Molecular assembly using gold catalysis
Lead Research Organisation:
University of St Andrews
Department Name: Chemistry
Abstract
The development of catalytic methods leading to little or no waste is an area of crucial importance in terms of energy and materials economy. The present proposal presents strategies to assemble complex molecular architectures or value-added compounds using simply synthesized organogold complexes. The proposal adopts a two-prong approach. On the one side the design and synthesis of organogold catalysts are proposed and on the other some of the catalysts already synthesized by our group and the novel ones are proposed to enable important chemical transformations. These range from hydration reactions to tandem reactions leading to multiple bond formations in a single step. The aim of the proposal is to develop useful synthetic tools, readily usable by synthetic chemists permitting facile protocols enabling the synthesis of complex molecular assemblies.
Organisations
People |
ORCID iD |
Steven Nolan (Principal Investigator) |
Publications
Fortman G
(2010)
A Versatile Cuprous Synthon: [Cu(IPr)(OH)] (IPr = 1,3 bis(diisopropylphenyl)imidazol-2-ylidene)
in Organometallics
Boogaerts II
(2010)
Carboxylation of N-H/C-H bonds using N-heterocyclic carbene copper(I) complexes.
in Angewandte Chemie (International ed. in English)
Brulé E
(2011)
Polymerization of Racemic ß-Butyrolactone Using Gold Catalysts: A Simple Access to Biodegradable Polymers
in Organometallics
Nun P
(2011)
A combined mechanistic and computational study of the gold(I)-catalyzed formation of substituted indenes.
in Organic & biomolecular chemistry
Merlini V
(2011)
Gold-mediated synthesis of a-ionone
in Tetrahedron Letters
Nolan SP
(2011)
The development and catalytic uses of N-heterocyclic carbene gold complexes.
in Accounts of chemical research
Patrick SR
(2011)
The role of silver additives in gold-mediated C-H functionalisation.
in Beilstein journal of organic chemistry
Konkolewicz D
(2011)
Luminescent Hyperbranched Polymers: Combining Thiol-Yne Chemistry with Gold-Mediated C-H Bond Activation
in Organometallics
Fortman GC
(2011)
Catalytic deuteration of silanes mediated by N-heterocyclic carbene-Ir(III) complexes.
in Chemical communications (Cambridge, England)
Nun P
(2011)
Efficient silver-free gold(I)-catalyzed hydration of alkynes at low catalyst loading
in Journal of Organometallic Chemistry