for commercialising concepts and products and as a team are well suited for carrying out the proposed research.
Organisations
People |
ORCID iD |
Jian Lu (Principal Investigator) |
Publications
Jia D
(2011)
Dynamic adsorption and structure of interfacial bilayers adsorbed from lipopeptide surfactants at the hydrophilic silicon/water interface: effect of the headgroup length.
in Langmuir : the ACS journal of surfaces and colloids
Giamblanco N
(2011)
Fibronectin conformation switch induced by coadsorption with human serum albumin.
in Langmuir : the ACS journal of surfaces and colloids
Yaseen M
(2010)
Surface structural conformations of fibrinogen polypeptides for improved biocompatibility.
in Biomaterials
Yaseen M
(2008)
Dynamic protein adsorption at the polyurethane copolymer/water interface.
in Biomedical materials (Bristol, England)
Description | Our own work focused on understanding what polymers make better biocompatible films and how to coat them onto surfaces such as bare glass (a model substrate). We showed that polyurethanes are less biocompatible than what they were thought but coating with fibrinogen, a blood clotting protein, could help improve cell attachment and growth. In addition, in collaboration with the team at UCL, we showed that incorporation of silica nanocages (glass) could also improve surface biocompatible of polyurethane surface. In collaboration with other collaborators in the project team, we showed that elastic and shape memory polymers could become a better option to make biocompatible stents with small diameters (< 5um) due to their softness and flexibility matching the veins and arteries. |
Exploitation Route | We have published joint papers, for example, Surface structural conformations of fibrinogen polypeptides for improved biocompatibility, Yaseen, Mohammed; Zhao, Xiubo; Freund, Amy; et al. BIOMATERIALS Volume: 31 Issue: 14 Pages: 3781-3792 Published: MAY 2010. |
Sectors | Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Description | School talks and school seminars during 2007-2012 for improving public understanding how surface biocompatibility of bear metal stents could be improved by coating biocompatible polymer films. During the period, we have also cited research progress in our departmental webpage. |
First Year Of Impact | 2007 |
Sector | Education,Healthcare |
Impact Types | Societal |
Description | KTP Programme Office |
Amount | £98,960 (GBP) |
Funding ID | KTP008143 |
Organisation | Knowledge Transfer Partnerships |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2011 |
End | 07/2014 |
Description | KTP Programme Office |
Amount | £98,960 (GBP) |
Funding ID | KTP008143 |
Organisation | Knowledge Transfer Partnerships |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2011 |
End | 07/2014 |
Description | UMIP |
Amount | £119,413 (GBP) |
Funding ID | R112694 |
Organisation | UMIP Premier Fund Ltd |
Sector | Private |
Country | United Kingdom |
Start |
Description | UMIP |
Amount | £119,413 (GBP) |
Funding ID | R112694 |
Organisation | University of Manchester |
Department | Intellectual Property |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2012 |
End | 06/2015 |
Description | Unilever |
Amount | £197,920 (GBP) |
Funding ID | PS-2010-0233 |
Organisation | Unilever |
Sector | Private |
Country | United Kingdom |
Start | 03/2012 |
End | 06/2015 |
Description | Unilever |
Amount | £197,920 (GBP) |
Funding ID | PS-2010-0233 |
Organisation | Unilever |
Sector | Private |
Country | United Kingdom |
Start | 01/2011 |
End | 07/2014 |