Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants
Lead Research Organisation:
University of Bristol
Department Name: Oral and Dental Science
Abstract
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Organisations
- University of Bristol (Lead Research Organisation)
- University of Science and Technology Beijing (Collaboration)
- National Physical Laboratory (Collaboration)
- Renishaw (United Kingdom) (Collaboration)
- City University of Hong Kong (Collaboration)
- Polytechnic University of Catalonia (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Tsimbouri PM
(2016)
Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates.
in Scientific reports
Xu W
(2020)
Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications.
in Bioactive materials
Yu A
(2023)
Additive manufacturing of multi-morphology graded titanium scaffolds for bone implant applications
in Journal of Materials Science & Technology
Zhang L
(2017)
Gelatin freeze casting of biomimetic titanium alloy with anisotropic and gradient pore structure.
in Biomedical materials (Bristol, England)
Description | We have identified that certain nanotopographies possess antimicrobial properties while directing stem cells into osteogenesis, a important step for the design of 'cell-instructive' smart implants |
Exploitation Route | Implant manufacturers and tissue engineering researchers may find it useful to fabricate functional materials or scaffolds with antimicrobial performance |
Sectors | Healthcare,Manufacturing, including Industrial Biotechology |
Description | (Bio-TUNE) - Fine tune of cellular behavior: multifunctional materials for medical implants |
Amount | € 814,200 (EUR) |
Funding ID | 872869 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2020 |
End | 12/2023 |
Description | Biophysical stimulation-enhanced antimicrobial surfaces to combat implant-associated infections |
Amount | £53,991 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2017 |
End | 05/2018 |
Description | Bristolbridge |
Amount | £25,395 (GBP) |
Funding ID | CHEM RB1768 (EP/M027546/1) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2016 |
End | 04/2016 |
Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
Amount | £699,713 (GBP) |
Funding ID | MR/S010343/1 |
Organisation | University of Bristol |
Sector | Academic/University |
Country | United Kingdom |
Start | 06/2019 |
End | 05/2022 |
Description | MRC Innovation Grant |
Amount | £200,000 (GBP) |
Funding ID | MR/N010345/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2016 |
End | 03/2018 |
Description | Multiscale topographies to modulate cells and bacteria |
Amount | £313,423 (GBP) |
Funding ID | EP/K035142/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2013 |
End | 12/2016 |
Description | emPOWER: in-body artificial muscles for physical augmentation, function restoration, patient empowerment and future healthcare |
Amount | £6,142,804 (GBP) |
Funding ID | EP/T020792/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 08/2026 |
Title | Analysis of osteoclastogenesis / osteoblastogenesis on nanotopographical titania surfaces. |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Title | Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Description | 3D printed Ti implants |
Organisation | Renishaw PLC |
Country | United Kingdom |
Sector | Private |
PI Contribution | Provide 3D printed Ti implants for surface nanopatterning |
Collaborator Contribution | Provide samples of 3DP Ti blocks for surface patterning and microbiological testing |
Impact | Advanced manufacturing and medical devices |
Start Year | 2020 |
Description | Antimicrobial diamond nanocones |
Organisation | City University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | Search for antimicrobial surfaces to tackle AMR problem |
Collaborator Contribution | Provide diamond nanocone surfaces using a CVD and etching technique |
Impact | A joint publication in Biointerphase Journal |
Start Year | 2015 |
Description | Cell-instructive materials |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Nanopatterning of Ti surfaces |
Collaborator Contribution | Peptides functionalisation |
Impact | Two joint publications. Two successful CASE studentships (EPSRC and BBSRC). Multidisciplinary collaboration in biomaterials, peptides chemistry, microbiology and stem cell biology |
Start Year | 2015 |
Description | In vitro and in vivo study of antimicrobial surfaces |
Organisation | University of Cambridge |
Department | Department of Veterinary Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaboration is underway through a PhD studentship of Cambridge University with Prof Matthew Allen to test the developed antimicrobial nano-surfaces in a rabbit model. |
Collaborator Contribution | Prof Allen and his student will perform both in vitro and in vivo testing of our nanostructured surfaces in both 2D substrates and 3D printed implants. |
Impact | This is a multi-disciplinary collaboration between materials and biological sciences. Joint publications and future grand application are expected. |
Start Year | 2018 |
Description | Novel 3D Printed Ti implants |
Organisation | University of Science and Technology Beijing |
Country | China |
Sector | Academic/University |
PI Contribution | The USTB provides newly developed 3D printed Ti alloy implants for surface nanostructuring at University of Bristol. |
Collaborator Contribution | We carry out nanopatterning of Ti implants and stem cells/microbiological studies to produce cell-instructive surfaces. |
Impact | So far, 3 joint publications were obtained. |
Start Year | 2020 |
Description | Stem cell response to bactericidal nanospikes |
Organisation | University of Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provide bactericidal surfaces |
Collaborator Contribution | In vitro and in vivo tests |
Impact | multi-disciplinary, biomaterials and stem cell biology, at least one paper expected, possible follow on grant application |
Start Year | 2015 |
Description | cell-instructive surfaces |
Organisation | Polytechnic University of Catalonia |
Country | Spain |
Sector | Academic/University |
PI Contribution | Nanostructured surfaces: generation and characterisation |
Collaborator Contribution | Functionalisation of nano-surfaces with cell-binding ligands to improve cell attachment while preventing bacterial growth |
Impact | A joint publication in Scientific Reports. One more in preparation. |
Start Year | 2017 |
Title | Smart implants for orthopaedics and dentistry |
Description | Under two EPSRC funding, we have been developing cell-instructive titanium implants for orthopaedic and dental applications. So far, materials development and in vitro testing have been carried out. The next step is in vivo testing and clinical trials. |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2016 |
Development Status | Actively seeking support |
Impact | Still under development, not yet |
Description | Big Bang Bristol |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Big Bang Bristol was a free two-day science, technology, engineering and maths (STEM) extravaganza at the Trinity Arts Centre, Bristol, in July 2017. Visitors will be able to learn about the world-class research taking place in the region, find out about life as a postgraduate and how to become a professor. We have participated and showcased our research on bio-inspired bactericidal nanospike surfaces which attracted a lot of interests in our research. |
Year(s) Of Engagement Activity | 2017 |
Description | Biofilm Create! Competition 2022 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A competition organised by the National Biofilm Innovation Centre funded by the UKRI (BBSRC). |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.biofilms.ac.uk/biofilm-create-competition-2022-winners/ |
Description | FUTURES festival on 30th Sep 2022 held in SS Great Britain, Bristol |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Outreach event to showcase researches in the University |
Year(s) Of Engagement Activity | 2023 |
Description | From deep-sea sponges to dragonfly wings: Superbug research from unexpected places |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Media coverage of our work on 'fighting bacteria using bio-inspired materials'. |
Year(s) Of Engagement Activity | 2018 |
URL | https://mrc.ukri.org/news/blog/from-deep-sea-sponges-to-dragonfly-wings-superbug-research-from-unexp... |
Description | Invited Talk , Advanced Powder Materials Online Forum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | An online event organised by the Central South University of China |
Year(s) Of Engagement Activity | 2022 |
Description | Invited lecture, London Interdisciplinary Biosciences Consortium, UK |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | PhD students based in BBSRC DTP in London Interdisciplinary Biosciences Consortium attended this lecture. |
Year(s) Of Engagement Activity | 2023 |
Description | Invited talk at 'antimicrobial surfaces' workshop (Sheffield University) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | More than 100 people attended this workshop on antimicrobial surfaces organised by Sheffield University. Our bio-inspired antimicrobial surfaces sparked a lot of interests in seeking alternative therapies for antibiotic-resistance problem. |
Year(s) Of Engagement Activity | 2016 |
Description | Invited talk at Biointerface conference (Newcastle University) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Up to 100 people attend this conference organised by the Newcastle University. A lot of interests were received on nanotopographical modulation of cells and bacteria for medical implant applications |
Year(s) Of Engagement Activity | 2016 |
Description | Invited talk at IUMRS2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | International conference invited talk |
Year(s) Of Engagement Activity | 2016 |
Description | Invited talk at National Honey Show |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Invited to give a talk on our research in insect wing inspired antimicrobial surfaces to beekeepers and general public. |
Year(s) Of Engagement Activity | 2021 |
Description | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
Year(s) Of Engagement Activity | 2016 |
Description | Invited talk in a workshop organised by the Institute for Molecular Science and Engineering (IMSE) at Imperial College London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Audience from a number of different department at Imperial, including Materials, Medicine, Mathematics, Life Sciences, Chemical Engineering, Chemistry, and the Imperial NHS Trust attended. |
Year(s) Of Engagement Activity | 2017 |
Description | Invited talk in an international conference of Advanced Materials organised by Newcastle University |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | International audience mostly from Europe attended this conference |
Year(s) Of Engagement Activity | 2016 |
Description | Invited visits to Indian Institute of Technology and National Institute of Technology India |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Boosted possible collaborations with the two top institutions in India. Discussed possible funding from Newton Fund. |
Year(s) Of Engagement Activity | 2015 |
Description | Invited visits to Shang Institute of Ceramics and Zhejiang University, China |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Boosted collaboration with two top research institutions in China. |
Year(s) Of Engagement Activity | 2015 |
Description | Keynote lecture in International Forum and Silk Road Conference on Advanced Functional Films and Coatings, Xi'an, China |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The intended purpose of this international forum was to exchange the latest research information on surface engineering. i was invited to give a keynote lecture on our work on antimicrobial surfaces. |
Year(s) Of Engagement Activity | 2020 |
Description | Keynote lecture, International Conference on Emerging Trends of Healthcare Technology in Post-COVID-19 Era, Indian Institute of Technology, Kharagpur, India |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | An online international conference organised by IIT Kharagpur, India. The intended purpose was to report latest development in medical technology in post-COVID-19 era. I was invited to give a keynote lecture on our work on smart implants. |
Year(s) Of Engagement Activity | 2020 |
Description | Kill superbugs with nanospears |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Research without boarders |
Year(s) Of Engagement Activity | 2018 |
Description | Nanobio workshop, Leuven, Belgium |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Invited talk at Nanobio workshop, organised by Vision Dynamics Science & Entrepreneurship. Audiences are mainly from European universities and SMEs. Disseminated our work to wider communities. A collaboration was initiated in this workshop with a UK company (Nanokicking) based in Glasgow. |
Year(s) Of Engagement Activity | 2017 |
Description | National Biofilms Innovation Centre (NBIC) All Research Partner meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Researchers and industrial partners to exchange information of their research under the NBIC memberships |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.biofilms.ac.uk/ |
Description | Plenary lecture 'Cell-instructive surfaces via nanotopography' in Euro Biomat, Germany 2015 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | Novel approaches to generate smart materials and surfaces |
Year(s) Of Engagement Activity | 2015 |
Description | Plenary talk at Hunan Bone Summit |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary talk to doctors and university |
Year(s) Of Engagement Activity | 2016 |
Description | Poster presentation, Infection and Immunity Research Network Early Career Researchers' event, University of Bristol, 1st Feb 2023 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Annual event organised by the University, esp. for ECRs |
Year(s) Of Engagement Activity | 2023 |
Description | Poster presentation, The 8th Thesinge Biofilm Conference, May 23-24, 2022, The Netherlands |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | An international conference held biennially with about 200-300 participants from academia and industries. |
Year(s) Of Engagement Activity | 2022 |
URL | https://biofilm-thesinge.com/index.php |
Description | RSC Poster 2023 - Twitter Conference |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | An online conference organised by the RSC. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.rsc.org/our-events/rsc-poster/ |