A National Centre for Protein Kinase Profiling
Lead Research Organisation:
University of Dundee
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
Publications
Caster DJ
(2013)
ABIN1 dysfunction as a genetic basis for lupus nephritis.
in Journal of the American Society of Nephrology : JASN
Clark K
(2013)
Molecular control of the NEMO family of ubiquitin-binding proteins.
in Nature reviews. Molecular cell biology
Cohen P
(2013)
Kinase drug discovery--what's next in the field?
in ACS chemical biology
Cohen P
(2014)
Immune diseases caused by mutations in kinases and components of the ubiquitin system.
in Nature immunology
Cohen P
(2014)
The TLR and IL-1 signalling network at a glance.
in Journal of cell science
Emmerich C
(2013)
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
in Proceedings of the National Academy of Sciences
Kelsall I
(2022)
HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation
in The EMBO Journal
Krishnan N
(2013)
The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases.
in The FEBS journal
Lin KM
(2014)
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.
in Proceedings of the National Academy of Sciences of the United States of America
Ordureau A
(2013)
DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.
in The Journal of biological chemistry
| Description | 8th World Conference on Waldenstrom's Lymphoma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | On the evening of August 16th Philip Cohen gave the closing lecture of the 8th International Workshop on Waldenstrom's Lymphoma in the Churchill rooms of the Houses of Parliament in London. Waldenstrom's lymphoma is caused by mutations in the protein MyD88, and 95% of the patients who are afflicted by this disease express the same mutant in which the leucine residue at position 265 is changed to proline. MyD88 is an essential adaptor protein in the signalling networks that are triggered by the binding of bacterial and viral components to Toll-Like Receptors or by the interaction of interleukins 1, 18 and 33 with their receptors. Philip's talk to an audience that mainly comprised patients with Waldenstrom's lymphoma, their physicians, relatives and friends, focused on how MyD88 was discovered, and its key role in the innate immune system that is vital for protection against infection by microbial pathogens, especially during childhood. He also explained how the hyper-activation of the MyD88-dependent signalling network can lead to autoimmune diseases, such as lupus, and how its constitutive activation caused by the MyD88[Leu265Pro] mutation leads to lymphoma. The talk was followed by a formal dinner in the Churchill rooms, at which Philip and Tricia Cohen were the guests of honour. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Interview with ZDF (German National Public Broadcasting) Regarding Scottish Referendum |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | ZDF wished to interview Professor Cohen regarding the risks for life sciences in an independent Scotland for their European affairs programme that wished to discuss an economic case for and against independence. Sir Philip's signature on an open letter and viewpoints expressed, while his own, brought to light in the general public, the potential deleterious impact a 'Yes' vote would have had upon Scottish scientific research funding. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.zdf.de/ZDFmediathek#/hauptnavigation/startseite |
| Description | New Drugs for the 21st Century |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | "Philip Cohen gave a talk about kinase drug discovery to the Scotland International Group at the Gleneagles Hotel Scotland on Friday November 29th 2013. Entitled "New Drugs for the 21st Century". The audience of 60 included the CEOs and CFOs of 20% of the UK's FTSE 100 companies, the Brazilian and Russian Ambassadors, the former UK Ambassador to the USA, the former Secretary General of NATO), Sir the former head of UK Government Operations, and Scotland's only two billionaires." Sir Philip's talk stimulated much discussion as he recounted the research being undertaken in Dundee and the potential of many of the targets torwards therapeutic development. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Scotland: For Richer or Poorer? |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Sir Philip Cohen will be featured on Robert Peston's BBC2 Documentary 'Scotland: For Richer or Poorer' airing tonight at 9pm on BBC2. How will independence affect Dundee's reputation for excellence in life sciences? Sir Philip's signature on an open letter and viewpoints expressed, while his own, brought to light in the general public, the potential deleterious impact a 'Yes' vote would have had upon Scottish scientific research funding. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.bbc.co.uk/iplayer/episode/b049b89z/scotland-for-richer-or-poorer |
| Description | Scottish Referendum - Open Letter |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | "A group of eminent Scottish medical experts have warned that independence would seriously damage research funding for Scotland's universities and medical schools. The open letter from 14 experts, including senior staff from all five of the country's main medical schools, said they had ""grave concerns"" that Scotland's world-leading biomedical and life sciences research would suffer if Scotland ""sleepwalks"" into leaving the UK. The letter, coordinated by Sir David Carter, a former chief medical officer in Scotland, said Scottish universities did disproportionately well out of the UK's research funding system and from the UK's charitable and medical foundation grants. " Sir Philip's signature on an open letter and viewpoints expressed, while his own, brought to light in the general public, the potential deleterious impact a 'Yes' vote would have had upon Scottish scientific research funding. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.theguardian.com/politics/2014/may/23/scottish-independence-research-funding-medical-exper... |
| Description | Student's important protein discovery could help fight cancer |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Jiazhen Zhang, a research student in Professor Sir Philip Cohen's laboratory at the University of Dundee, has uncovered how the protein complex, called NF-?B, is activated. The results are published in July, 2014. Research being undertaken in the Cohen lab was discussed by the broader lay community in an effort to share the impact of these studies |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://news.stv.tv/tayside/282195-jiazhen-zhang-at-university-of-dundee-publishes-research-on-nf-b/ |