Establishment of a Core Translational Imaging Facility for Animal Models of Infection at Nottingham University
Lead Research Organisation:
University of Nottingham
Department Name: UNLISTED
Abstract
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Technical Summary
Nottingham University were awarded £824K to establish a Core Translational Imaging Facility for Animal Models of Infection. This is a key area of strategic priority. Infections caused by multi-resistant bacteria pose an enormous worldwide healthcare challenge which is being compounded by the lack of new antibacterial agents, the closure of antibacterial drug discovery programmes in the pharmaceutical industry and the drift of academic expertise away from bacteriology. Thus the need for new antibacterial strategies is escalating and there is an urgent need to identify novel antibacterial targets if new compounds capable of controlling bacterial pathogens are to be discovered. It is therefore essential that we gain in-depth insights into the molecular and cellular lifestyles of bacterial pathogens both in vitro and in vivo. Given the scale of the clinical problem, it is imperative that critical mass is achieved and sustained in this research field and has sufficient capacity to respond to these challenges through basic and translational research and research training programmes. In this context, Nottingham has unique strengths through the co-location of the internationally recognized molecular, cellular and clinical bacteriology research groups of the Institute of Infection, Immunity and Inflammation (III) in the new £25 million Centre for Biomolecular Sciences (CBS) and via the affiliated Animal Infection Group at the recently established School of Veterinary Medicine and Science. The infection groups are also closely associated with the recently NIHR-funded Biomedical Research Units in Gastroenterology and Respiratory Medicine which constitute an £8.9 million investment.
Organisations
Publications
Lau FH
(2018)
Sandwiched White Adipose Tissue: A Microphysiological System of Primary Human Adipose Tissue.
in Tissue engineering. Part C, Methods
Lewis JE
(2017)
Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster.
in Scientific reports
John AE
(2013)
Preclinical SPECT/CT imaging of avß6 integrins for molecular stratification of idiopathic pulmonary fibrosis.
in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
He Y
(2022)
Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices.
in Biomaterials
Singh T
(2020)
Discovery of hemocompatible bacterial biofilm-resistant copolymers.
in Biomaterials
Hook AL
(2012)
Combinatorial discovery of polymers resistant to bacterial attachment.
in Nature biotechnology
Lewis JE
(2017)
Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice.
in Endocrinology
Samms RJ
(2015)
Antibody-Mediated Inhibition of the FGFR1c Isoform Induces a Catabolic Lean State in Siberian Hamsters.
in Current biology : CB
Mills B
(2015)
[(18)F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections.
in EJNMMI research
Awais R
(2014)
99mTc-labelling of surface localised SNAP-tag sites on a Gram positive bacterium
in Nuclear Medicine and Biology
Description | Imaging Equipment and Refurbishment Grant |
Amount | £2,860,000 (GBP) |
Organisation | University of Nottingham |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2009 |
End | 03/2011 |
Description | Platform Technology Fund |
Amount | £127,929 (GBP) |
Organisation | University of Nottingham |
Sector | Academic/University |
Country | United Kingdom |
Start | 08/2011 |
End | 07/2014 |