Underpinning Mechanistic Studies of NHC-Organocatalysis: A Breslow Intermediate Reactivity Scale
Lead Research Organisation:
University of St Andrews
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Zhu J
(2022)
The Role of the Fused Ring in Bicyclic Triazolium Organocatalysts: Kinetic, X-ray, and DFT Insights.
in The Journal of organic chemistry
Wang Y
(2022)
A Desilylative Approach to Alkyl Substituted C(1)-Ammonium Enolates: Application in Enantioselective [2+2] Cycloadditions.
in Angewandte Chemie (International ed. in English)
Wang Y
(2023)
Probing Regio- and Enantioselectivity in the Formal [2 + 2] Cycloaddition of C(1)-Alkyl Ammonium Enolates with ß- and a,ß-Substituted Trifluoromethylenones.
in The Journal of organic chemistry
Nimmo AJ
(2023)
Enantioselective isothiourea-catalysed reversible Michael addition of aryl esters to 2-benzylidene malononitriles.
in Chemical science
Duan Z
(2022)
Rate and equilibrium constants for the addition of triazolium salt derived N-heterocyclic carbenes to heteroaromatic aldehydes.
in Chemical science
Collett C
(2021)
Kinetic and Structure-Activity Studies of the Triazolium Ion- Catalyzed Intramolecular Stetter Reaction
in European Journal of Organic Chemistry
Abdelhamid Y
(2022)
Isothiourea-Catalyzed [2 + 2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins.
in Organic letters
Description | We have worked towards an understanding of a number of common reaction processes that use reactive organic compounds known as NHCs and demonstrated their utility in understanding reaction mechanisms. |
Exploitation Route | The understanding generated will be of widespread use within the synthesis and caltaysis communities, and may translate to large scale applications. IN particular, the understanding generated in this work will be able to be understood and applied by others leading to new reactivity. |
Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |