The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Pérez-Victoria I
(2009)
Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein.
in Chemical communications (Cambridge, England)
Ribeiro-Viana R
(2012)
Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection.
in Nature communications
Russell D
(2009)
Site-selective chemical protein glycosylation protects from autolysis and proteolytic degradation.
in Carbohydrate research
Rutte RN
(2014)
Modification of fulleropyrazolines modulates their cleavage by light.
in Chemical communications (Cambridge, England)
Sagar R
(2012)
Conformational effects in sugar ions: spectroscopic investigations in the gas phase and in solution
in Chemical Science
Scanlan EM
(2010)
Synthesis and solution-phase conformation of the RG-I fragment of the plant polysaccharide pectin reveals a modification-modulated assembly mechanism.
in Journal of the American Chemical Society
Schiffner T.
(2013)
Focusing Antibody Responses to Specific Protein Surfaces Through Site-Selective Glycan Addition
in AIDS RESEARCH AND HUMAN RETROVIRUSES
Schiffner Torben
(2014)
Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens
in AIDS RESEARCH AND HUMAN RETROVIRUSES
Schuster HJ
(2015)
Chain-growth polyglycosylation: synthesis of linker-equipped mannosyl oligomers.
in Carbohydrate research
Seebach D
(2009)
Polymer backbone conformation--a challenging task for database information retrieval.
in Angewandte Chemie (International ed. in English)
Serres S
(2009)
Systemic inflammatory response reactivates immune-mediated lesions in rat brain.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Simons J
(2009)
Conformational change and selectivity in explicitly hydrated carbohydrates
in Tetrahedron: Asymmetry
Simons John P.
(2011)
Gas phase spectroscopy of hydrated carbohydrates: The anomeric effect laid bare
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Spicer C
(2011)
Palladium-Mediated Cell-Surface Labeling
in Journal of the American Chemical Society
Spicer CD
(2011)
Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides.
in Chemical communications (Cambridge, England)
Spicer CD
(2013)
Rewriting the bacterial glycocalyx via Suzuki-Miyaura cross-coupling.
in Chemical communications (Cambridge, England)
Spicer Christopher D.
(2013)
Suzuki biology: Palladium mediated protein modification
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Vallée MR
(2016)
Ready display of antigenic peptides in a protein 'mimogen'.
in Chemical communications (Cambridge, England)
Van Kasteren SI
(2009)
Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.
in Proceedings of the National Academy of Sciences of the United States of America
Wang LX
(2013)
Realizing the Promise of Chemical Glycobiology.
in Chemical science
Wyszynski F
(2010)
Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster
in Chemical Science
Wyszynski FJ
(2010)
Inverted regioselectivity of C-H amination: Unexpected oxidation at beta- rather than gamma-C-H.
in Organic & biomolecular chemistry
Wyszynski FJ
(2012)
Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates.
in Nature chemistry
Xue X
(2011)
Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference.
in Angewandte Chemie (International ed. in English)
Xue Xuan
(2011)
Synthetic polymers for interference with bacterial communication
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Yamamoto K
(2012)
Creation of an a-mannosynthase from a broad glycosidase scaffold.
in Angewandte Chemie (International ed. in English)
| Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
| Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
| Sectors | Education,Pharmaceuticals and Medical Biotechnology |
| URL | http://users.ox.ac.uk/~dplb0149/index.html |
| Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
| First Year Of Impact | 2009 |
| Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
| Impact Types | Cultural,Societal,Economic,Policy & public services |
| Company Name | Glycoform Ltd |
| Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
| Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
| Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |