Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Philip Alan Gale (Principal Investigator) |
Publications
Elmes RB
(2015)
pH switchable anion transport by an oxothiosquaramide.
in Chemical communications (Cambridge, England)
Gale P
(2014)
Anion receptor chemistry: highlights from 2011 and 2012
in Chem. Soc. Rev.
Gale P
(2016)
Anion Receptor Chemistry
in Chem
Haynes CJ
(2013)
Small neutral molecular carriers for selective carboxylate transport.
in Chemical communications (Cambridge, England)
Haynes CJ
(2014)
Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding.
in Organic & biomolecular chemistry
Howe EN
(2016)
pH-Regulated Nonelectrogenic Anion Transport by Phenylthiosemicarbazones.
in Journal of the American Chemical Society
Jowett LA
(2019)
Investigating the Influence of Steric Hindrance on Selective Anion Transport.
in Molecules (Basel, Switzerland)
Kadam SA
(2015)
Towards the discrimination of carboxylates by hydrogen-bond donor anion receptors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Karagiannidis LE
(2014)
Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas.
in Chemical communications (Cambridge, England)
Knight NJ
(2016)
QSAR analysis of substituent effects on tambjamine anion transporters.
in Chemical science
| Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
| Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
| Sectors | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Australian Research Council Discovery Grant 2018 |
| Amount | $524,708 (AUD) |
| Funding ID | DP180100612 |
| Organisation | Australian Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2018 |
| End | 12/2020 |