Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Armstrong J
(2023)
Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex".
in The journal of physical chemistry letters
Armstrong J
(2021)
Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex.
in The journal of physical chemistry letters
Ballesta A
(2019)
Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.
in Metallomics : integrated biometal science
Banerjee S
(2019)
Generation of maghemite nanocrystals from iron-sulfur centres.
in Dalton transactions (Cambridge, England : 2003)
Banerjee S
(2024)
Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces
in Nanoscale Advances
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Banerjee S
(2019)
Dual-action platinum(II) Schiff base complexes: Photocytotoxicity and cellular imaging
in Polyhedron
Barry N
(2014)
100 years of metal coordination chemistry: from Alfred Werner to anticancer metallodrugs
in Pure and Applied Chemistry
Barry NP
(2014)
Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
in Faraday discussions
Barry NP
(2013)
Exploration of the medical periodic table: towards new targets.
in Chemical communications (Cambridge, England)
Barry NP
(2014)
Fabrication of crystals from single metal atoms.
in Nature communications
Barry NP
(2014)
A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes.
in Dalton transactions (Cambridge, England : 2003)
Bichoutskaia E
(2012)
High-precision imaging of an encapsulated Lindqvist ion and correlation of its structure and symmetry with quantum chemical calculations
in Nanoscale
Bisceglie F
(2022)
Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (?6-arene)ruthenium(II) Complexes.
in International journal of molecular sciences
Bolitho EM
(2020)
X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Brabec V
(2016)
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.
in Journal of inorganic biochemistry
Carter R
(2016)
Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes
in Scientific Reports
Carter R
(2014)
Band gap expansion, shear inversion phase change behaviour and low-voltage induced crystal oscillation in low-dimensional tin selenide crystals.
in Dalton transactions (Cambridge, England : 2003)
Chellan P
(2021)
Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.
in Journal of inorganic biochemistry
Chellan P
(2018)
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chellan P
(2020)
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chen F
(2018)
Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.
in Organometallics
Chen F
(2018)
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.
in Journal of medicinal chemistry
Chen F
(2022)
Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes.
in Dalton transactions (Cambridge, England : 2003)
Chen JS
(2010)
Photochemistry in photonic crystal fiber nanoreactors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chen P
(2019)
Discovery of novel, potent, isosteviol-based antithrombotic agents.
in European journal of medicinal chemistry
Coverdale J
(2018)
In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
in Journal of Medicinal Chemistry
Coverdale JP
(2015)
Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Donnelly JM
(2021)
Cu(III)-bis-thiolato complex forms an unusual mono-thiolato Cu(III)-peroxido adduct.
in Chemical communications (Cambridge, England)
Dyson M
(2013)
A new approach to high resolution, high contrast electron microscopy of macromolecular block copolymer assemblies
in Soft Matter
Farley SJ
(2022)
Photoactive Platinum(II) Azopyridine Complexes.
in Photochemistry and photobiology
Faulques E
(2016)
Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
in Journal of Visualized Experiments
Fu Y
(2016)
Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity.
in Angewandte Chemie (International ed. in English)
Fu Y
(2016)
Os 2 -Os 4 Switch Controls DNA Knotting and Anticancer Activity
in Angewandte Chemie
Fu Y
(2016)
The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts.
in Dalton transactions (Cambridge, England : 2003)
Gandioso A
(2015)
An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies.
in Chemical communications (Cambridge, England)
Gatti A
(2018)
Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity.
in Organometallics
Gondim A
(2019)
Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity
in MedChemComm
Gondim ACS
(2017)
The potent anti-cancer activity of Dioclea lasiocarpa lectin.
in Journal of inorganic biochemistry
Gothe Y
(2018)
Synthesis and Mode of Action Studies on Iridium(I)-NHC Anticancer Drug Candidates
in European Journal of Inorganic Chemistry
Huang H
(2019)
Targeted photoredox catalysis in cancer cells.
in Nature chemistry
Imberti C
(2020)
New Designs for Phototherapeutic Transition Metal Complexes.
in Angewandte Chemie (International ed. in English)
Kashtiban RJ
(2014)
Atomically resolved imaging of highly ordered alternating fluorinated graphene.
in Nature communications
Kilgour DP
(2012)
Use of an artificial immune system derived method for the charge state assignment of small-molecule mass spectra.
in Analytical chemistry
Kilgour DP
(2012)
Appropriate degree of trust: deriving confidence metrics for automatic peak assignment in high-resolution mass spectrometry.
in Analytical chemistry
Kilgour DP
(2013)
Autophaser: an algorithm for automated generation of absorption mode spectra for FT-ICR MS.
in Analytical chemistry
Kumar SA
(2021)
Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice.
in Metallomics : integrated biometal science
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Lam YPY
(2020)
Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Li H
(2011)
Mass spectrometry evidence for cisplatin as a protein cross-linking reagent.
in Analytical chemistry