Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
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People |
ORCID iD |
Philip Alan Gale (Principal Investigator) |
Publications
Busschaert N
(2017)
A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations.
in Nature chemistry
Haynes CJ
(2014)
Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding.
in Organic & biomolecular chemistry
Merckx T
(2015)
Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines.
in Organic & biomolecular chemistry
Gale P
(2016)
Anion Receptor Chemistry
in Chem
Gale P
(2014)
Anion receptor chemistry: highlights from 2011 and 2012
in Chem. Soc. Rev.
Cranwell PB
(2013)
Anion recognition and transport properties of sulfamide-, phosphoric triamide- and thiophosphoric triamide-based receptors.
in Chemical communications (Cambridge, England)
Busschaert N
(2015)
Applications of Supramolecular Anion Recognition.
in Chemical reviews
Berry SN
(2015)
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism.
in Organic & biomolecular chemistry
Moore S
(2013)
Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
in Chem. Sci.
Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Australian Research Council Discovery Grant 2018 |
Amount | $524,708 (AUD) |
Funding ID | DP180100612 |
Organisation | Australian Research Council |
Sector | Public |
Country | Australia |
Start | 01/2018 |
End | 12/2020 |