Molecular assembly using gold catalysis
Lead Research Organisation:
University of St Andrews
Department Name: Chemistry
Abstract
The development of catalytic methods leading to little or no waste is an area of crucial importance in terms of energy and materials economy. The present proposal presents strategies to assemble complex molecular architectures or value-added compounds using simply synthesized organogold complexes. The proposal adopts a two-prong approach. On the one side the design and synthesis of organogold catalysts are proposed and on the other some of the catalysts already synthesized by our group and the novel ones are proposed to enable important chemical transformations. These range from hydration reactions to tandem reactions leading to multiple bond formations in a single step. The aim of the proposal is to develop useful synthetic tools, readily usable by synthetic chemists permitting facile protocols enabling the synthesis of complex molecular assemblies.
Organisations
People |
ORCID iD |
Steven Nolan (Principal Investigator) |
Publications
Boogaerts I
(2011)
Direct C-H carboxylation with complexes of the coinage metals
in Chem. Commun.
Boogaerts II
(2010)
Carboxylation of C-H bonds using N-heterocyclic carbene gold(I) complexes.
in Journal of the American Chemical Society
Boogaerts II
(2010)
Carboxylation of N-H/C-H bonds using N-heterocyclic carbene copper(I) complexes.
in Angewandte Chemie (International ed. in English)
Brulé E
(2011)
Polymerization of Racemic ß-Butyrolactone Using Gold Catalysts: A Simple Access to Biodegradable Polymers
in Organometallics
Cera G
(2012)
One-pot gold-catalyzed synthesis of azepino[1,2-a]indoles.
in Angewandte Chemie (International ed. in English)
Diebolt O
(2010)
Mixed Phosphite/ N -Heterocyclic Carbene Complexes: Synthesis, Characterization and Catalytic Studies
in Organometallics
Dupuy S
(2011)
Decarboxylation of aromatic carboxylic acids by gold(I)-N-heterocyclic carbene (NHC) complexes.
in Chemical communications (Cambridge, England)
Dupuy S
(2012)
The fluoride-free transmetalation of organosilanes to gold.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Fortman G
(2010)
Solution Calorimetric Study of Ligand Exchange Reactions in the [Au(L)Cl] System (L = Phosphine and Phosphite)
in Organometallics
Fortman G
(2010)
A Versatile Cuprous Synthon: [Cu(IPr)(OH)] (IPr = 1,3 bis(diisopropylphenyl)imidazol-2-ylidene)
in Organometallics
Fortman GC
(2010)
A versatile gold synthon for acetylene C-H bond activation.
in Dalton transactions (Cambridge, England : 2003)
Fortman GC
(2011)
Catalytic deuteration of silanes mediated by N-heterocyclic carbene-Ir(III) complexes.
in Chemical communications (Cambridge, England)
Gaillard S
(2009)
Synthetic and Structural Studies of [AuCl 3 (NHC)] Complexes
in Organometallics
Gaillard S
(2010)
Development of versatile and silver-free protocols for gold(I) catalysis.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Gaillard S
(2010)
A N-heterocyclic carbene gold hydroxide complex: a golden synthon.
in Chemical communications (Cambridge, England)
Gaillard S
(2012)
Phosphate binding to the [Au(IPr)] moiety: inner vs. outer sphere coordination behaviour.
in Dalton transactions (Cambridge, England : 2003)
Gómez-Suárez A
(2012)
Dinuclear gold catalysis: are two gold centers better than one?
in Angewandte Chemie (International ed. in English)
Gómez-Suárez A
(2011)
Influence of a Very Bulky N- Heterocyclic Carbene in Gold-Mediated Catalysis
in Organometallics
Hashmi A
(2011)
Selectivity Switch in the Synthesis of Vinylgold(I) Intermediates
in Organometallics
Konkolewicz D
(2011)
Luminescent Hyperbranched Polymers: Combining Thiol-Yne Chemistry with Gold-Mediated C-H Bond Activation
in Organometallics
Merlini V
(2011)
Gold-mediated synthesis of a-ionone
in Tetrahedron Letters
Nolan SP
(2011)
The development and catalytic uses of N-heterocyclic carbene gold complexes.
in Accounts of chemical research
Nun P
(2011)
A combined mechanistic and computational study of the gold(I)-catalyzed formation of substituted indenes.
in Organic & biomolecular chemistry
Nun P
(2010)
Ligand influence in the selective gold-mediated synthesis of allenes.
in Chemical communications (Cambridge, England)
Nun P
(2011)
Efficient silver-free gold(I)-catalyzed hydration of alkynes at low catalyst loading
in Journal of Organometallic Chemistry
Patrick SR
(2011)
The role of silver additives in gold-mediated C-H functionalisation.
in Beilstein journal of organic chemistry
Ramón R
(2010)
Gold-Catalyzed Meyer-Schuster Rearrangement: Application to the Synthesis of Prostaglandins
in Organometallics
Ramón RS
(2010)
Au/Ag-cocatalyzed aldoximes to amides rearrangement under solvent- and acid-free conditions.
in The Journal of organic chemistry