Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
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People |
ORCID iD |
Philip Alan Gale (Principal Investigator) |
Publications
Wu X
(2018)
Supramolecular Transmembrane Anion Transport: New Assays and Insights.
in Accounts of chemical research
Edwards S
(2015)
High-Affinity Anion Binding by Steroidal Squaramide Receptors
in Angewandte Chemie
Edwards SJ
(2015)
High-affinity anion binding by steroidal squaramide receptors.
in Angewandte Chemie (International ed. in English)
Gale P
(2016)
Anion Receptor Chemistry
in Chem
Park SH
(2019)
Determinants of Ion-Transporter Cancer Cell Death.
in Chem
Moore S
(2013)
Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
in Chem. Sci.
Gale P
(2014)
Anion receptor chemistry: highlights from 2011 and 2012
in Chem. Soc. Rev.
Cranwell PB
(2013)
Anion recognition and transport properties of sulfamide-, phosphoric triamide- and thiophosphoric triamide-based receptors.
in Chemical communications (Cambridge, England)
Haynes CJ
(2013)
Small neutral molecular carriers for selective carboxylate transport.
in Chemical communications (Cambridge, England)
Elmes RB
(2015)
pH switchable anion transport by an oxothiosquaramide.
in Chemical communications (Cambridge, England)
Karagiannidis LE
(2014)
Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas.
in Chemical communications (Cambridge, England)
Busschaert N
(2015)
Applications of Supramolecular Anion Recognition.
in Chemical reviews
Busschaert N
(2014)
Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport
in Chemical Science
Berry SN
(2016)
Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells.
in Chemical science
Spooner MJ
(2019)
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport.
in Chemical science
Knight NJ
(2016)
QSAR analysis of substituent effects on tambjamine anion transporters.
in Chemical science
Busschaert N
(2013)
Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
in Chemical Science
Busschaert N
(2014)
Thiosquaramides: pH switchable anion transporters.
in Chemical science
Valkenier H
(2014)
Lipophilic balance - a new design principle for transmembrane anion carriers
in Chemical Science
Kadam SA
(2015)
Towards the discrimination of carboxylates by hydrogen-bond donor anion receptors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Wu X
(2015)
Dynamic covalent transport of amino acids across lipid bilayers.
in Journal of the American Chemical Society
Howe EN
(2016)
pH-Regulated Nonelectrogenic Anion Transport by Phenylthiosemicarbazones.
in Journal of the American Chemical Society
Jowett LA
(2019)
Investigating the Influence of Steric Hindrance on Selective Anion Transport.
in Molecules (Basel, Switzerland)
Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Australian Research Council Discovery Grant 2018 |
Amount | $524,708 (AUD) |
Funding ID | DP180100612 |
Organisation | Australian Research Council |
Sector | Public |
Country | Australia |
Start | 01/2018 |
End | 12/2020 |