Molecules to Health Records
Lead Research Organisation:
Health Data Research UK
Department Name: UNLISTED
Abstract
Bringing together different types of information about patients and their diseases can lead to new ways to predict those at risk of getting them, prevent them from happening, detect them earlier to improve outcomes, and find new ways to treat them.
This programme will develop the new tools and science needed to bring together complex information from health records across the UK and beyond, together with genetic information and other detailed understandings of what changes are causing diseases to unlock these opportunities to improve the health and wellbeing of patients and the public.
This programme will develop the new tools and science needed to bring together complex information from health records across the UK and beyond, together with genetic information and other detailed understandings of what changes are causing diseases to unlock these opportunities to improve the health and wellbeing of patients and the public.
Technical Summary
This work is funded by the UKRI Medical Research Council, UKRI Engineering and Physical Sciences Research Council, UKRI Economic and Social Research Council, Department of Health and Social Care, National Institute for Health Research (England), Chief Scientist Office (Scottish Government), Health and Care Research Wales, Public Health Agency HSC (Northern Ireland), British Heart Foundation and Cancer Research UK
The programme’s vision is to create new informatics infrastructures and data science methods that help achieve a deep integration of biology, biomedicine and population health sciences to gain major new insights into the underlying causes and biology of diseases by bringing together on a grand scale multimodal information on genomics, other molecular traits, and high-resolution electronic health records (EHRs). The ‘Molecules to Health Records’ approach will help unlock the potential of major global investments in large-scale molecular bioresources of populations and patients.
Objectives
The priority areas of focus include:
1. Molecular underpinnings of multi-disease aetiology, aligned with the strategic aims of the Medical Research Council (MRC) and National Institute for Health Research (NIHR).
2. Therapeutic target prioritisation, aligned with the MRC’s strategic aim to enhance therapeutic target validation and promote collaboration with industry across both common and rare diseases.
3. Genomic causes of rare disorders, aligned with the UK Strategy for Rare Diseases and Genome UK.
4. Risk prediction and stratified prevention, aligned with MRC and the UK Prevention Research Partnership’s and Genome UK’s strategic aim to enhance prevention and early detection of common diseases.
Impact and legacy
This programme’s distinctive contribution is, therefore, to help develop approaches and infrastructuresthat realise novel insights from EHR-enabled bioresources, working across cohorts to maximise scale, synergy and diversity. This proposal aims to seize opportunities that HDR UK is uniquely positioned to deliver, and achieve a balance of risk and reward, scale and agility, infrastructure development and tangible research outputs. This programme will contribute to HDR UK’s key cross-cutting ambitions, including addressing inequalities (e.g., through creation of genomic medicine tools in diverse non-European populations), developing synergistic approaches to disease prevention (e.g., through multi-omic studies of multi-disease aetiology), and promoting resilience against future health shocks (e.g., through mobilisation and multipurpose use of global populations cohorts for communicable and non-communicable disease epidemiology).
The programme’s vision is to create new informatics infrastructures and data science methods that help achieve a deep integration of biology, biomedicine and population health sciences to gain major new insights into the underlying causes and biology of diseases by bringing together on a grand scale multimodal information on genomics, other molecular traits, and high-resolution electronic health records (EHRs). The ‘Molecules to Health Records’ approach will help unlock the potential of major global investments in large-scale molecular bioresources of populations and patients.
Objectives
The priority areas of focus include:
1. Molecular underpinnings of multi-disease aetiology, aligned with the strategic aims of the Medical Research Council (MRC) and National Institute for Health Research (NIHR).
2. Therapeutic target prioritisation, aligned with the MRC’s strategic aim to enhance therapeutic target validation and promote collaboration with industry across both common and rare diseases.
3. Genomic causes of rare disorders, aligned with the UK Strategy for Rare Diseases and Genome UK.
4. Risk prediction and stratified prevention, aligned with MRC and the UK Prevention Research Partnership’s and Genome UK’s strategic aim to enhance prevention and early detection of common diseases.
Impact and legacy
This programme’s distinctive contribution is, therefore, to help develop approaches and infrastructuresthat realise novel insights from EHR-enabled bioresources, working across cohorts to maximise scale, synergy and diversity. This proposal aims to seize opportunities that HDR UK is uniquely positioned to deliver, and achieve a balance of risk and reward, scale and agility, infrastructure development and tangible research outputs. This programme will contribute to HDR UK’s key cross-cutting ambitions, including addressing inequalities (e.g., through creation of genomic medicine tools in diverse non-European populations), developing synergistic approaches to disease prevention (e.g., through multi-omic studies of multi-disease aetiology), and promoting resilience against future health shocks (e.g., through mobilisation and multipurpose use of global populations cohorts for communicable and non-communicable disease epidemiology).
Organisations
- Health Data Research UK (Lead Research Organisation)
- UNIVERSITY OF YORK (Collaboration)
- Addis Ababa University (Collaboration)
- National Heart Foundation of Bangladesh (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- University of Glasgow (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Homi Bhabha National Institute (Collaboration)
- Nightingale Health Ltd. (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- University of Oxford (Collaboration)
- Baker IDI Heart and Diabetes Institute (Collaboration)
- University College London (Collaboration)
- AstraZeneca (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- University of Sheffield (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- Public Health Scotland (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (Collaboration)
- Tata Memorial Hospital (Collaboration)
- Bradford Teaching Hospitals NHS Foundation Trust (Collaboration)
- Regeneron Pharmaceuticals, Inc. (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- HEALTH DATA RESEARCH UK (Collaboration)
- National Institute for Health and Care Excellence (NICE) (Collaboration)
- University of Bristol (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- University of Edinburgh (Collaboration)
- SWANSEA UNIVERSITY (Collaboration)
- UNIVERSITY OF DUNDEE (Collaboration)
Publications
Addey T
(2023)
Educational and social inequalities and cause-specific mortality in Mexico City: a prospective study
in The Lancet Public Health
Akbari P
(2023)
A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.
in Nature communications
Allara E
(2024)
Novel loci and biomedical consequences of iron homoeostasis variation.
in Communications biology
Aung N
(2023)
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
in JAMA cardiology
Barclay M
(2023)
Phenotypes and rates of cancer-relevant symptoms and tests in the year before cancer diagnosis in UK Biobank and CPRD Gold.
in PLOS digital health
Bassett E
(2024)
Inconsistency in UK Biobank Event Definitions From Different Data Sources and Its Impact on Bias and Generalizability: A Case Study of Venous Thromboembolism
in American Journal of Epidemiology
Bohrmann B
(2023)
Body Mass Index and Risk of Hospitalization or Death Due to Lower or Upper Respiratory Tract Infection.
in JAMA
Bouza L
(2023)
How to estimate carbon footprint when training deep learning models? A guide and review.
in Environmental research communications
Bragg F
(2024)
Social and spatial inequalities in premature mortality across Europe.
in The Lancet. Public health
| Description | AI&Climate funding - Loic Lannelongue |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| Impact | All the AI&Climate funding calls from France 2030 (French National Strategic Funding coordinated by the French government) now requires an estimation of the carbon footprint of the AI solution proposed, and this estimate has to be obtained using our Green Algorithms online calculator. |
| URL | https://zenodo.org/records/14607021 |
| Guideline Title | SCORE2 |
| Description | Availability of the updated new health risk calculator SCORE2 an help prevent heart attacks and strokes in people with type 2 diabetes. |
| Geographic Reach | Europe |
| Policy Influence Type | Citation in clinical guidelines |
| URL | https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/CVD-and-Diabetes-Guidelines |
| Description | Contributed to several workshop with UKRI and the Wellcome Trust to shape their sustainable funding policies. Loic Lannelongue |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Data for Cancer Risk - Scientific Consultation Workshop (John Danesh) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Fundamentals of Statistical Software and Analysis (FoSSA) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Nearly 2000 participants from around the globe are enrolled on the free FoSSA course to gain statistical training, and the FoSSA course has been translated into French and won awards. |
| URL | https://www.medsci.ox.ac.uk/study/skills-training/calendar/fundamentals-of-statistical-software-and-... |
| Description | Heidelberg Agreement on Environmental Sustainability in Research Funding - Loic Lannelongue |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | "Heidelberg Agreement on Environmental Sustainability in Research Funding", calls for funders to set ambitious sustainability goals; share principles for approaching sustainability in research funding based on innovation, experimentation, partnership, diversity and co-creation; highlight the importance of sustainability in their schemes; and support the development and adoption of tools that help researchers to integrate sustainability. In the UK, the document has been endorsed by UKRI, the MRC and the Wellcome Trust. |
| URL | https://zenodo.org/records/13938809 |
| Description | Part of the expert advisory board for the UKRI Net Zero Digitar Research Infrastrure scoping project. Loic Lannelongue |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Requirement by the French DEFRA to use our Green Algorithms calculator to apply to one of their AI funding calls. Loic Lannelongue |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Teaching on MPhil course, Research Skills MPhil PHS, Applying for research funding module |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Researchers knowledge related to applying for research funding has increased. |
| Description | Teaching on MPhil course, grant application module |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | WHO Global Consultation on Monkeypox (John Danesh) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | green DiSC sustainability certification |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Green DiSC is a new certification scheme which provides a roadmap for research groups and institutions who want to tackle the environmental impacts of their computing activities. Too early to demonstrate benefits. |
| URL | https://www.software.ac.uk/GreenDiSC |
| Description | publication of a report commissioned by the UK DSIT and DCMS on the environmental impacts of the UK Digital Sector |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Loic led the publication of a report commissioned by the UK DSIT and DCMS on the environmental impacts of the UK Digital Sector, and participated in dissemination events with civil servants. Too early to talk about the benefits. |
| URL | https://zenodo.org/records/14831758 |
| Description | ADVANCING PRIMARY PREVENTION STRATEGIES FOR COMPLEX DISEASES |
| Amount | £73,459 (GBP) |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | Artificial intelligence systems to improve the safety, efficiency and clinical outcomes of blood transfusion by the precise genetic matching of patients to blood units |
| Amount | £1,026,551 (GBP) |
| Funding ID | AI_AWARD02331 |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 02/2025 |
| Description | BRC 2022-2027 Data Science and Population Health |
| Amount | £86,000,000 (GBP) |
| Funding ID | NIHR203312 |
| Organisation | Cambridge University Hospitals NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 11/2027 |
| Description | British Heart Foundation (BHF): - BHF, Centre of Excellence - Pump Priming (Adam Butterworth) (£ 41000; 2019 - 2024) |
| Amount | £6,000,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2024 |
| Description | British Heart Foundation (BHF): - BHF, Centre of Excellence - Pump Priming (Adam Butterworth) (£ 50000; 2019 - 2024) |
| Amount | £6,000,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2024 |
| Description | British Heart Foundation (BHF): - BHF, Centre of Excellence - Pump Priming (Seamus Harrison) (£ 116735; 2020 - 2023) |
| Amount | £116,735 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 12/2023 |
| Description | Concomitant primary prevention of multiple chronic diseases through data-driven approaches mobilising population-wide longitudinal health records. |
| Amount | £1,958,101 (GBP) |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2023 |
| End | 11/2028 |
| Description | EFFICIENT AI TOOLS FOR EQUITABLE HANDLING OF MISSING VALUES IN POPULATION -WIDE E_HEALTH RECORDS TO ADVANCE PREVENTION OF CHRONIC DISEASE |
| Amount | £605,720 (GBP) |
| Funding ID | G122409 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 03/2025 |
| Description | Genetic, behavioural and clinical predictors of suboptimal response to statin therapy: a pilot study |
| Amount | £26,534 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2023 |
| End | 09/2024 |
| Description | Identifying preventative opportunities for coronary heart disease and stroke in multi-ancestry patients with non-cardiovascular conditions |
| Amount | £336,368 (GBP) |
| Funding ID | R2071CNR - Allara |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2028 |
| Description | Impact of COVID-19 on the association between Type 2 diabetes and incidence of cardiovascular diseases |
| Amount | £49,928 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 04/2024 |
| Description | Integrating genomic, multi-omic and clinical data at population scale to inform therapeutic targets and drug development programmes |
| Amount | £104,224 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2027 |
| Description | Integration of polygenic risk scores and clinical data into an open platform that enables pragmatic trials |
| Amount | £660,053 (GBP) |
| Funding ID | 227566/Z/23/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 09/2028 |
| Description | Investigating transportablility of cancer detection models across datasets and time using population-wide electronic health data |
| Amount | £90,175 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2023 |
| Description | Large-scale integrative molecular studies of CVDs in multi-ethnic cohorts |
| Amount | £1,749,971 (GBP) |
| Funding ID | RG/F/23/110103 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2024 |
| End | 02/2029 |
| Description | Longitudinal metabolomic profiles and cardiometabolic diseases |
| Amount | £49,950 (GBP) |
| Funding ID | RG96157 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 09/2024 |
| Description | Multimorbidity Mechanism and Therapeutics Research Collaborative |
| Amount | £3,015,658 (GBP) |
| Funding ID | MR/V033867/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 03/2025 |
| Description | PhD Studentship (HB) |
| Amount | £90,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2027 |
| Description | Professor Emanuele Di Angelantonio |
| Amount | £80,000 (GBP) |
| Funding ID | NIHR203769 |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2026 |
| Description | Research Excellence (round 3) |
| Amount | £6,000,000 (GBP) |
| Funding ID | RE/18/1/34212 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2024 |
| Description | Strengthening community knowledge bases for genetic association studies and polygenic scores, the GWAS and PGS Catalogs |
| Amount | $5,400,000 (USD) |
| Organisation | European Molecular Biology Laboratory |
| Sector | Academic/University |
| Country | Germany |
| Start | 06/2022 |
| End | 06/2027 |
| Description | Studentship: HDR UK Turing PhD Programme in Health Data Science - (Student Details form for Mary Chriselda Antony OLIVER) |
| Amount | £155,200 (GBP) |
| Funding ID | HDRUK2022.0235-OLIVER |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | Studentship: HDR UK Turing PhD Programme in Health Data Science - (Student Details form for Robert FLETCHER) |
| Amount | £155,200 (GBP) |
| Funding ID | HDRUK2022.0234-FLETCHER |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | The BHF Chair of Epidemiology and Medicine |
| Amount | £1,609,758 (GBP) |
| Funding ID | CH/12/2/29428 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 04/2027 |
| Description | The CAPABLE longitudinal study of non-communicable diseases |
| Amount | £93,797 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 03/2023 |
| Description | The effect of the COVID-19 pandemic on outcomes in pregnant women with pre-existing cardiovascular disease |
| Amount | £49,070 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 04/2024 |
| Description | The first England-wide study of pregnant women with pre-existing heart disease: the impact of COVID-19 diagnosis and vaccination |
| Amount | £49,070 (GBP) |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 04/2024 |
| Description | Translational proteomics for cardiovascular diseases: from population prediction to clinical and therapeutic applications (Prot4CVD) (joint funding with DZHK and DHF) |
| Amount | £490,874 (GBP) |
| Funding ID | SP/F/23/150048 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2027 |
| Description | Understanding the relationship between diabetes and the development of multiple long-term conditions in Scotland, England and Wales |
| Amount | £276,496 (GBP) |
| Funding ID | R2071CNR - Cezard |
| Organisation | Health Data Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2028 |
| Description | Validation of SCORE2 10-year cardiovascular disease risk prediction models before and after the Covid-19 pandemic in the population of England |
| Amount | £49,228 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 04/2024 |
| Description | Xiyun Jiang PhD Studentship |
| Amount | £156,323 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Title | Imaging genomics dashboard |
| Description | As part of our work on integrating neuroimaging and genetics we developed a searchable and interactive dashboard to visualise output from various imaging related genome wide association studies. We are currently in testing stage, but hoping to make it available to the general public within the next 6 months. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2025 |
| Provided To Others? | No |
| Impact | It will allow us to share outcomes, data and results in an interactive manner alongside forthcoming research publications. |
| Title | Blood Donors Studies BioResource (Emanuele Di Angelantonio) |
| Description | We have collated participant-consented data from our blood donor studies, along with electronic health records, and created the Blood Donors Studies BioResource [Research Database] (REC reference: 20/EE/0115). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The BioResource contains a large amount of data (planned size is up to 325,000 participants) and different kinds of data (questionnaire, blood donation records, physical activity, cognitive function, blood traits, multi-'omics, sequencing) and participant data has been linked to electronic health record data. The aim is to enable research into the associations of genetic, biological, lifestyle and other exposures with health outcomes in a large and richly characterised cohort of healthy volunteers. We have a robust Data Access Policy (see link below) to enable access to the data for suitable research projects. |
| URL | http://www.donorhealth-btru.nihr.ac.uk/project/bioresource |
| Title | Green Algorithms (Mike Inouye) |
| Description | The algorithm on the website allows a researcher to calculate how green are their computations. There is information about how to interpret the results and suggestions for how to be "more green". The project was featured on the HDR UK website (www.hdruk.ac.uk/news/green-algorithms-for-health-data-science). |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The resource is relatively new, so no notable impact yet. |
| URL | http://www.green-algorithms.org |
| Title | OMICSPRED (Mike Inouye) |
| Description | OMICSPRED is a resource for predicting multi-'omics data (proteomics, metabolomics, transcriptomics, etc.) directly from genotypes. To do this, we have used a single cohort (the INTERVAL study: www.intervalstudy.org.uk) with extensive multi-'omics data to train genetic scores using machine learning. You can explore and download the genetic scores for a wide range of biomolecular traits in human blood as well as the summary statistics of their associations with key traits and diseases in the UK Biobank. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | The OMICSPRED website is open and accessible, and visited by 588 users per month on average over the last year (February 2023-Feburary 2024). Over the same time period there have been 1523 downloads of the OMICSPRED scores from our file server, and there has been one preprint (Drozd et al. medRxiv 2024) |
| URL | https://www.omicspred.org |
| Title | Participant follow-up questionnaire data - continuing in 2025 |
| Description | The study investigators are currently conducting the next round of follow-up with approximately ~75,000 participants. Follow-up involves participants completing a telephone-based questionnaire, providing responses about whether their health status or health system usage has changed since the previous round of follow-up, which was completed in 2022. Incoming follow-up questionnaire responses continue to be stored in a database for future research use. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | There is limited research on the incidence of non-communicable diseases in the South Asian population when compared to the data linked to persons with European ancestry. Therefore, a notable impact of the follow-up works is the expansion of incidence data available to future analysts |
| Title | Polygenic Score Catalog |
| Description | The Polygenic Score (PGS) Catalog (pgscatalog.org), which is co-led by CEU and other Cambridge-based researchers. It is still version 1 but may be useful to the research of many right now. So far, there are 34 polygenic scores, 12 traits cataloged and this will grow rapidly in the near future. Huge credit goes to Sam Lambert (CEU/CBSGI) and Jackie MacArthur (EMBL-EBI) for co-leading this effort. Many additional contributions from CEU came from Jonathan Maarten, Petar Scepanovic, Gad Abraham, and John Danesh. --- Key points --- Twitter handle: @PGSCatalog First tweet: https://twitter.com/PGSCatalog/status/1183887639654612992?s=20 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Version 1 just released - impact yet to arise |
| URL | http://pgscatalog.org/ |
| Title | STRIDES BioResource (Emanuele Di Angelantonio) |
| Description | STRIDES is a study aiming to improve donor experiences within National Health Service Blood and Transplant (NHSBT). With over 1 million people donating around 1.6 million whole blood units every year, NHSBT is conducting world-leading research into donor management and, through academic partnerships, addressing wider public health issues. Additional biological, genetic and questionnaire data has been collected on approximately 70,000 participants. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Study has ended and analysis is ongoing, so no impact yet. |
| URL | http://www.strides-study.org.uk |
| Title | TRACK-COVID (Emanuele Di Angelantonio) |
| Description | To provide scientists and national decision-makers with detailed information to help control and understand the novel coronavirus pandemic ("COVID-19"), this study tracks over 20,000 individuals across England during the coming the year or so. Individuals who participated in the INTERVAL, COMPARE or STRIDES BioResource studies will be invited to take part. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The TRACK-COVID study is participating in to further COVID-19 research. This initiative is the UK Longitudinal Linkage Collaboration (UK LLC). The UK LLC initiative is creating a research database containing data on millions of people from many UK studies including the TRACK-COVID study. The initiative has been set-up in response to the coronavirus pandemic to enable investigation into high priority COVID-19 research questions and to inform public health policy. The research database will be a safe place in which the data from these studies can be stored, organised and analysed by approved UK-based researchers. This research programme looks at the big picture which includes COVID-19 itself, but also the impact that lockdown and other restrictions have had on wider health (such as mental health or cancer care), education and families. |
| URL | https://www.trackcovid.org.uk |
| Description | Alliance for Medical Research in Africa (AMEDRA) Collaboration (JC) |
| Organisation | Addis Ababa University |
| Country | Ethiopia |
| Sector | Academic/University |
| PI Contribution | Collaborative meetings, harmonisation of data and analyses. |
| Collaborator Contribution | Collaborative meetings, harmonisation of data and analyses. |
| Impact | The harmonisation and analysis of 40 cross-sectional studies (N=200K) and five prospective studies (N=20K) across Africa as part of the African Studies on Non-Communicable Diseases (ASANDE) Consortium will lead to a variety of capacity building exercises over the next few years. |
| Start Year | 2025 |
| Description | Astra Zeneca |
| Organisation | AstraZeneca |
| Department | Astra Zeneca |
| Country | United States |
| Sector | Private |
| PI Contribution | Joint PhD Student (Nick Hirschmuller). PhD sits at University of Cambridge |
| Collaborator Contribution | The PhD Student is spending 50% of their time embedded within the Centre for Genomics Research at AstraZeneca, and they will receive day-to-day training and supervision from other team members at Astra Zeneca. |
| Impact | None yet |
| Start Year | 2023 |
| Description | BELIEVE |
| Organisation | National Heart Foundation of Bangladesh |
| Country | Bangladesh |
| Sector | Charity/Non Profit |
| PI Contribution | Funding, protocol design and implementation support; analysis of data and publication manuscript preparation. Scientific leadership. |
| Collaborator Contribution | Conduct of the protocol, use of resources and sample/data transport |
| Impact | N/A - commenced 2016 |
| Start Year | 2016 |
| Description | Co-connect |
| Organisation | Health Data Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Oxford University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Public Health Scotland |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Dundee |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Edinburgh |
| Department | Edinburgh Genomics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Co-connect |
| Organisation | University of Sheffield |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing expertise and data curation |
| Collaborator Contribution | WP1: PPIE WP2:Determine which data fields need to be captured to answer the key research questions and then work with labs across the UK, LIMS providers and data sources to modify processes and systems to capture this additional data. WP3: Leveraging and connecting different existing components of infrastructure and automating the data flows between them. WP4: Data Curation |
| Impact | None yet |
| Start Year | 2020 |
| Description | Exploring the genetic determinants of molecular and complex traits in a continental African population |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of statistical genetic methods. |
| Collaborator Contribution | Genetic data, ferritin measurement and metabolic biomarker profiling of Uganda individuals. Application of statistical genetic methods. |
| Impact | None yet |
| Start Year | 2024 |
| Description | Genomic Medicine collaboration |
| Organisation | The Wellcome Trust Sanger Institute |
| Department | Human Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration forms a work-stream in the HDR UK Molecules to Health Records driver programme, and aims to understand causes of neurodevelopmental disorders better. I provide overall leadership for the programme. |
| Collaborator Contribution | The collaboration comprises researchers from the University of Oxford (led by Professor Stephan Sanders), the Wellcome Sanger Institute (led by Professor Matt Hurles), UCL (led by Professor Ruth Gilbert), and the University of Cambridge (led by Dr Richard Bethlehem). These partners bring multi-disciplinary expertise (described below), as well as leadership of specific data resources that will be used for this research (e.g. ECHILD, Deciphering Developmental Disorders, NHS neuro-imaging data). All partners will contribute to creating a novel, multi-dimensional data resource, and the analysis of these data. |
| Impact | No outcomes thus far. The collaboration is multi-disciplinary, comprising: Sanders group - paediatric neurogenetics Hurles group - genetics of developmental disorders Gilbert group - social epidemiology Bethlehem group - neuroinformatics and neuroimaging |
| Start Year | 2023 |
| Description | Genomic Medicine collaboration |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration forms a work-stream in the HDR UK Molecules to Health Records driver programme, and aims to understand causes of neurodevelopmental disorders better. I provide overall leadership for the programme. |
| Collaborator Contribution | The collaboration comprises researchers from the University of Oxford (led by Professor Stephan Sanders), the Wellcome Sanger Institute (led by Professor Matt Hurles), UCL (led by Professor Ruth Gilbert), and the University of Cambridge (led by Dr Richard Bethlehem). These partners bring multi-disciplinary expertise (described below), as well as leadership of specific data resources that will be used for this research (e.g. ECHILD, Deciphering Developmental Disorders, NHS neuro-imaging data). All partners will contribute to creating a novel, multi-dimensional data resource, and the analysis of these data. |
| Impact | No outcomes thus far. The collaboration is multi-disciplinary, comprising: Sanders group - paediatric neurogenetics Hurles group - genetics of developmental disorders Gilbert group - social epidemiology Bethlehem group - neuroinformatics and neuroimaging |
| Start Year | 2023 |
| Description | Genomic Medicine collaboration |
| Organisation | University of Cambridge |
| Department | Department of Psychology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration forms a work-stream in the HDR UK Molecules to Health Records driver programme, and aims to understand causes of neurodevelopmental disorders better. I provide overall leadership for the programme. |
| Collaborator Contribution | The collaboration comprises researchers from the University of Oxford (led by Professor Stephan Sanders), the Wellcome Sanger Institute (led by Professor Matt Hurles), UCL (led by Professor Ruth Gilbert), and the University of Cambridge (led by Dr Richard Bethlehem). These partners bring multi-disciplinary expertise (described below), as well as leadership of specific data resources that will be used for this research (e.g. ECHILD, Deciphering Developmental Disorders, NHS neuro-imaging data). All partners will contribute to creating a novel, multi-dimensional data resource, and the analysis of these data. |
| Impact | No outcomes thus far. The collaboration is multi-disciplinary, comprising: Sanders group - paediatric neurogenetics Hurles group - genetics of developmental disorders Gilbert group - social epidemiology Bethlehem group - neuroinformatics and neuroimaging |
| Start Year | 2023 |
| Description | Genomic Medicine collaboration |
| Organisation | University of Oxford |
| Department | Department of Paediatrics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration forms a work-stream in the HDR UK Molecules to Health Records driver programme, and aims to understand causes of neurodevelopmental disorders better. I provide overall leadership for the programme. |
| Collaborator Contribution | The collaboration comprises researchers from the University of Oxford (led by Professor Stephan Sanders), the Wellcome Sanger Institute (led by Professor Matt Hurles), UCL (led by Professor Ruth Gilbert), and the University of Cambridge (led by Dr Richard Bethlehem). These partners bring multi-disciplinary expertise (described below), as well as leadership of specific data resources that will be used for this research (e.g. ECHILD, Deciphering Developmental Disorders, NHS neuro-imaging data). All partners will contribute to creating a novel, multi-dimensional data resource, and the analysis of these data. |
| Impact | No outcomes thus far. The collaboration is multi-disciplinary, comprising: Sanders group - paediatric neurogenetics Hurles group - genetics of developmental disorders Gilbert group - social epidemiology Bethlehem group - neuroinformatics and neuroimaging |
| Start Year | 2023 |
| Description | Indian Health Aging Study (ISHA) - Barshi |
| Organisation | Homi Bhabha National Institute |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Scientific and project management. |
| Collaborator Contribution | Project Management and data collection. |
| Impact | Data generation and a joint publication. |
| Start Year | 2015 |
| Description | Indian Health Aging Study (ISHA) - Barshi |
| Organisation | Tata Memorial Hospital |
| Country | India |
| Sector | Hospitals |
| PI Contribution | Scientific and project management. |
| Collaborator Contribution | Project Management and data collection. |
| Impact | Data generation and a joint publication. |
| Start Year | 2015 |
| Description | Multi-omics consortium |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Multi-omics consortium |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Multi-omics consortium |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Multi-omics consortium |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Multi-omics consortium |
| Organisation | University of Dundee |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Multi-omics consortium |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, and populations cohorts totalling 80,000 participants that have been densely genotyped and phenotyped and are linked to electronic health records. |
| Collaborator Contribution | Partners will bring scientific domain knowledge, epidemilogical and statistical skills and capacity, infrastructural computing expertise, and populations cohortsthat have been densely genotyped and phenotyped and are linked to electronic health records. |
| Impact | The multi-omics consortium has been awarded £1.1M through HDR UK. |
| Start Year | 2019 |
| Description | Nightingale Collaboration |
| Organisation | Nightingale Health Ltd. |
| Country | Finland |
| Sector | Private |
| PI Contribution | Collaboration with Nightingale Health Ltd enabled us to increase data for our analysts, providing strategic and analytical input. The agreement has been extended early 2024 to enter the third phase of the agreement, i.e. assay data for the approximately 220,000 samples analysed in Nightingale's UK Biobank project. |
| Collaborator Contribution | Nightingale health provided lab support and Bristol shared strategic and analytical input. |
| Impact | No outputs to date |
| Start Year | 2020 |
| Description | Nightingale Collaboration |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Nightingale Health Ltd enabled us to increase data for our analysts, providing strategic and analytical input. The agreement has been extended early 2024 to enter the third phase of the agreement, i.e. assay data for the approximately 220,000 samples analysed in Nightingale's UK Biobank project. |
| Collaborator Contribution | Nightingale health provided lab support and Bristol shared strategic and analytical input. |
| Impact | No outputs to date |
| Start Year | 2020 |
| Description | PGS Catalog |
| Organisation | Baker IDI Heart and Diabetes Institute |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Intellectual input to create a polgenic score catalogue has been led by Dr Inouye, support by Dr Lambert. Dr Lambert produced a prototype catalogue. |
| Collaborator Contribution | The Wellcome Sanger Institute has funded a software developer to enhance and expand the polygenic score catalog. EBI have provided intellectual input, curation capacity and infrastructure (e.g. the Embassy Cloud for hosting the catalogue). |
| Impact | A polgenic score catalog has been developed: http://www.pgscatalog.org/ |
| Start Year | 2019 |
| Description | PGS Catalog |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Intellectual input to create a polgenic score catalogue has been led by Dr Inouye, support by Dr Lambert. Dr Lambert produced a prototype catalogue. |
| Collaborator Contribution | The Wellcome Sanger Institute has funded a software developer to enhance and expand the polygenic score catalog. EBI have provided intellectual input, curation capacity and infrastructure (e.g. the Embassy Cloud for hosting the catalogue). |
| Impact | A polgenic score catalog has been developed: http://www.pgscatalog.org/ |
| Start Year | 2019 |
| Description | PGS Catalog |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Intellectual input to create a polgenic score catalogue has been led by Dr Inouye, support by Dr Lambert. Dr Lambert produced a prototype catalogue. |
| Collaborator Contribution | The Wellcome Sanger Institute has funded a software developer to enhance and expand the polygenic score catalog. EBI have provided intellectual input, curation capacity and infrastructure (e.g. the Embassy Cloud for hosting the catalogue). |
| Impact | A polgenic score catalog has been developed: http://www.pgscatalog.org/ |
| Start Year | 2019 |
| Description | Regeneron |
| Organisation | Regeneron Pharmaceuticals, Inc. |
| Country | United States |
| Sector | Private |
| PI Contribution | Providing samples from Asian cohorts |
| Collaborator Contribution | Whole exome genotyping on samples from Asian cohorts. |
| Impact | none yet |
| Start Year | 2019 |
| Description | UCl Convalesence Long Covid |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | National Institute for Health and Care Excellence (NICE) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Description | UCl Convalesence Long Covid |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in analysis of national electronic health records |
| Collaborator Contribution | HDR-UK research sites and SAIL with expertise in analysis of national electronic health records (Brophy, Denaxas, Macleod, Sterne, Wood, (Hemingway and Lyons as collaborators)), THIN data enhanced with free text (Shah) and leaders of the OpenSAFELY platform (Goldacre, Smeeth). Leaders of vanguard population cohorts (Chaturvedi (NSHD, SABRE), Ploubidis (Centre for Longitudinal Studies, (Goodman, Fitzsimmons and Calderwood as collaborators)), Porteus (Generation Scotland), Steptoe (ELSA), Steves (TwinsUK), Timpson (ALSPAC) and Wright/McEachan (Born in Bradford). Benzeval (lead of Understanding Society) and Katikireddi (Understanding Society data super user) are collaborators. Statistical collaborative expertise includes Tilling (Bristol) and Silverwood (UCL). Experts in wearables and remote testing in large population studies (Dobson, Folarin) Imaging expertise from Hughes (in large population studies including SABRE, NSHD and ALSPAC), and Raman (PHOSP CMORE) (with collaboration from Neubauer (PHOSP C-MORE) and PHOSP itself (Brightling PI) Expertise in qualitative research, engagement and co-production (Carpentieri, Sheard, McEachan) NICE Director of Science, Evidence & Analytics (Greaves) |
| Impact | None yet |
| Start Year | 2021 |
| Title | Nightingale Health Dried Blood Spot Testing Kits - Pilot Study |
| Description | Nightingale Health (a biotechnology company based in Helsinki, Finland), have produced a dried blood spot finger-prick test which can be analysed using their unique high-throughput nuclear magnetic resonance (NMR) platform to capture 249 metabolic measurements, including biomarker measures associated with cardiometabolic disease. The platform also allows the generation of biomarker 'scores', which can be used to predict cardiovascular events, type 2 diabetes, and all-cause mortality. The BELIEVE-Urban study group will assess the effectiveness and feasibility of collecting dried blood spots in a Bangladeshi context on a small pilot-scale. This pilot will be integrated into existing follow-up and household visit procedures in two phases and if successful, and subject to funding opportunities, the study group will extend the collection of dried blood spots to a larger scale (i.e., blood spots would be collected for all consenting BELIEVE Urban study participants). This testing approach would then be used on a repeated basis to collect longitudinal blood samples during follow-up. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2025 |
| Development Status | Under active development/distribution |
| Impact | No impact yet |
| URL | https://nightingalehealth.com/for-research |
| Title | PGScatalog/pgsc_calc: pgsc_calc v1.3.0 |
| Description | pgsc_calc is a bioinformatics best-practice analysis pipeline for calculating polygenic [risk] scores (PGS) on samples with imputed genotypes using existing scoring files from the PGS Catalog (www.PGSCatalog.org) and/or user-defined PGS/PRS. The calculator workflow is implemented in nextflow (a common tool for creating and running bioinformatics workflows), and automates PGS downloads from the Catalog, variant matching between scoring files and target genotyping samplesets, and the parallel calculation of multiple PGS in a computationally efficient manner. |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| Impact | The calculator is a fully-automated and open-source pipeline to calculate polygenic scores on common genotype data formats. The pipeline doesn't require specialist bioinformatics skills to run, abstracting complicated and time-consuming variant matching steps, and only requires users to write a small sample description file and have basic knowledge of the command line. This simplicity allows a broader userbase to calculate and apply polygenic scores for research or clinical applications. Our userbase is growing and consists of: - 48 Github users (tracking repository updates and engaging with development by opening issues). *This is likely an underestimate, as we have only started tracking Github downloads in 2023 due to limitations of code hosting service. - Worldwide reach including users from: Canada, USA, Australia, China. The userbase includes clinicians and researchers primarily from academia; however some companies are using the pipeline as well. - From October 1, 2022 - December 31, 2022 there were 2445 PGS Catalog API requests through the pipeline. |
| URL | https://github.com/PGScatalog/pgsc_calc |
| Description | "DNA arts and crafts: Hands-on genetic risk scores" Family day stall at Cambridge Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | DNA arts and crafts hands-on educational event for 1 day. Participants got to score your sequence for risk of heart disease.This hands-on activity involved designing a new DNA sequence with a variety of art materials. Like genetic researchers, participants compared the DNA sequence they made to known sequences to see if they could spot any future heart problems. This opened up a conversation on what life choices you can make to prevent heart disease. |
| Year(s) Of Engagement Activity | 2023 |
| Description | "DNA arts and crafts: Hands-on genetic risk scores" Family day stall at Cambridge Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | An experiential science education activity integrated in a community event for families in the summer holiday (Cambridge Football club). The community setting meant that families who might not go to science festivals in universities have easy access. DNA arts and crafts hands-on educational event for 1 day. Participants got to score your sequence for risk of heart disease.This hands-on activity involved designing a new DNA sequence with a variety of art materials. Like genetic researchers, participants compared the DNA sequence they made to known sequences to see if they could spot any future heart problems. This opened up a conversation on what life choices you can make to prevent heart disease. Did the public understand the activity: The majority did. Some understood it well enough to ask some very high level questions, about how risk may differ across families or whether there were DNA studies they could join at Cambridge that would give more insight into their own genetic disease. Did they learn anything from the activity: The majority did. Often the parents asked as many questions as the children, so it was clearly good at engaging the whole family. Several said that they found the science very interesting. Will they do anything different as a result of taking part in our activity? |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://abbeypeople.org.uk/eager-explorers/ |
| Description | "Presenting at Research Symposium "Human Proteome and Health" by Oxford Population Health, Oxford UK" Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting on 'Proteomics in diverse populations' at Research Symposium "Human Proteome and Health" by Oxford Population Health, Oxford UK |
| Year(s) Of Engagement Activity | 2023 |
| Description | - BHF CRE Annual Research Symposium 2023 and SAB Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual Research Symposium |
| Year(s) Of Engagement Activity | 2023 |
| Description | 2023 ESC Congress - Clinical Practice Guidelines, Amsterdam. Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "The ESC is a world leader in the discovery and dissemination of best practices in cardiovascular medicine. It is a volunteer-led, not-for-profit medical society. Members and decision-makers are scientists, clinicians, nurses and allied professionals working in all fields of cardiology. Emanuele was there in his capacity as an EAPC Board member to meet with international collaborators to discuss and develop discuss Clinical Practice Guidelines and Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes. He presented on 'Methodology part II overview - LoE for prediction tools, risk scores, and diagnostic strategies' at the Clinical Practice Guidelines Committee Meeting" |
| Year(s) Of Engagement Activity | 2023 |
| Description | 2023 NHSBT Clinical and R&D Conference in Birmingham, UK Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The theme of this Conference was 'Tackling Health Inequalities' and Emanuele presented on Donor Health & Behaviour. The BTRUs are fundamental to delivering NHSBT's research priorities and this was an opportunity to showcase the work of the research units. |
| Year(s) Of Engagement Activity | 2023 |
| Description | A short talk at HDR UK Oxford Regional Meeting (JT) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A short talk at HDR UK Oxford Regional Meeting: Genetic Prediction of the metabolome in an admixed Mexican population |
| Year(s) Of Engagement Activity | 2024 |
| Description | A talk as part of a panel and a poster presentation at the CROSCIENCE 2024 Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk as part of a panel poster presentation at the CROSCIENCE 2024 Symposium: Fat mass and the blood plasma proteome |
| Year(s) Of Engagement Activity | 2024 |
| Description | A talk: How to make the most of your clinical database and other large-scale biomedical databases (TO) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A short talk at the European Society of Human Genetics Conference (ESHG) 2024 as part of the workshop: How to make the most of your clinical database and other large-scale biomedical databases |
| Year(s) Of Engagement Activity | 2024 |
| Description | A very friendly introduction to polygenic risk scores |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A 1.5 hour introduction talk which was a prequel to a research talk on the same topic the following evening. It was written specfically for members of the public as part of the Cambridge Festival 2023. It included a Q&A to an expert panel (colleagues from the Public Health Genomics (PHG) Foundation, a Research Genetic Counsellor and the Medical Director, Our Future Health) who could answer questions on genetic health predictions. |
| Year(s) Of Engagement Activity | 2023 |
| Description | BHF Annual Committee Members Meeting 07/11/2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Update on the year and introduction of the strategy review/refresh. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Big Biology Day (Oct 14th) - "DNA arts and crafts: Hands-on genetic risk scores" Â stall |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | DNA arts and crafts hands-on educational event for 1 day. Participants got to score your sequence for risk of heart disease.This hands-on activity involved designing a new DNA sequence with a variety of art materials. Like genetic researchers, participants compared the DNA sequence they made to known sequences to see if they could spot any future heart problems. This opened up a conversation on what life choices you can make to prevent heart disease. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.hillsroad.ac.uk/latest-news/big-biology-day-is-10-years-old |
| Description | CVRISK-IT project: national CVRISK-IT project funded by the Italian Ministry of Health- 10/06/2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Integrated approaches towards a personalized cardiovascular prevention and CVRISK-IT study Scientific Validation |
| Year(s) Of Engagement Activity | 2024 |
| Description | Cancer Data (CD3) Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Vision for Cancer Data Driven Detection, Research Data Resources Across UK, Emerging Cancer Risk Factors |
| Year(s) Of Engagement Activity | 2023 |
| Description | Chairing European Association of Preventive Cardiology webinar on 'How to treat patients with borderline dyslipidemia' Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Webinar on 'How to treat patients with borderline dyslipidemia' for the European Society of Cardiology with Q+A. This talk reached an international audience of interested clinical and professional pracititioners. Live questions from audience provided opportunity for direct communication and discussion. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DNA arts and crafts: Hands-on genetic risk scores |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We were invited to take part in the "For Your Inspiration: inside DNA" organised by the Royal Institution in partnership with The Genetics Society open to school children and their parents over 5 hours (evening). Our stall was a hands-on activity to explain how our genetics can contribute to our health risks, how that differs for different people, what we can do about the risk. We used a hands-on arts and crats activity to conceptulise what a genetic risk score is in a fun and tangible way. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.rigb.org/whats-on/your-inspiration-inside-dna |
| Description | Event at the Cambridge Festival - "Using health data to understand the causes of disease to improve health care". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A 1 hour talk with showcasing the work of two early career research written specfically for members of the public as part of the Cambridge Festival 2023. The purpose was to explain how the huge amount of health data taken from electronic health records can be anaylsed using complex statistical models can help us understand why some people are at risk of diseases, e.g. to investigate the association of COVID-19 with cardiovascular disease. Explaining clearly how genetic risk is not a straight line to clinical risk in many diseases and why that might be. Looking at the limitations of the data and what could be better. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Family & Friends day in Victor Phillip Dahdaleh Heart and Lung Research Institute- "AI and green computing" Â stall |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | An hands-on computing activity to demonstrate the power of AI to identify objects. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.hlri.cam.ac.uk/post-110/ |
| Description | Family & Friends day in Victor Phillip Dahdaleh Heart and Lung Research Institute- "DNA arts and crafts: Hands-on genetic risk scores" Â stall |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | DNA arts and crafts hands-on educational event for 1 day. Participants got to score your sequence for risk of heart disease.This hands-on activity involved designing a new DNA sequence with a variety of art materials. Like genetic researchers, participants compared the DNA sequence they made to known sequences to see if they could spot any future heart problems. This opened up a conversation on what life choices you can make to prevent heart disease. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.hlri.cam.ac.uk/post-110/ |
| Description | Festival of Tomorrow 2024 - It took place at the Deanery CE Academy, Swindon over half-term and was open to all ages |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Organised games and activities relating to statins and health: "Make Sam Well" (a cardboard cut-out of a human body with our main organs and arteries with 'bad 'cholesterol velcro-ed along the arteries. The participant had to answer questions relating to cardiovascular health correctly in order to remove the cholesterol. There were different sets of questions for different ages.), "Don't Lose Your Balls" (a team activity for adults and older children (15+) - answering questions about living a healthy life and the role of statins in staying healthy and voting for the correct answer by putting the balls in one of three buckets, balls in the wrong bucket are removed and the team with the largest number of balls at the end is the winner) and the Clinical Trials board (a self-teaching interactive board introducing the concepts of randomised controlled trials and meta-analyses and how these contribute to our knowledge of safety and efficacy of statin medication). Facilitated "DataLand" which uses Lego to explain what data are, collecting, showing and combining data. This was originally aimed at primary school children but can be used with all ages. |
| Year(s) Of Engagement Activity | 2023 |
| Description | HDR UK Seminar Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Series of seminars in Epidemiology |
| Year(s) Of Engagement Activity | 2024 |
| Description | HDR UK Strategy and Integration Group Retreat- 24/09/2024 and 25/09/2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Reflect on HDR UK's position in a complex and changing ecosystem and learn from others to gain new insights. Discuss and agree our science and infrastructure priorities to enable greater impact. |
| Year(s) Of Engagement Activity | 2024 |
| Description | HDRUK Impact of the Year Award - Selection Committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Samantha Ip served as a member of the selection committee for the HDRUK Impact of the Year Award 2024, I contributed expert judgement to assess and recognise outstanding research impact. This role involved critical evaluation of research proposals and outcomes |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.hdruk.ac.uk/hdr-uk-annual-prizes/impact-of-the-year-award/ |
| Description | Health Data Science Insights - Cambridge Podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The podcast features discussions on health data science, with guest speakers, and is aimed at students and early-career researchers in the field. It has sparked conversations on the impact of AI and data science in health. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://open.spotify.com/show/5C8UU5yoGqIPOlgULAeHTQ?si=f4cff45a2e6b4a02 |
| Description | Hot Topics in Epidemiology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5 series of hot topics seminars in Epidemiology |
| Year(s) Of Engagement Activity | 2023 |
| Description | Human Genetics Retreat |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Reviewing collaboration, innovation and leadership activities of Human Genetics Group |
| Year(s) Of Engagement Activity | 2023 |
| Description | I am a scientist chat (9 times as part of different events) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | "I'm a scientist" initiative connects researchers with school students through live chats and online Q&A sessions. This demystified research and scientific careers for the students, providing real-world insights into research and encouraging critical thinking and curiosity in STEM subjects. The impact of this is to increase public awareness of CEU research on genetics, cardiovascular health, and epidemiology, inspiring students to consider careers in statistics and public health, while also enhancing my science communication skills through real-time engagement with non-specialist audiences. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://imascientist.org.uk/ |
| Description | In-person short course: Practical statistics for epidemiology (JC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Attracted 25 students from several counties to attend this in person short course, and provided bursaries for 4 students from LMIC to attend free-of-charge |
| Year(s) Of Engagement Activity | 2024 |
| Description | La Caixa Expert Panel: Selection Committees member in Barcelona, Spain. Emanuele Di Angelantonio |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Evaluation panel of funding assessments for health research proposals, with constructive feedback to help improve the next generation of applications. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Leducq Foundation Scientific Advisory Committee Meeting- 26/10/2023 & 28/10/2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | To seek advice on future Leducq Foundation projects and consider the Letters of Intent submitted under the International Networks of Excellence Program |
| Year(s) Of Engagement Activity | 2024 |
| Description | Media engagement around the environmental impacts of computing, Loic Lannelongue |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media coverage in the Times Higher Education, Physics World and other newspapapers. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://physicsworld.com/a/researchers-issue-warning-over-the-increasing-carbon-footprint-of-computa... |
| Description | Media engagement around the environmental impacts of computing, Loic Lannelongue |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | interview with BBC radio/The Naked Scientists in January 2023 and June 2023 (recorded and broadcasted live and also released as a podcast). Media coverage in the Times Higher Education, Physics World and other newspapapers. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.thenakedscientists.com/articles/interviews/calculating-computers-carbon-footprint |
| Description | New Scientist interview - Sam Ip |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | New Scientist interviewed Samantha Ip for an expert commentary on the long-term cardiovascular safety of COVID-19 vaccines based on her NCOMM paper on COVID-19 vaccines safety, in particular their associations with CVD. The discussion aimed to clarify scientific findings for a broad audience, increasing public understanding and addressing prevalent concerns about vaccine safety. |
| Year(s) Of Engagement Activity | 2024 |
| Description | New risk calculator can help prevent heart attacks and strokes in people with type 2 diabetes |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | To publicise the availability of the updated new health risk calculator SCORE2 an help prevent heart attacks and strokes in people with type 2 diabetes |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2023/november/risk-calculator-preve... |
| Description | Novartis CVM Council Advisory Board |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | To seek advice on future Novartis projects and trends in cardiovascular and metabolic diseases. To discuss strategic issues that are relevant to Novartis and to maximize the experts' input and advice into the areas of heart failure, atherosclerosis, inflammation, arrhythmia, and dyslipidemia. Presentation - Pelacarsen primary prevention |
| Year(s) Of Engagement Activity | 2023 |
| Description | Novartis CVM Council Advisory Board |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | To seek advice on future Novartis projects and trends in cardiovascular and metabolic diseases. To discuss strategic issues that are relevant to Novartis and to maximize the experts' input and advice into the areas of heart failure, atherosclerosis, inflammation, arrhythmia, and dyslipidemia. Presentation - Targeting APOC3 and ANGPTL3: an update |
| Year(s) Of Engagement Activity | 2024 |
| Description | Online Comedy Panel :Â NEVER EXPLAIN online science comedy charity panel show |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Entertaining and informative show where I showcased current research ideas and methods in a humorous fashion, to make them more accessible and appealing to a general audience. A good way to test new altlernative formats to engage with the public on our reearch |
| Year(s) Of Engagement Activity | 2023 |
| Description | Online short course "Introduction to Epidemiology" (JC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Attracted 25 students from several counties to attend this online short course, and provided bursaries for five students from LMIC to attend free-of-charge. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ndph.ox.ac.uk/study-with-us/introduction-to-epidemiology |
| Description | Organised STRIDES celebration event Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Following the STRIDES study's huge success, a Celebration Event was hosted at Clare College, Cambridge. Presented on 'STRIDES Study design and rationale'. Representatives from UCAM, NHSBT, NIHR, NIHCR as well as lay representatives from the management committees (PPIE) came together to reflect on the hard work and achievement of this huge collaborative effort. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Our Future Health Access Board Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | To discover and test more effective ways to predict, detect and treat major diseases through a dataset that truly reflects the UK's population. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Our Future Health Access Board Meetings |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | To discover and test more effective ways to predict, detect and treat major diseases through a dataset that truly reflects the UK's population |
| Year(s) Of Engagement Activity | 2024 |
| Description | OxPop Festival of Global Health (SL) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Festival of Global Health was launched in Autumn 2023 and has hosted six events covering a wide range of topics relevant to global health. At each event, we screened a film followed by a panel discussion including film makers and academic experts and finish with a social event. Over 500 people have attended the events in total. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Oxford BHF CRE Symposium 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Showcase of cardiovascular research tools and facilities, bridging Oxford's cardiovascular and dementia research |
| Year(s) Of Engagement Activity | 2023 |
| Description | PPIE showcase talk 25/06/2024 Amy Mason |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Amy presented Genetic Destinies - involving patients and the public in complex conversations about genetic risk using theatre at the Cambridge PPI Showcase, organised by the NIHR Biomedical Research Centre (BRC). The purpose of my talk was to showcase how theatre and interactive storytelling can help patients and the public engage with the complexities of genetic risk, probability, and inheritance, making abstract scientific concepts more accessible and personally relevant. Her talk was voted Best Afternoon Presentation by the audience, demonstrating its effectiveness in engaging attendees. The impact of this event was Researchers and PPI contributors gained insights into using creative approaches to communicate genetics and encourage dialogue about personal risk perception. |
| Year(s) Of Engagement Activity | 2024 |
| Description | PPIE workshops and report titled "Equitable, trustworthy, and safe research in healthcare technology, data and artificial intelligence: an international dialogue". |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Our researcher with colleagues from Cambridge Public Health and the International Health Systems group at the Engineering Design Centr conducted two workshops, one in Uganda and one in the UK. The aim was to develop an in-depth understanding of attitudes to research involving the use of healthcare data, technology, and artificial intelligence. Our researcher was involved in the Cambridge workshop. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://zenodo.org/records/14503478 |
| Description | Policy Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In May 2023, the BELIEVE study group organised and hosted a hybrid policy seminar event, which was based physically in Bangladesh with remote connection for Cambridge colleagues. The National Heart Foundation of Bangladesh, our collaboration partner in the urban setting, took the lead role in the organisation and hosting the event, with content support from Cambridge colleagues. The policy seminar agenda created a forum to disseminate primary findings from the cohort research thus far and to share an overview of the CAPABLE-related capacity building programmes which have been held in Bangladesh to date. In doing so, the purpose, value and impact of the CAPABLE research programme was highlighted to the audience. CAPABLE's Principal Investigators and senior scientists based in both Cambridge and Bangladesh gave presentations throughout the event. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Polygenic Risk Scores in research and healthcare |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A 1 hour talk with showcasing the work of two early career research written specfically for members of the public as part of the Cambridge Festival 2023. 1) Research around iron regulation and iron disorders, using Polygenic Risk Scores to understand the consequences of iron on disease 2) research in assessing and improving fairness in medical prediction algorithms, including in Polygenic Risk Scores, and building machine learning algorithms for fair medical risk prediction. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.youtube.com/@cambridgeunicardiovascular9654 |
| Description | Poster judge for the Cambridge Cardiovascular BHF CRE Annual Research Symposium, Cambridge UK Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | As a poster judge on the theme of Functional Genomics for the Cambridge Cardiovascular BHF CRE Annual Research Symposium, current active research was reveiwed and topics of special interest were highlighted to research audiences as being relevant and important. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster making workshop 12/02/2024 Amy Mason |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Amy organised and led a hybrid poster-making presentation and planning session, aimed at supporting researchers and students in developing effective scientific posters for conferences and public engagement events. The session covered key aspects of poster design, layout, and communication strategies, ensuring that complex research findings are presented in a clear, visually engaging, and accessible way. Outcomes included: Improved poster design skills, with participants applying key principles of effective visual communication and ensuring research posters are accessible to both scientific and lay audiences. Attendees left the session with a clear plan for their own posters and a better understanding of what makes a research poster impactful. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presenting at ESC Preventive Cardiology 2023 in Malaga, Spain Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting at ESC Preventive Cardiology 2023 on 'Cardiovascular risk in type 2 diabetes mellitus: how to assess and how to manage' and 'How genes and the environment interact to shape individual CV risk' |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presenting the BELIEVE cohort profile at Richard Doll Symposium, Oxford UK Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenting on Cohort profile: BangladEsh Longitudinal Investigation of EmergingVascular Events (BELIEVE) study. The Richard Doll Consortium facilitates collaboration between researchers and promotes data sharing to produce reliable estimates of the major causes of premature death with which to inform public health policies. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Public roundtable event: How does Mendelian randomization help us make sense of diseases? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Mendelian randomization is a powerful tool used in health research to investigate causes of diseases and disorders using information about people's genetics. On 20th June, world-leading experts in this topic discussed the latest advances in the field and we are inviting you to join us. Our in-person roundtable event will see these experts sit down with members of the public to discuss the latest research in genetics and its impact on health outcomes. Experts discussed what we mean by terms like causal inference and epidemiology and what they look like in practice. Explored why looking at diverse populations is important for understanding diseases better and how we determine which findings are trustworthy. Looked at what these approaches mean for our mental and physical health and how we can identify drug targets. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.mendelianrandomization.org.uk/roundtable/ |
| Description | Round table discussion and poster presentation at AHA Scientific Sessions (Chicago; JC) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Guiding a table of about a dozen conference attendees about publicly available large-scale datasets for cardiovascular research and presenting a poster of research on the analysis of body composition using DXA in the Malaysian Cohort and UK Biobank. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Sanger Scientific Symposium 2024 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | To promote/increase cross programme science collaborations |
| Year(s) Of Engagement Activity | 2024 |
| Description | Short course in 'Practical Design of Epidemiological Studies' (JC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The PRADES course played a transformative role in advancing research capacity in Africa by equipping twenty early-career researchers with essential skills in study design, grant writing, and data analysis. Following these courses, two participants submitted 5 manuscripts within a year. One participant submitted a Fellowship application. One of the study designs developed during this course was submitted for funding with an interdisciplinary international team. The PRADES course also led to a visiting fellowship of one attendee to Oxford, and the development of the collaboration of AMEDRA and the development of ASANDE data with Dr Carter. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Short presentation at Technology meeting in Manchester (Sam Lambert) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Meeting was held in Manchester, 14th of November 2023. It was a highly technical meeting to discuss data flows/tech stacks/software solutions. Sam Lambert gave a quick presentation on technical details (challenges/software/solutions) associated with Molecules to Health Records project. Expected outcomes - to provide with an oversite of what each project is doing and identify how they could all work together on some components/ use each other's software. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Short talk at HDR UK Oxford Region Meeting (JC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Short talk at HDR UK Oxford Region Meeting: Investigation classic risk factors in diverse populations: lessons from The Malaysian Cohort |
| Year(s) Of Engagement Activity | 2024 |
| Description | Speak at annual BTRU GEMS meeting in Birmingham, UK Emanuele Di Angelantonio |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Presented 'Human genetics in donor research' at the BTRU Genomics to Enhance Microbiology Screening (GEMS) First Annual Meeting. The meeting was attended by researchers from University of Oxford and UCL, from NHSBT and other blood services and by members of the UK Health Security Agency (formerly PHE) involved in the programme. The BTRU-GEMS Programme. This NIHR-funded programme brings together researchers, clinicians and those working for blood and public health services from the University of Oxford, University College London, NHS Blood and Transplant and UK Health Security Agency. The overarching aim of the BTRU is to evaluate the role of genomics-based technologies to reduce the transmission risk of infectious agents in blood and transplant." |
| Year(s) Of Engagement Activity | 2023 |
| Description | Speaker at Seminar on CAPABLE Program, with National Heart Foundation of Bangladesh Emanuele Di Angelantonio |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Special guest speaker at National Heart Foundation of Bangladesh seminar titled 'From Science to Policy: Advancing NCD Research with the CAPABLE Program Policy Seminar'. The prupose of this seminar was to disseminate primary findings from the cohort research and capacity building programs among the community leaders. Scientists and Eminent experts from Bangladesh and University of Cambridge presented up to date information and exchange views on NCDs research findings. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk at the HDRUK Leadership and Strategy Retreat (Sam Lambert) "Polygenic Score Catalogue" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The event brought together over 70 individuals across the HDR UK network. Event aim was to network, discuss strategic priorities and give spotlight to Early Carrier researchers. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk at the HDRUK Leadership and Strategy Retreat on "COVID-19, Cardiovascular Events, and Cancer Risk Prediction." (Sam Ip) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The event brought together over 70 individuals across the HDR UK network. Event aim was to network, discuss strategic priorities and give spotlight to Early Carrier researchers. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk: China Kadoorie Biobank at Establishing Biobanks in Longitudinal Cohorts Symposium, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC), Varanasi, India. (FB) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk at Establishing Biobanks in Longitudinal Cohorts Symposium, Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC), Varanasi, India. The talk described China Kadoorie Biobank. |
| Year(s) Of Engagement Activity | 2024 |
| Description | The Big Funding Panel, Thursday 30th March, 6.30-8pm, HLRI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Researchers pitched imaginary projects to members of the public who voted on them. The aim was to demonstrate how public and charitable funding is allocated to research projects |
| Year(s) Of Engagement Activity | 2023 |
| Description | The Naked Scientists Podcast, Sam Ip |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In this podcast interview (broadcast on BBC Radio on 02 August 2024), Samantha Ip discussed her NCOMM paper on COVID-19 vaccines safety, in particular their associations with CVD. The discussion aimed to clarify scientific findings for a broad audience, increasing public understanding and addressing prevalent concerns about vaccine safety. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Type 2 diabetes diagnosis at age 30 can reduce life expectancy by up to 14 years |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | To publicise an important study that highlghts the health risks of having Typehighlight the urgent need to develop and implement interventions that prevent or delay onset of diabetes, especially as the prevalence of diabetes among younger adults is rising globally. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cam.ac.uk/research/news/type-2-diabetes-diagnosis-at-age-30-can-reduce-life-expectancy-b... |
| Description | UK Biobank International Scientific Advisory Board |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FOR JOHN |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Strategic Oversight Committee Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FOR JOHN |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK Biobank Strategic Oversight Committee Meeting - 29/05/2024 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Accessibility of platform for all new applications |
| Year(s) Of Engagement Activity | 2024 |
| Description | UK wide "I'm a Scientist" online forum chats with young people with schools all over the UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | I'm a Scientist is online, pseudonymous, and informal. These characteristics encourage students to ask personally relevant questions and have direct access to researchers. The format promotes: Science literacy, Seeing science as relevant to everyday life, Knowledge about the transferability of science (3), and especially Knowing people in science-related jobs. Our researcher took part in 15 chats in 2024 with schools all over the UK, and ranged in age from 5 years olds to 19 year olds. |
| Year(s) Of Engagement Activity | 2024 |
| Description | University of Cambridge Festival: DNA and health - arts and crafts |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | An experiential science education activity - a talk and craft activity. Amy Mason lead the session which used beads and elastic to make bracelet models of DNA, the children will then use those models to learn how to detect bad characteristics like risk of disease and what scientists are doing at the University of Cambridge to understand and prevent diseases such as heart disease. This session was with Key Stage 2 children (age 7-11, primary school). This was part of 'Schools day' where teachers brought their classes rather than expecting parents and carers to know about the Cambridge festival. |
| Year(s) Of Engagement Activity | 2024 |
| Description | University of Cambridge Festival: Artificial Intelligence: With great power comes great responsibility |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk written and presented by an active researcher in AI. The researcher explained the background and then gave real life examples of the merits and downsides of AI. The session had an open audience Q&A which was popular |
| Year(s) Of Engagement Activity | 2024 |
| Description | University of Cambridge Festival: Teddy bears' clinic at the Royal Papworth Hospital Clinical Research Facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An experiential science education activity to learn all about clinical research. Teddy bears' clinic at the Royal Papworth Hospital Clinical Research Facility guided children and their parents. The objectives were Sharing personal electronic health records. Children Children will become familiar with the concept of giving consent to share their Teddy Bear's electronic health records for research purposes. Clinical trial enrollment. Children will learn about enrolling their teddy bear in a clinical trial, including the concepts of giving consent and understanding randomization. Role-Play with the Teddy Bear in the Clinic. This activity will help children become familiar with a hospital setting and healthcare staff, supporting them in making informed decisions for their teddy bear. Approximately 80-90 children participated. Around two-thirds of the children brought teddy bears. 40 of the teddy bears consented to participate in the clinical trial. Regarding the registration for the clinical trial, all children to whom it was proposed agreed to participate. When children wanted to change their assigned group, we explained to them that randomization could not be changed and why it is important. As an overall outcome, we believe that children over 6/7 were sensitized to the concept of a clinical trial and understood how it works, why consent is necessary for using data in clinical trials, and for medical procedures. For younger children, we think they did not fully grasp the differences among these concepts of consent, but they did understand the overall concept of consent and signed it. |
| Year(s) Of Engagement Activity | 2023,2024 |
| Description | University of Cambridge Festival: Who has the healthiest heart?" |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An experiential science education activity to learn all about cardiovascular disease risk prediction and how it can identify adults at risk of heart diseases. Participants were able to determine which the characters have the healthiest heart according to their medical charts. This stimulated a lot of conversations with the public about health risks and preventing them. The healthy hearts card game really brong the it to life; appreciate seeing the data of the Q3 risk scores One woman age 44 did a health check with GP and was told that she has high cholesterol which worried her initially but her doctor told her that everything else is ok so she didn't need statins. She was reassured playing the game and seeing how different risk factors come into play and that how high cholesterol is only part of the picture. We reached a broad audience including a local Ukrainian refugee community. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Work Experience (LH) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Work experience afternoon for three further education students. There was a presentation about our research followed by some hands on practice of data analysis. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Workshop: Sanger Institute Human Genetics Programme and University Cardiovascular Epidemiology Unit -09/01/2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Fostering collaboration, innovation and leadership activities between Sanger/CEU/HDR-UK PIs |
| Year(s) Of Engagement Activity | 2024 |