Core capability for Chemistry Research
Lead Research Organisation:
Imperial College London
Department Name: Chemistry
Abstract
The National Importance of a vibrant and successful university Chemistry research sector cannot be underestimated. The RSC's report on the Economic Benefits of Chemistry showed that the UK's upstream chemicals industry and downstream chemistry-using sectors contributed a combined total of £258 billion in added-value in 2007, equivalent to 21% of UK GDP, and supported over 6 million UK jobs. This output is underpinned by some of the world's most successful University Chemistry research, reflecting the fruits of many years of investment. On-going fundamental research is essential, not only to maintain a continuing flow of scientific and technological breakthroughs, but also to ensure that the UK maintains a highly skilled and innovative workforce; it is through these trained people that the UK will adopt and advance new ideas, successfully exploit new technologies, and develop new and better products and services. The ability to develop and exploit chemically-derived technology will fuel economic activity, and is a necessary condition for attracting inward investment to the UK. The RSC report also showed that the quality of UK chemists and the reputation for excellence of the UK's university chemical science base significantly influences companies in decisions to locate within the UK, or to retain a UK-based research presence.
Imperial College is an internationally leading centre for research, education and translation. It is the only UK higher education institution to focus exclusively on science, engineering, medicine and business. The College is renowned both for world-class fundamental research and for the translation of this research to benefit society and the economy; this combination was indeed defined as a core part of the College's mission at its foundation in 1907. Its research strengths reflect its focus on fundamental underpinning science and cover the breadth of engineering and the physical sciences. The College currently holds 270 research grants totalling over £285M that have been through the EPSRC's peer review process; these include 11 Programme Grants and 12 Platform Grants.
The equipment requested is to underpin the above activity.
Imperial College is an internationally leading centre for research, education and translation. It is the only UK higher education institution to focus exclusively on science, engineering, medicine and business. The College is renowned both for world-class fundamental research and for the translation of this research to benefit society and the economy; this combination was indeed defined as a core part of the College's mission at its foundation in 1907. Its research strengths reflect its focus on fundamental underpinning science and cover the breadth of engineering and the physical sciences. The College currently holds 270 research grants totalling over £285M that have been through the EPSRC's peer review process; these include 11 Programme Grants and 12 Platform Grants.
The equipment requested is to underpin the above activity.
Planned Impact
Please see Pathways to Impact
Organisations
Publications
Craig D
(2013)
Aziridine-based concise synthesis of (±)-alstonerine.
in Chemical communications (Cambridge, England)
D'Arcy M
(2013)
Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment To Study a Fundamental Environmental Engineering Problem
in Journal of Chemical Education
Braddock DC
(2013)
Epoxidation of bromoallenes connects red algae metabolites by an intersecting bromoallene oxide--Favorskii manifold.
in Chemical communications (Cambridge, England)
Ashley AE
(2013)
FLP-mediated activations and reductions of CO2 and CO.
in Topics in current chemistry
Braddock DC
(2013)
An enantiospecific polyene cyclization initiated by an enantiomerically pure bromonium ion.
in Chirality
Moffat CD
(2014)
Molecular recognition and scavenging of arsenate from aqueous solution using dimetallic receptors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Campbell J
(2014)
Fabrication of hybrid polymer/metal organic framework membranes: mixed matrix membranes versus in situ growth
in J. Mater. Chem. A
Moragues ME
(2014)
A chromo-fluorogenic synthetic "canary" for CO detection based on a pyrenylvinyl ruthenium(II) complex.
in Journal of the American Chemical Society
Dickson CJ
(2014)
Lipid14: The Amber Lipid Force Field.
in Journal of chemical theory and computation
Schrems A
(2014)
The grab-and-drop protocol: a novel strategy for membrane protein isolation and reconstitution from single cells.
in The Analyst
Japrung D
(2014)
SSB binding to single-stranded DNA probed using solid-state nanopore sensors.
in The journal of physical chemistry. B
Hurtubise VL
(2014)
Multimetallic complexes and functionalized nanoparticles based on unsymmetrical dithiocarbamate ligands with allyl and propargyl functionality.
in Inorganic chemistry
Yau C
(2014)
Investigation of Radical and Cationic Cross-Linking in High-Efficiency, Low Band Gap Solar Cell Polymers
in Advanced Energy Materials
Boultwood T
(2014)
Synthesis and purification of iodoaziridines involving quantitative selection of the optimal stationary phase for chromatography.
in Journal of visualized experiments : JoVE
Hutton JA
(2014)
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
in Journal of medicinal chemistry
Bomparola R
(2014)
Lithium heterocuprates: the influence of the amido group on organoamidocuprate structures.
in Dalton transactions (Cambridge, England : 2003)
Ivanov AP
(2014)
High precision fabrication and positioning of nanoelectrodes in a nanopore.
in ACS nano
Casey D
(2014)
Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature
in Journal of The Royal Society Interface
Ciepla P
(2014)
New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.
in Chemical science
O'Donnelly K
(2014)
Isolation and kinetic characterisation of hydrophobically distinct populations of form I Rubisco.
in Plant methods
Burés J
(2014)
Rationalization of an unusual solvent-induced inversion of enantiomeric excess in organocatalytic selenylation of aldehydes.
in Angewandte Chemie (International ed. in English)
Lin Y
(2014)
The Pentynoate Ligand as a Building Block for Multimetallic Systems
in European Journal of Inorganic Chemistry
Carmona D
(2014)
Chiral transition-metal complexes as Brønsted-acid catalysts for the asymmetric Friedel-Crafts hydroxyalkylation of indoles.
in Dalton transactions (Cambridge, England : 2003)
Kakati B
(2014)
Gas phase recovery of hydrogen sulfide contaminated polymer electrolyte membrane fuel cells
in Journal of Power Sources
Tang H
(2014)
Glass polyalkenoate cements based on simple CaO-Al 2 O 3 -SiO 2 glasses
in Materials Science and Technology
Gibb TR
(2014)
Single molecule ionic current sensing in segmented flow microfluidics.
in Analytical chemistry
Arrowsmith M
(2014)
Catalytic hydroacetylenation of carbodiimides with homoleptic alkaline earth hexamethyldisilazides.
in Dalton transactions (Cambridge, England : 2003)
Pastor E
(2014)
Interfacial charge separation in Cu2O/RuO(x) as a visible light driven CO2 reduction catalyst.
in Physical chemistry chemical physics : PCCP
Munira Haidad Ali S
(2014)
Copper(II) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA.
in Dalton transactions (Cambridge, England : 2003)
Greenhalgh E
(2014)
Mechanical, electrical and microstructural characterisation of multifunctional structural power composites
in Journal of Composite Materials
Chumphukam O
(2014)
High efficiency acetylcholinesterase immobilization on DNA aptamer modified surfaces.
in Molecules (Basel, Switzerland)
Amor B
(2014)
Uncovering allosteric pathways in caspase-1 using Markov transient analysis and multiscale community detection.
in Molecular bioSystems
Ab Rani M
(2014)
The potential of methylsiloxanes as solvents for synthetic chemistry applications
in Green Chem.
Freedman KJ
(2014)
Nonequilibrium capture rates induce protein accumulation and enhanced adsorption to solid-state nanopores.
in ACS nano
Affron DP
(2014)
Regio- and stereospecific synthesis of C-3 functionalized proline derivatives by palladium catalyzed directed C(sp3)-H arylation.
in Organic letters
Varcoe J
(2014)
Anion-exchange membranes in electrochemical energy systems
in Energy Environ. Sci.
Brooks N
(2014)
Pressure effects on lipids and bio-membrane assemblies
in IUCrJ
Le TT
(2014)
Aptamer-based biosensors for the rapid visual detection of flu viruses.
in Chemical communications (Cambridge, England)
Timokhin I
(2014)
Microporous metal-organic frameworks built from rigid tetrahedral tetrakis(4-tetrazolylphenyl)silane connectors
in CrystEngComm
Jenkins S
(2014)
The response of the electronic structure to electronic excitation and double bond torsion in fulvene: a combined QTAIM, stress tensor and MO perspective.
in Physical chemistry chemical physics : PCCP
Nako AE
(2014)
Yttrium-catalysed dehydrocoupling of alanes with amines.
in Chemical communications (Cambridge, England)
Evans HL
(2014)
Bioorthogonal chemistry for (68) Ga radiolabelling of DOTA-containing compounds.
in Journal of labelled compounds & radiopharmaceuticals
Douse C
(2014)
Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex
in ChemMedChem
Wright MH
(2014)
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
in Nature chemistry
Gong X
(2014)
Label-free in-flow detection of single DNA molecules using glass nanopipettes.
in Analytical chemistry
Braddock DC
(2014)
Studies towards the synthesis of halomon: asymmetric hexafunctionalisation of myrcene.
in Chemical communications (Cambridge, England)
Lovelock KR
(2014)
Vaporisation and thermal decomposition of dialkylimidazolium halide ion ionic liquids.
in Physical chemistry chemical physics : PCCP
Description | Chemistry is the study and application of the science at the molecular scale. It provides some of the most basic understandings of how the world works and underpins many modern technologies. It provides both the most mundane of objects, such as the disposable cup that holds you coffee, and the most vital compounds, such as life-saving drugs. Chemistry relies on four core instrumental techniques to study molecules; Nuclear Magnetic Resonance, Mass Spectrometry, X-Ray Crystallography and molecular scale Microscopy. This grant gave the Chemistry Department at Imperial College the ability to update these facilities. These have enabled research in all areas of Chemistry, for example the building of artificial cells, the production of fuels from biomass to the development of new potential pharmaceuticals and diagnostic techniques. There are too many to list. |
Exploitation Route | There are many ways in which these results can be put to use in the wider world. |
Sectors | Aerospace, Defence and Marine,Agriculture, Food and Drink,Chemicals,Energy,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Culture, Heritage, Museums and Collections,Pharmaceuticals and Medical Biotechnology,Security and Diplomacy,Transport |
Description | Policy Briefing Document |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Author of policy briefing document: Using Carbon Dioxide |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation to stakeholders |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Laura Barter was invited to the World Economic Forum in Davos to present her research investigating methods for increasing crop yields by promoting more efficient photosynthesis in the session on "Engineering Intelligent Food Systems". |
Year(s) Of Engagement Activity | 2018 |
Description | Radio Interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | BBC World Service's The Why Factor (8 February) on "Why is Water Exceptional?" |
Year(s) Of Engagement Activity | 2016 |
Description | Radio Interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Andrew Ashley interviewed on BBC Radio 4's Inside Science explaining his group's recent discovery in N2 fixation |
Year(s) Of Engagement Activity | 2016 |
Description | Schools activity |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Salters Festival of Chemistry: Annual Salters Festival. Y7 and Y8 many schools attend with their teachers to undertake two chemistry-based challenges |
Year(s) Of Engagement Activity | 2018 |
Description | Stakeholder meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Laura Barter, Rudiger Wolcholski and Sarah Al-Beidh organised a Creativity and Ideas generation event for the Sainsbury's farming scholars which was also attended by Sainsbury's horticulture manager, academics from Imperial, Natural History Museum and other UK institutions. Followed by attending the Annual Sainsbury's Farming Conference to highlight the success of the Sainsbury's Farming Scholars Programme - a recent collaboration between Imperial College, AGRI-net and Sainsbury's. |
Year(s) Of Engagement Activity | 2015,2016 |
Description | UK Chemicals Stakeholder Forum. Presentation on measuring sustainability |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Presentation and discussion on sustainability metrics |
Year(s) Of Engagement Activity | 2016 |
Description | World Economic Forum meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Prof David Klug introduced the "Hyperconnected Healthcare" panel at the World Economic Forum meeting in Dalian and participated as a panel member. |
Year(s) Of Engagement Activity | 2015 |