Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
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People |
ORCID iD |
Philip Alan Gale (Principal Investigator) |
Publications
Wu X
(2018)
Supramolecular Transmembrane Anion Transport: New Assays and Insights.
in Accounts of chemical research
Wu X
(2015)
Dynamic covalent transport of amino acids across lipid bilayers.
in Journal of the American Chemical Society
Valkenier H
(2014)
Lipophilic balance - a new design principle for transmembrane anion carriers
in Chemical Science
Spooner MJ
(2019)
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport.
in Chemical science
Park SH
(2019)
Determinants of Ion-Transporter Cancer Cell Death.
in Chem
Moore S
(2013)
Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
in Chem. Sci.
Merckx T
(2015)
Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines.
in Organic & biomolecular chemistry
Marques I
(2018)
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations.
in Physical chemistry chemical physics : PCCP
Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Australian Research Council Discovery Grant 2018 |
Amount | $524,708 (AUD) |
Funding ID | DP180100612 |
Organisation | Australian Research Council |
Sector | Public |
Country | Australia |
Start | 01/2018 |
End | 12/2020 |